Patents by Inventor Florencio Zaragoza Doerwald

Florencio Zaragoza Doerwald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method For Preparation of Alkylated or Fluoro, Chloro and Fluorochloro Alkylated Compounds By Heterogeneous Catalysis
    Publication number: 20170158695
    Abstract: The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous Pt/C-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of Cs2C03 or CsHC03.
    Type: Application
    Filed: June 4, 2015
    Publication date: June 8, 2017
    Inventors: Christoph Taeschler, Matthias Beller, Helfried Neumann, Lin He, Kishore Natte, Stefan Ellinger, Florencio Zaragoza Doerwald
  • Method for preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone
    Patent number: 9663436
    Abstract: The invention discloses a method for the preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: May 30, 2017
    Assignee: Lonza Ltd
    Inventors: Florencio Zaragoza Doerwald, Christoph Taeschler
  • Method For Preparation of 4-Alkoxy-1,1,1-Trifluorobut-3-en-2-ones From 1,1,1-Trifluoroacetone
    Publication number: 20170137359
    Abstract: The invention discloses a method for the preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone.
    Type: Application
    Filed: June 24, 2015
    Publication date: May 18, 2017
    Inventors: Florencio Zaragoza Doerwald, Christoph Taeschler
  • METHOD FOR PREPARATION OF 6-TRIFLUOROMETHYLPYRIDINE-3-CARBOXYLIC ACID DERIVATIVES FROM TRIFLUOROACETYLACETIC ACID
    Publication number: 20160368876
    Abstract: The invention discloses a method for the preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives (I) from trifluoroacetylacetic acid (II) and orthoesters (III), and their use for the preparation of pharmaceutical, chemical or agro-chemical products.
    Type: Application
    Filed: July 17, 2014
    Publication date: December 22, 2016
    Inventors: Florencio Zaragoza Doerwald, Michael Bersier, Christoph Taeschler
  • Method for preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives from trifluoroacetylacetic acid
    Patent number: 9522885
    Abstract: The invention discloses a method for the preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives (I) from trifluoroacetylacetic acid (II) and orthoesters (III), and their use for the preparation of pharmaceutical, chemical or agro-chemical products.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: December 20, 2016
    Assignee: Lonza Ltd
    Inventors: Florencio Zaragoza Doerwald, Michael Bersier, Christoph Taeschler
  • Method for preparation of medetomidine with chloroacetone
    Patent number: 9434694
    Abstract: The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and chloroacetone.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: September 6, 2016
    Assignee: Lonza Ltd.
    Inventors: Florencio Zaragoza Doerwald, Anna Kulesza, Stephan Elzner, Robert Bujok, Zbigniew Wrobel, Krzysztof Wojciechowski
  • HAIR TREATMENT COMPOSITION
    Publication number: 20160220466
    Abstract: A hair treatment composition is described that contains an acetoacetylated compound. The acetoacetylated compound, for instance, can be a bis acetoacetylated compound. In one embodiment, for instance, the acetoacetylated compound comprises a bis acetoacetate or a bis acetoacetamide. In one embodiment, the hair treatment composition can be used to straighten hair. The composition is also well suited for decreasing hair frizz. The acetoacetylated compound is capable of crosslinking hair fibers upon the application of heat.
    Type: Application
    Filed: January 29, 2016
    Publication date: August 4, 2016
    Inventors: Paul Hanselmann, Florencio Zaragoza Doerwald
  • Method For Preparation of Medetomidine With Chloroacetone
    Publication number: 20150336909
    Abstract: The invention discloses a method for the preparation of medetomidine starting from 1-hromo 2,3-dimethylbenzene and chloroacetone.
    Type: Application
    Filed: July 30, 2015
    Publication date: November 26, 2015
    Inventors: Florencio Zaragoza Doerwald, Anna Kulesza, Stephan Elzner, Robert Bujok, Zbigniew Wrobel, Krzysztof Wojciechowski
  • Protein conjugates and methods for their preparation
    Patent number: 9175061
    Abstract: Reductive amination of peptide-derived aldehydes with anilines or heteroarylamines containing a property-modifying group provides new, hydrolytically stable protein conjugates, suitable for therapy.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: November 3, 2015
    Assignee: Novo Nordisk Health Care AG
    Inventor: Florencio Zaragoza Dörwald
  • Method for preparation of medetomidine with chloroacetone
    Patent number: 9156793
    Abstract: The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and chloroacetone.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: October 13, 2015
    Assignee: Lonza Ltd.
    Inventors: Florencio Zaragoza Doerwald, Anna Kulesza, Stephan Elzner, Robert Bujok, Zbigniew Wrobel, Krzysztof Wojciechowski
  • Process for the preparation of enolate salts of 4-fluoro-2-hydroxymethylene-3 oxo-butyrates
    Patent number: 9156771
    Abstract: Enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyrates of formula wherein R1 is C1-10 alkyl, R2 and R3 are independently hydrogen or fluorine, M is an alkali or alkaline earth metal, and n is 1 or 2, are prepared from enolate salts of the corresponding 4-fluoro-3-oxobutyrates and carbon monoxide. The enolate salts of formula I can be alkylated or acylated to obtain the corresponding enol ethers and esters. The 4-fluoro-3-oxobutyrate starting material can be prepared from 1,1-difluoroethyl methyl ethers by SbF5-catalyzed fluoromethane elimination followed by halogen exchange with lithium chloride, reacting the thus obtained fluoroacetyl chloride with ketene and quenching with the appropriate alcohol R1—OH.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: October 13, 2015
    Assignee: LONZA LTD
    Inventors: Martina Eichenberger, Paul Hanselmann, Florencio Zaragoza Dörwald
  • Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
    Patent number: 9126914
    Abstract: The invention discloses a method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal starting from 1-bromo 2,3-dimethylbenzene and chloroacetone, its use in perfumes and its use for the preparation of medetomidine.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: September 8, 2015
    Assignee: Lonza Ltd.
    Inventors: Florencio Zaragoza Doerwald, Anna Kulesza, Stephan Elzner, Robert Bujok, Zbigniew Wrobel, Krzysztof Wojciechowski
  • Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal
    Patent number: 9126915
    Abstract: The invention discloses a method for preparation of 2-(2,3-dimethylphenyl)-1-proponal from bromo 2,3-dimethyl-benzene and aceton, its use in perfumes and its use for the preparation of medetomidine.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: September 8, 2015
    Assignee: Lonza Ltd.
    Inventors: Florencio Zaragoza Doerwald, Anna Kulesza, Stephan Elzner, Robert Bujok, Zbigniew Wrobel, Krzysztof Wojciechowski
  • Method for preparation of octahydrocyclopenta[c]pyrrole
    Patent number: 9126930
    Abstract: The invention discloses a method for the preparation of octahydrocyclopenta[c]pyrrole, also called 3-azabicyclo[3.3.0]octane, by hydrogenation of 1,2-dicyanocyclo-1-pentene.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: September 8, 2015
    Assignee: Lonza Ltd.
    Inventor: Florencio Zaragoza Doerwald
  • METHOD FOR PREPARATION OF 2-(2,3-DIMETHYLPHENYL)-1-PROPANAL WITH CHLOROACETONE
    Publication number: 20150239816
    Abstract: The invention discloses a method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal starting from 1-bromo 2,3-dimethylbenzene and chloroacetone, its use in perfumes and its use for the preparation of medetomidine.
    Type: Application
    Filed: November 15, 2012
    Publication date: August 27, 2015
    Inventors: Florencio Zaragoza Doerwald, Anna Kulesza, Stephan Elzner, Robert Bujok, Zbigniew Wrobel, Krzysztof Wojciechowski
  • Method For Preparation of Octahydrocyclopenta[c]pyrrole
    Publication number: 20150183740
    Abstract: The invention discloses a method for the preparation of octahydrocyclopenta[c]pyrrole, also called 3-azabicyclo[3.3.0]octane, by hydrogenation of 1,2-dicyanocyclo-1-pentene.
    Type: Application
    Filed: January 3, 2013
    Publication date: July 2, 2015
    Inventor: Florencio Zaragoza Doerwald
  • Polypeptide protracting tags
    Patent number: 9061067
    Abstract: The invention relates to methods for increasing the plasma half-life of a molecule, such as human growth hormone, comprising covalently linking the molecule to a heterocyclic carboxylic acid bioisostere.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: June 23, 2015
    Assignee: Novo Nordisk A/S
    Inventors: Florencio Zaragoza Dörwald, Christine Bruun Schiødt, Thomas Kruse Hansen, Kjeld Madsen
  • Method for preparation of medetomidine
    Patent number: 9045433
    Abstract: The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and aceton.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: June 2, 2015
    Assignee: Lonza Ltd.
    Inventors: Florencio Zaragoza Doerwald, Anna Kulesza, Stephan Elzner, Robert Bujok, Zbigniew Wrobel, Krzysztof Wojciechowski
  • METHOD FOR PREPARATION OF MEDETOMIDINE WITH CHLOROACETONE
    Publication number: 20150099889
    Abstract: The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and chloroacetone.
    Type: Application
    Filed: November 15, 2012
    Publication date: April 9, 2015
    Inventors: Florencio Zaragoza Doerwald, Anna Kulesza, Stephen Elzner, Robert Bujok, Zbigniew Wrobel, Krzysztof Wojciechowski
  • METHOD FOR PREPARATION OF 2-(2,3-DIMETHYLPHENYL)-1-PROPANAL
    Publication number: 20150080287
    Abstract: The invention discloses a method for preparation of 2-(2,3-dimethylphenyl)-1-proponal from bromo 2,3-dimethyl-benzene and aceton, its use in perfumes and its use for the preparation of medetomidine.
    Type: Application
    Filed: November 15, 2012
    Publication date: March 19, 2015
    Inventors: Florencio Zaragoza Doerwald, Anna Kulesza, Stephan Elzner, Robert Bujok, Zbigniew Wrobel, Krzysztof Wojciechowski