Abstract: A method for analyzing tissue classes along a tubular structure defined by voxels is disclosed. A tubular shaped region of interest (ROI) is constructed along a predetermined centerline of the tubular structure according to the following: at least one point is defined along the centerline to define the extremities of the ROI; a diameter corresponding to the ROI is defined and/or computed; contiguous unit volumes are applied along the centerline between the extremities of the ROI; a first volume is computed by the union of the unit volumes; and, a final volume of the ROI is defined as the connex part of the first volume that contains the middle of the tubular structure. The final volume is then analyzed with respect to tissue classes present therein.