Patents by Inventor Florence M. Hofman
Florence M. Hofman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10561663Abstract: A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.Type: GrantFiled: August 22, 2018Date of Patent: February 18, 2020Assignee: University of Southern CaliforniaInventors: Jean C. Shih, Florence M. Hofman, Thomas C. Chen
-
Publication number: 20190367918Abstract: The invention relates to compositions, methods and kits for using Argonaute-2 (Ago-2) as a systemic carrier to deliver a miRNA to an endothelial cell. The invention also relates to compositions, methods and kits for inhibiting angiogenesis and/or treating a condition by using Ago-2 as a systemic carrier to deliver a miRNA to an endothelial cell. The condition includes but is not limited to brain vascular diseases and brain tumors.Type: ApplicationFiled: June 5, 2019Publication date: December 5, 2019Inventors: Florence M. Hofman, Raquel M.S. Ferreira, Steven L. Giannotta, Thomas C. Chen
-
Publication number: 20190048346Abstract: The invention relates to compositions, methods and kits for using Argonaute-2 (Ago-2) as a systemic carrier to deliver a miRNA to an endothelial cell. The invention also relates to compositions, methods and kits for inhibiting angiogenesis and/or treating a condition by using Ago-2 as a systemic carrier to deliver a miRNA to an endothelial cell. The condition includes but is not limited to brain vascular diseases and brain tumors.Type: ApplicationFiled: October 24, 2018Publication date: February 14, 2019Inventors: Florence M. Hofman, Raquel M.S. Ferreira, Steven L. Giannotta, Thomas C. Chen
-
Patent number: 9675620Abstract: A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.Type: GrantFiled: February 5, 2015Date of Patent: June 13, 2017Assignee: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Jean C. Shih, Florence M. Hofman, Thomas C. Chen
-
Publication number: 20170065691Abstract: The invention describes immunotherapies for treating various cancers in nervous system, particularly brain cancer. In various embodiments, the method may comprise: obtaining a tumor tissue from the subject; preparing a tumor cell lysate from the tumor tissue; isolating an immune cell from the subject; priming the immune cell against the tumor cell lysate. In various embodiments, intraventricular delivery of dendritic cells for brain cancer immunotherapy is disclosed.Type: ApplicationFiled: March 18, 2015Publication date: March 9, 2017Applicant: University of Southern CaliforniaInventors: Thomas C. Chen, Florence M. Hofman
-
Publication number: 20160369272Abstract: The invention relates to compositions, methods and kits for using Argonaute-2 (Ago-2) as a systemic carrier to deliver a miRNA to an endothelial cell. The invention also relates to compositions, methods and kits for inhibiting angiogenesis and/or treating a condition by using Ago-2 as a systemic carrier to deliver a miRNA to an endothelial cell. The condition includes but is not limited to brain vascular diseases and brain tumors.Type: ApplicationFiled: March 11, 2015Publication date: December 22, 2016Applicant: University of Southern CaliforniaInventors: Florence M. HOFMAN, Raquel M.S. FERREIRA, Steven L. GIANNOTTA, Thomas C. CHEN
-
Publication number: 20160367672Abstract: The invention relates methods and systems of using a nanoparticle and near infrared radiation to treat, prevent, reduce the likelihood of having, reduce the severity of and/or slow the progression of a condition in a subject. The invention also relates to compositions comprising a nanoparticle. Conditions treatable with the methods systems and compositions include but are not limited to various tumors.Type: ApplicationFiled: March 3, 2015Publication date: December 22, 2016Applicant: University of Southern CaliforniaInventors: Thomas C. CHEN, Florence M. HOFMAN, Tiago A.R.T.S. SANTOS
-
Publication number: 20160339034Abstract: A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.Type: ApplicationFiled: February 5, 2015Publication date: November 24, 2016Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Jean C. Shih, Florence M. Hofman, Thomas C. Chen
-
Patent number: 9486461Abstract: The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.Type: GrantFiled: February 4, 2015Date of Patent: November 8, 2016Assignee: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Nicos A. Petasis, Florence M. Hofman, Stan G. Louie, Thomas C. Chen, Axel H. Schonthal
-
Publication number: 20160008378Abstract: The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.Type: ApplicationFiled: February 4, 2015Publication date: January 14, 2016Inventors: Nicos A. PETASIS, Florence M. Hofman, Stan G. Louie, Thomas C. Chen, Axel H. Schonthal
-
Publication number: 20150209361Abstract: A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.Type: ApplicationFiled: February 5, 2015Publication date: July 30, 2015Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Jean C. Shih, Florence M. Hofman, Thomas C. Chen
-
Publication number: 20140295549Abstract: The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.Type: ApplicationFiled: December 17, 2013Publication date: October 2, 2014Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Nicos A. PETASIS, Florence M. HOFMAN, Stan G. LOUIE, Thomas C. CHEN, Axel H. SCHONTHAL
-
Publication number: 20140288115Abstract: It is discovered that noscapine is effective in treating temozolomide (TMZ)-resistant brain cancer. Provided are compositions and methods of treating brain cancer patients, in particular those that are TMZ-resistant. The patients are treated by administration of a therapeutically effective amount of noscapine or an analog thereof. In certain aspects, TMZ is also administered to the patients. Examples of brain cancers include glioma such as glioblastoma multiforme.Type: ApplicationFiled: June 6, 2014Publication date: September 25, 2014Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Thomas C. Chen, Florence M. Hofman, Stan G. Louie, Axel H. Schonthal, Nicos A. Petasis
-
Patent number: 8637564Abstract: The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.Type: GrantFiled: June 14, 2011Date of Patent: January 28, 2014Assignee: University of Southern CaliforniaInventors: Nicos A. Petasis, Florence M. Hofman, Stan G. Louie, Thonas C. Chen, Axel H. Schonthal
-
Publication number: 20110318837Abstract: The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.Type: ApplicationFiled: June 14, 2011Publication date: December 29, 2011Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Axel H. SCHONTHAL, Nicos A. PETASIS, Florence M. HOFMAN, Stan G. LOUIE, Thonas C. CHEN
-
Patent number: 7981917Abstract: The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.Type: GrantFiled: March 26, 2008Date of Patent: July 19, 2011Assignee: University of Southern CaliforniaInventors: Axel H. Schönthal, Nicos A. Petasis, Florence M. Hofman, Stan G. Louie, Thomas C. Chen
-
Publication number: 20090062227Abstract: The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.Type: ApplicationFiled: March 26, 2008Publication date: March 5, 2009Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: AXEL H. SCHONTHAL, NICOS A. PETASIS, FLORENCE M. HOFMAN, STAN G. LOUIE, THOMAS C. CHEN