Patents by Inventor Florencia Lim

Florencia Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10456124
    Abstract: A sealant for sealing a puncture through tissue includes a first section, e.g., formed from freeze-dried hydrogel, and a second section extending from the distal end. The second section may be formed from PEG-precursors including PEG-ester and PEG-amine, e.g., in an equivalent ratio of active group sites of PEG-ester/PEG-amine greater than one-to-one, e.g., such that excess esters may provide faster activation upon contact with physiological fluids and enhance adhesion of the sealant within a puncture. At least some of the precursors remain in an unreactive state until exposed to an aqueous physiological environment, e.g., within a puncture, whereupon the precursors undergo in-situ cross-linking to provide adhesion to tissue adjacent the puncture. For example, the PEG-amine precursors may include the free amine form and the salt form. The free amine form at least partially cross-links with the PEG-ester and the salt form remains in the unreactive state in the sealant before introduction into the puncture.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: October 29, 2019
    Assignee: ACCESS CLOSURE, INC.
    Inventors: Andreas Mylonakis, Jacky Au-Yeung, Florencia Lim
  • Publication number: 20190029659
    Abstract: A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
    Type: Application
    Filed: August 6, 2018
    Publication date: January 31, 2019
    Applicant: ACCESS CLOSURE, INC.
    Inventors: Andy H. Uchida, Anthony P. Spizuoco, Kevin To, Florencia Lim, Scott R. Sershen
  • Patent number: 10182800
    Abstract: A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: January 22, 2019
    Assignee: ACCESS CLOSURE, INC.
    Inventors: Andy H. Uchida, Anthony P. Spizuoco, Kevin To, Florencia Lim, Scott R. Sershen
  • Publication number: 20180168563
    Abstract: A sealant is provided for sealing a puncture through tissue that comprises an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The first section comprises chitosan and at least one additional polymer. The second section may be formed from a solid mass of non-freeze-dried, non-cross-linked hydrogel precursors. The precursors are in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. The second section may further comprise chitosan. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
    Type: Application
    Filed: November 21, 2017
    Publication date: June 21, 2018
    Applicant: ACCESS CLOSURE, INC.
    Inventors: ANDREAS MYLONAKIS, FLORENCIA LIM
  • Publication number: 20180168562
    Abstract: A sealant is provided for sealing a puncture through tissue that comprises an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The first section comprises chitosan and at least one additional polymer. The second section may be formed from a solid mass of non-freeze-dried, non-cross-linked hydrogel precursors. The precursors are in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. The second section may further comprise chitosan. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
    Type: Application
    Filed: November 21, 2017
    Publication date: June 21, 2018
    Applicant: ACCESS CLOSURE, INC.
    Inventors: ANDREAS MYLONAKIS, FLORENCIA LIM
  • Publication number: 20180028166
    Abstract: A sealant for sealing a puncture through tissue includes a first section, e.g., formed from freeze-dried hydrogel, and a second section extending from the distal end. The second section may be formed from PEG-precursors including PEG-ester and PEG-amine, e.g., in an equivalent ratio of active group sites of PEG-ester/PEG-amine greater than one-to-one, e.g., such that excess esters may provide faster activation upon contact with physiological fluids and enhance adhesion of the sealant within a puncture. At least some of the precursors remain in an unreactive state until exposed to an aqueous physiological environment, e.g., within a puncture, whereupon the precursors undergo in-situ cross-linking to provide adhesion to tissue adjacent the puncture. For example, the PEG-amine precursors may include the free amine form and the salt form. The free amine form at least partially cross-links with the PEG-ester and the salt form remains in the unreactive state in the sealant before introduction into the puncture.
    Type: Application
    Filed: October 6, 2017
    Publication date: February 1, 2018
    Applicant: ACCESS CLOSURE, INC.
    Inventors: Andreas Mylonakis, Jacky Au-Yeung, Florencia Lim
  • Patent number: 9861348
    Abstract: A sealant is provided for sealing a puncture through tissue that comprises an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The first section comprises chitosan and at least one additional polymer. The second section may be formed from a solid mass of non-freeze-dried, non-cross-linked hydrogel precursors. The precursors are in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. The second section may further comprise chitosan. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: January 9, 2018
    Assignee: ACCESS CLOSURE, INC.
    Inventors: Andreas Mylonakis, Florencia Lim
  • Patent number: 9833342
    Abstract: Devices and methods for treating a diseased tracheobronchial region in a mammal. The device can be a stent which can include a sustained-release material such as a polymer matrix with a treatment agent. The stent can be bioabsorbable and a treatment agent can be incorporated therewith. A treatment method can be delivery of a stent to a tracheobronchial region by a delivery device such as a catheter assembly.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: December 5, 2017
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Florencia Lim, Mary Suh, Barbara Stamberg, Bin Huang
  • Patent number: 9820728
    Abstract: A sealant for sealing a puncture through tissue includes a first section, e.g., formed from freeze-dried hydrogel, and a second section extending from the distal end. The second section may be formed from PEG-precursors including PEG-ester and PEG-amine, e.g., in an equivalent ratio of active group sites of PEG-ester/PEG-amine greater than one-to-one, e.g., such that excess esters may provide faster activation upon contact with physiological fluids and enhance adhesion of the sealant within a puncture. At least some of the precursors remain in an unreactive state until exposed to an aqueous physiological environment, e.g., within a puncture, whereupon the precursors undergo in-situ cross-linking to provide adhesion to tissue adjacent the puncture. For example, the PEG-amine precursors may include the free amine form and the salt form. The free amine form at least partially cross-links with the PEG-ester and the salt form remains in the unreactive state in the sealant before introduction into the puncture.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: November 21, 2017
    Assignee: Access Closure, Inc.
    Inventors: Andreas Mylonakis, Jacky Au-Yeung, Florencia Lim
  • Patent number: 9814553
    Abstract: The present invention provides a semi-crystalline polymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: November 14, 2017
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Lothar Walter Kleiner, Yiwen Tang, Syed Faiyaz Ahmed Hossainy, Florencia Lim, Michael Ngo, Mikael Trollsas, Qing Lin
  • Publication number: 20170189586
    Abstract: This invention is generally related to coating for implantable medical devices, such as drug delivery vascular stents, and methods of fabricating coated implantable medical devices.
    Type: Application
    Filed: March 21, 2017
    Publication date: July 6, 2017
    Inventors: Michael H. NGO, Syed Faiyaz Ahmed HOSSAINY, Florencia LIM, O. Mikael TROLLSAS
  • Patent number: 9592323
    Abstract: The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: March 14, 2017
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Florencia Lim, Mikael O. Trollsas, Syed F.A. Hossainy, Stephen D. Pacetti
  • Patent number: 9504772
    Abstract: The present invention provides an implantable article comprising an amorphous terpolymer and a semi-crystalline polymer. The amorphous terpolymer can be admixed with the semi-crystalline polymer or form a block copolymer with the semi-crystalline polymer.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: November 29, 2016
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Mikael Trollsas, Michael Ngo, Florencia Lim
  • Patent number: 9375442
    Abstract: This invention is directed to methods of treating solid tumor cancers, particularly refractory cancers by administration of two pluralities of microparticles, one comprising drug-carrying microparticles sized to lodge at the tumor preferably in the capillary bed of the tumor and the other comprising non-drug-carrying microparticles sized to lodge in the arterial system servicing the tumor so as to embolize the tumor.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: June 28, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Liangxuan Zhang, Florencia Lim
  • Patent number: 9358268
    Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: June 7, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Deborah Kilpatrick, Syed Faiyaz Ahmed Hossainy, Irina Astafieva, Florian N. Ludwig, Paul M. Consigny, Jeffrey T. Ellis, Florencia Lim
  • Publication number: 20160022449
    Abstract: Devices and methods for treating a diseased tracheobronchial region in a mammal. The device can be a stent which can include a sustained-release material such as a polymer matrix with a treatment agent. The stent can be bioabsorbable and a treatment agent can be incorporated therewith. A treatment method can be delivery of a stent to a tracheobronchial region by a delivery device such as a catheter assembly.
    Type: Application
    Filed: October 6, 2015
    Publication date: January 28, 2016
    Inventors: Florencia Lim, Mary Suh, Barbara Stamberg, Bin Huang
  • Publication number: 20150342581
    Abstract: A sealant is provided for sealing a puncture through tissue that comprises an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The first section comprises chitosan and at least one additional polymer. The second section may be formed from a solid mass of non-freeze-dried, non-cross-linked hydrogel precursors. The precursors are in an unreactive state until exposed to an aqueous physiological environment, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. The second section may further comprise chitosan. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
    Type: Application
    Filed: May 28, 2015
    Publication date: December 3, 2015
    Inventors: Andreas MYLONAKIS, Florencia LIM
  • Patent number: 9173733
    Abstract: Devices and methods for treating a diseased tracheobronchial region in a mammal. The device can be a stent which can include a sustained-release material such as a polymer matrix with a treatment agent. The stent can be bioabsorbable and a treatment agent can be incorporated therewith. A treatment method can be delivery of a stent to a tracheobronchial region by a delivery device such as a catheter assembly.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: November 3, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Florencia Lim, Mary Suh, Barbara Stamberg, Bin Huang
  • Patent number: 9119787
    Abstract: Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: September 1, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Florencia Lim, Mikael Trollsas, Michael Ngo, Thierry Glauser, Jinping Wan
  • Publication number: 20150174299
    Abstract: This invention is generally related to coating layers for implantable medical devices, such as drug delivery vascular stents, and methods of fabricating coated implantable medical devices. Specifically various embodiments of the present invention include methods of fabricating and modulating of coating layers to enhance bioabsorption. The coating layers include poly(ester-amide) and/or poly(amide) polymers.
    Type: Application
    Filed: December 15, 2014
    Publication date: June 25, 2015
    Inventors: MICHAEL HUY NGO, Syed Faiyaz Ahmed Hossainy, Florencia Lim, O. Mikael Trollsas