Abstract: Sensors employing bulk acoustic wave (BAW) resonators are used to assay characteristics of blood. The BAW sensors may be used to sense viscosity of a sample comprising blood to determine coagulation properties of the blood. The viscosity of the blood may be evaluated in the presence of agents that inhibit coagulation or that promote coagulation. The change in viscosity of the sample in the presence of such agents may provide information regarding whether the blood suffers from a coagulation disorder.

Abstract: A device including at least one sensing bulk acoustic wave (BAW) resonator including a sensing surface; a fluid channel, wherein the sensing surface of the at least one sensing BAW resonator is disposed adjacent to or within the fluid channel; at least one resistive heater; and at least one temperature detector, wherein the at least one temperature detector is configured to monitor the temperature adjacent to the at least one BAW resonator and affect a current to be passed through the at least one resistive heater.

Abstract: A cartridge for sample handling and sensing includes (i) a sample port; (ii) a first fluid port connected to the sample reservoir in the distal region via a first fluid channel; and (iii) a second fluid port connected to the sample reservoir via a second fluid channel. The cartridge includes (i) a sensor platform comprising a bulk acoustic wave (BAW) resonator and a fluid flow path comprising a sensing region extending across a sensing surface of the BAW resonator; and (ii) a fluid valve between the sample reservoir and the sensing region. A sample may be applied to the sample port; first volume of fluid may be injected through the first fluid port; and then a second volume of fluid may be injected through the second fluid port to drive the sample into the sensing region of the fluid flow path.

Abstract: A device including at least one sensing bulk acoustic wave (BAW) resonator including a sensing surface; a fluid channel, wherein the sensing surface of the at least one sensing BAW resonator is disposed adjacent to or within the fluid channel; at least one resistive heater; and at least one temperature detector, wherein the at least one temperature detector is configured to monitor the temperature adjacent to the at least one BAW resonator and affect a current to be passed through the at least one resistive heater.

Abstract: A sampler for acquiring and transporting sample material may include a sampler body defining a sampling volume configured to hold the sample material. The sampler body may define a sample port that may be used as an entrance to collect the sample material and an exit to expel the sample material. The sample port may be configured to be operably connected to a fluidic channel of a cartridge. The sampler may also define a pump connection port configured to be operably connected to a pump. The pump may force the sample material out of the sampling volume through the sample port.

Abstract: Sensors employing bulk acoustic wave (BAW) resonators are used to assay characteristics of blood. The BAW sensors may be used to sense viscosity of a sample comprising blood to determine coagulation properties of the blood. The viscosity of the blood may be evaluated in the presence of agents that inhibit coagulation or that promote coagulation. The change in viscosity of the sample in the presence of such agents may provide information regarding whether the blood suffers from a coagulation disorder.

Abstract: Sensors employing bulk acoustic wave (BAW) resonators are used to assay characteristics of blood. The BAW sensors may be used to sense viscosity of a sample comprising blood to determine coagulation properties of the blood. The viscosity of the blood may be evaluated in the presence of agents that inhibit coagulation or that promote coagulation. The change in viscosity of the sample in the presence of such agents may provide information regarding whether the blood suffers from a coagulation disorder.

Abstract: A cartridge for sample handling and sensing includes a sample port connected to a sample reservoir having a proximal end, a proximal region adjacent the proximal end, and a distal end opposite of the proximal end. The cartridge also includes a first fluid port connected to the sample reservoir in the distal region via a first fluid channel; and a second fluid port connected to the sample reservoir in the proximal region via a second fluid channel. In addition, the cartridge includes a sensor platform comprising a bulk acoustic wave (BAW) resonator and a fluid flow path comprising a sensing region extending across a sensing surface of the BAW resonator. The cartridge further includes a fluid valve between the distal end of the sample reservoir and the sensing region.

Abstract: Systems, methods, and apparatuses for microarray mixing are provided. In one embodiment, a system comprises a microarray having one or more vibration motors coupled thereto, and psuedo-random voltage signals are provided to the vibration motors to agitate the microarray. In this way, the size of a microarray mixer can be reduced while avoiding standing wave artifacts in the microarray background.

Abstract: A device for measuring a resistance includes a comparator. A D-type flip-flop has its D input connected to the output of the comparator and its latch input connected for receiving a pulse signal at a fixed pulse repetition rate. A reference voltage source is connected to a first of the inputs of the comparator and an integrator is coupled between an output of the flip-flop and the second of the two inputs of the comparator. The integrator includes a resistor whereby the integrator develops a voltage at the second input of the comparator that depends on the pulse repetition rate and on the resistance of the resistor. The comparator, the integrator and the flip-flop are connected in a negative feedback loop such that at steady state the voltage developed by the integrator at the second input of the comparator is substantially equal to the reference voltage.