Patents by Inventor Florencio Dorwald

Florencio Dorwald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Glp-1 Derivatives
    Publication number: 20070203058
    Abstract: Novel polypeptide derivatives having protracted profile of action. The present invention relates to a compound which comprises a therapeutic polypeptide linked to an albumin binding residue via a hydrophilic spacer. The present invention also relates to a compound which comprises a therapeutic polypeptide linked to an albumin binding residue via a hydrophilic spacer that separates the polypeptide and the albumin binding residue with a chemical moiety comprising at least 5 non-hydrogen atoms where 30-50% of these atoms are either N or O.
    Type: Application
    Filed: September 17, 2004
    Publication date: August 30, 2007
    Applicant: NOVO NORDISK A/S
    Inventors: Jesper Lau, Thomas Hansen, Kjeld Madsen, Paw Bloch, Florencio Dorwald, Nils Johansen
  • Conjugation of peptides
    Publication number: 20070111926
    Abstract: Methods for the selective conjugation of peptides which comprises an enzymatic incorporation of a functional group at the C-terminal end of a peptide followed by reaction with a second compound comprising the moiety to be conjugated to the peptide, wherein said second compound comprises a functional group which selectively reacts with the incorporated functional group.
    Type: Application
    Filed: March 31, 2006
    Publication date: May 17, 2007
    Applicant: Novo Nordisk A/S
    Inventors: Magali Zundel, Bernd Peschke, Florencio Dorwald, Niels Fiil, Nils Johansen, Henning Stennicke
  • Transglutaminase mediated conjugation of peptides
    Publication number: 20070105770
    Abstract: Methods for conjugating peptides are provided comprising i) reacting a peptide with a first compound comprising a functional group in the presence of a transglutaminase capable of incorporating said compound into the peptide to form a transaminated peptide, and ii) reacting said transaminated peptide with e.g. a functionalized polymer capable of reacting with the functional group incorporated in the peptide in the enzymatic reaction.
    Type: Application
    Filed: July 11, 2006
    Publication date: May 10, 2007
    Applicant: Novo Nordisk A/S
    Inventors: Nils Johansen, Magali Zundel, Florencio Dorwald
  • Novel plasma protein affinity tags
    Publication number: 20070105750
    Abstract: Method for increasing half-life of therapeutic agents in plasma and novel polypeptide derivatives.
    Type: Application
    Filed: March 17, 2006
    Publication date: May 10, 2007
    Applicant: Novo Nordisk A/S
    Inventors: Florencio Dorwald, Bernd Peschke
  • IL-21 Derivatives and variants
    Publication number: 20060228331
    Abstract: The invention provides derivatives of IL-21 or variants thereof, methods of producing such variants, new variants of IL-21, and various methods of using such molecules.
    Type: Application
    Filed: April 10, 2006
    Publication date: October 12, 2006
    Applicant: Novo Nordisk A/S
    Inventors: Bernd Peschke, Christine Schiodt, Helle Woldike, Florencio Dorwald, Anne Worsaae
  • Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides
    Publication number: 20060182714
    Abstract: The invention provides synthesis and application of new structural well defined branched polymers as protraction agents for peptide and protein.
    Type: Application
    Filed: February 1, 2006
    Publication date: August 17, 2006
    Applicant: Novo Nordisk A/S
    Inventors: Carsten Behrens, Florencio Dorwald, Mikael Kofod-Hansen, Jesper Lau, Janos Kodra, Thomas Hansen, Paw Bloch