Patents by Inventor Florian Eichler

Florian Eichler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ABCD1 FOR TREATMENT OF NEURODISORDERS
    Publication number: 20230365967
    Abstract: Methods of the invention encompass delivery of nucleic acid sequences encoding ABCD1 for the treatment of X-linked Adrenoleukodystrophy (X-ALD), e.g., for Adrenomyeloneuropathy (AMN).
    Type: Application
    Filed: April 4, 2023
    Publication date: November 16, 2023
    Inventors: Casey A. Maguire, Florian Eichler, Yi Gong
  • METHODS FOR IDENTIFYING AND TREATING ADRENOMYELONEUROPATHY (AMN)
    Publication number: 20200309788
    Abstract: Provided herein is a method of detecting adrenomyeloneuropathy (AMN) in a human male subject, said method comprising determining the level of MFGE8, C1qa, Trem2, Gas6 or any combination thereof, in a biological sample obtained from the spine of the subject, wherein said level or levels are increased compared to a reference level or levels, thereby detecting AMN in the subject. Also provided is a method of treating AMN in a human male subject, said method comprising administering an anti-MFGE8 antibody to the subject.
    Type: Application
    Filed: October 1, 2018
    Publication date: October 1, 2020
    Inventors: Florian Eichler, Yi Gong
  • Intrathecal delivery of nucleic acid sequences encoding ABCD1 for treatment of adrenomyeloneuropathy
    Patent number: 10519445
    Abstract: Methods of the invention encompass delivery of nucleic acid sequences encoding ABCD1 for the treatment of X-linked Adrenoleukodystrophy (X-ALD), e.g., for Adrenomyeloneuropathy (AMN).
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: December 31, 2019
    Assignee: The General Hospital Corporation
    Inventors: Casey A. Maguire, Florian Eichler
  • INTRATHECAL DELIVERY OF NUCLEIC ACID SEQUENCES ENCODING ABCD1 FOR TREATMENT OF ADRENOMYELONEUROPATHY
    Publication number: 20190225967
    Abstract: Methods of the invention encompass delivery of nucleic acid sequences encoding ABCD1 for the treatment of X-linked Adrenoleukodystrophy (X-ALD), e.g., for Adrenomyeloneuropathy (AMN).
    Type: Application
    Filed: April 2, 2019
    Publication date: July 25, 2019
    Inventors: Casey A. Maguire, Florian Eichler
  • INTRATHECAL DELIVERY OF NUCLEIC ACID SEQUENCES ENCODING ABCD1 FOR TREATMENT OF ADRENOMYELONEUROPATHY
    Publication number: 20180320176
    Abstract: Methods of the invention encompass delivery of nucleic acid sequences encoding ABCD1 for the treatment of X-linked Adrenoleukodystrophy (X-ALD), e.g., for Adrenomyeloneuropathy (AMN).
    Type: Application
    Filed: November 3, 2016
    Publication date: November 8, 2018
    Inventors: Casey A. Maguire, Florian Eichler