Patents by Inventor Florent Soubrier

Florent Soubrier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to determine predisposition to hypertension
    Patent number: 6165727
    Abstract: The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: December 26, 2000
    Assignees: University of Utah Research Foundation, Inserm
    Inventors: Jean-Marc Lalouel, Xavier Jeunemaitre, Richard P. Lifton, Florent Soubrier, Youri Kotelevtsev, Pierre Corvol
  • Method to determine predisposition to hypertension
    Patent number: 5998145
    Abstract: The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood pressure.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: December 7, 1999
    Assignees: Univ. of Utah Research Foundation, INSERM
    Inventors: Jean-Marc Lalouel, Xavier Jeunemaitre, Richard P. Lifton, Florent Soubrier, Youri Kotelevtsev, Pierre Corvol
  • Nucleic acid coding for the human testicular angiotensin converting enzyme (ACE ) and its uses, especially for the in vitro screening for this enzyme in the organism
    Patent number: 5801040
    Abstract: The object of the invention is the cloning and sequencing of the nucleic acid coding for the human testicular ACE as well as the determination of the peptide sequence of this ACE.It relates more particularly to the use of nucleotide probes capable of hybridizing with all or part of the above-mentioned nucleic acid, and also the polyclonal or monoclonal antibodies recognizing specifically all or part of the above-mentioned peptide sequence, and the use of these probes or these antibodies for the implementation, respectively, of a method for the detection of the messenger RNA coding for the testicular ACE in vitro or of the testicular ACE directly.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 1, 1998
    Assignee: Institut National de la Sante et de la Recherche Medicale
    Inventors: Florent Soubrier, Fran.cedilla.ois Alhenc-Gelas, Christine Hubert
  • Method to determine predisposition to hypertension
    Patent number: 5763168
    Abstract: The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: June 9, 1998
    Assignees: University of Utah Research Foundation, INSERM
    Inventors: Jean-Marc Lalouel, Xavier Jeunemaitre, Richard P. Lifton, Florent Soubrier, Youri Kotelevtsev, Pierre Corvol
  • Agents and procedures for the study of the genetic polymorphism of the angiotensin I converting enzyme
    Patent number: 5736323
    Abstract: The invention discloses a method for detecting polymorphism in the angiotensin converting enzyme by means of a chain amplification technique, the aim being to detect whether or not the sequence of nucleotides 1451-1738 of intron 16 is present in the human angiotensin converting enzyme gene.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: April 7, 1998
    Assignee: Institut National de la Sante et de la Recherche Medicale
    Inventors: Florent Soubrier, Christine Hubert, Pierre Corvol
  • Angiotensinogen gene variants and predisposition to hypertension
    Patent number: 5589584
    Abstract: The association of molecular variants of the angiotensinogen gene with human essential hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: December 31, 1996
    Assignee: University of Utah Research Foundation
    Inventors: Jean-Marc Lalouel, Xavier Jeunemaitre, Richard P. Lifton, Florent Soubrier, Youri Kotelevtsev, Pierre Corvol
  • Nucleic acid coding for the human angiotensin converting enzyme (ACE), and its uses, especially for the in vitro diagnosis of arterial hypertension
    Patent number: 5480793
    Abstract: The invention relates to the cloning and sequencing of the nucleic acid coding for the human ACE as well as the determination of the peptide chain corresponding to the ACE and of active peptide fragments which derive from it.Another subject of the invention is the utilization of the above-mentioned polypeptides for the implementation of in vitro diagnostic methods for hypertension and for the design of new inhibitors of the ACE.The invention also relates to the utilization of the nucleotide probes of the invention for the in vitro screening of the polymorphisms of the gene coding for the ACE.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: January 2, 1996
    Assignee: Institut National De La Sante Et De La Recherche Medicale
    Inventors: Florent Soubrier, Francois Alhenc-Gelas, Christine Hubert, Pierre Corvol
  • Nucleic acid coding for the human angiotensin converting enzyme (ACE), and its uses, especially for the in vitro diagnosis of arterial hypertension
    Patent number: 5359045
    Abstract: The invention relates to the cloning and sequencing of the nucleic acid coding for the human ACE as well as the determination of the peptide chain corresponding to the ACE and of active peptide fragments which derive from it.Another subject of the invention is the utilization of the above-mentioned polypeptides for the implementation of in vitro diagnostic methods for hypertension and for the design of new inhibitors of the ACE.The invention also relates to the utilization of the nucleotide probes of the invention for the in vitro screening of the polymorphisms of the gene coding for the ACE.
    Type: Grant
    Filed: May 23, 1990
    Date of Patent: October 25, 1994
    Assignee: Institut National de la Sante et de la Recherche Medicale
    Inventors: Florent Soubrier, Francois Alhenc-Gelas, Christine Hubert, Pierre Corvol