Abstract: The present disclosure is directed to thiazolopyridin-7(4h)-one based compounds, including compounds of Formula I i.e., the isomeric 4H-[1,3]thiazolo[4,5-b]pyridin-7-one or 4H-[1,3]thiazolo[5,4-b]pyridin-7-one compounds, and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein, particularly cancers characterized as microsatellite instability-high or mismatch repair deficient (dMMR).

Abstract: The present disclosure is directed to oxazolopyridin-7(4H)-one based compounds, including compounds of Formula (I): (Formula (I)) and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The present disclosure is directed to cyclic sulfone-containing compounds, including compounds of Formula I: (I) pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The present disclosure is directed to compounds of Formula I: and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The present disclosure is directed to compounds of Formula I: and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The present disclosure is directed to compounds of Formula I: and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The present disclosure is directed to compounds of Formula II-e: and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The present disclosure is directed to compounds of Formula I: and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The present disclosure is directed to compounds of Formula I: and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The present disclosure is directed to compounds of Formula II-e: and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The present disclosure is directed to compounds of Formula I. and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The present disclosure is directed to triazolo based compounds, including compounds of Formula I: and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The present disclosure is directed to compounds of Formula I: and pharmaceutically acceptable salts thereof, and compositions thereof, as well as methods of treatment of cancers such as those involving WRN protein.

Abstract: The invention relates to a navigation method and to a navigation device. In the navigation method, the actual movement of the navigation device and thus of the user of the navigation device is detected. In order for a prescribed destination to be reached, navigation instructions are output by the navigation device. Signals that reflect the actual geometry of the surroundings can be transmitted to the navigation device by a device for detecting the surroundings. If it is recognized that output navigation instructions have not been followed, then the signals that reflect the geometry of the surroundings are detected. Based on the difference between the actual movement and the movement prescribed by the instructions, alternative navigation instructions are determined. In comparison to the originally suggested navigation instructions, the alternative navigation instructions constitute a confirmation in the direction of movement suggested by the original navigation instructions.

Abstract: A technique is described for providing travel information for route segments repeatedly covered by a vehicle, wherein the travel information is indicative of map data changes extractable from map data update information. A method aspect comprises the steps of determining whether the vehicle is likely to travel along repeatedly covered route segments; selecting map data changes that are associated with the repeatedly covered route segments the vehicle is likely to travel; and generating travel information on basis of the selected map data changes and providing the travel information to a driver. Provided are also a computer program product and a device implementing the described method.

Abstract: A method for operating a navigation device. The navigation device carries out a position determination on the basis of received signals. In parallel, another position determination is carried out on the basis of signals from inertial sensors. These two determined positions are compared. If these two determined positions differ by more than a predetermined amount, which has been defined by a predetermined limit value, an error value is recognized. If an impermissible deviation is recognized, then especially the direction of movement, the speed differences and the position changes are taken into account. When the error value is recognized, shaded areas in the surroundings of the vehicle are determined and associated with the determined momentary position, as a result of which an association with a lane level is carried out.

Abstract: The invention relates to a navigation method and to a navigation device. In the navigation method, the actual movement of the navigation device and thus of the user of the navigation device is detected. In order for a prescribed destination to be reached, navigation instructions are output by the navigation device. Signals that reflect the actual geometry of the surroundings can be transmitted to the navigation device by a device for detecting the surroundings. If it is recognized that output navigation instructions have not been followed, then the signals that reflect the geometry of the surroundings are detected. Based on the difference between the actual movement and the movement prescribed by the instructions, alternative navigation instructions are determined. In comparison to the originally suggested navigation instructions, the alternative navigation instructions constitute a confirmation in the direction of movement suggested by the original navigation instructions.

Abstract: A technique for calibrating sensor data used for dead reckoning positioning comprises the steps of simultaneously recording sensor data of at least one dead reckoning positioning sensor and position data of a position sensor during travel, comparing a first travel path derived from the position data with a second travel path derived from the sensor data, and calibrating the sensor data based on the comparison.

Abstract: A method for operating a navigation device. The navigation device carries out a position determination on the basis of received signals. In parallel, another position determination is carried out on the basis of signals from inertial sensors. These two determined positions are compared. If these two determined positions differ by more than a predetermined amount, which has been defined by a predetermined limit value, an error value is recognized. If an impermissible deviation is recognized, then especially the direction of movement, the speed differences and the position changes are taken into account. When the error value is recognized, shaded areas in the surroundings of the vehicle are determined and associated with the determined momentary position, as a result of which an association with a lane level is carried out.

Abstract: The present invention relates to an apparatus for laser cladding of a curved surface comprising: (a) an elongated arm having first and second ends and defining a chamber through the arm from the first end to the second end; (b) a laser delivery source connected to a focusing lens mounted in a housing within an opening on the first end of the arm for delivering a laser beam through the chamber; (c) a delivery head mounted on the second end of the arm comprised of (i) an enclosure having an inlet for receiving the laser and an outlet for delivering the laser to the curved surface, (ii) a powder nozzle for delivering a cladding powder to an inner surface of the curved surface, and (iii) a reflective surface for reflecting the laser to exit through the outlet; (d) mounting means for rotating the curved surface for the cladding of the curved surface; and (e) indexing means for moving the arm substantially parallel to a longitudinal axis of the curved surface so as to clad the curved surface during the rotation of