Patents by Inventor Florian FLEISCHHACKER

Florian FLEISCHHACKER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Artificial non-ribosomal peptide synthases and their use
    Patent number: 11643643
    Abstract: The present invention pertains to a novel architecture of non-ribosomal peptide synthases (NRPS). The invention provides artificial NRPS wherein the naturally occurring terminal condensation or thioesterase-domain is replaced by internal condensation or dual condensation/epimerization domains. Moreover, the present invention enables the portability of terminal condensation domains to unrelated NRPS in respect of peptide release of linear peptides. The replacement results in a product independent release of the synthesized product and therefore enables the rational design of NRPS. The invention provides the new NRPS, nucleic acids encoding them, methods for artificial NRPS generation, and methods for producing non-ribosomal peptides.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: May 9, 2023
    Assignee: Johann Wolfgang Goethe-Universität Frankfurt am Main
    Inventors: Helge B. Bode, Kenan Bozhüyük, Florian Fleischhacker
  • Artificial non-ribosomal peptide synthetases
    Patent number: 11473078
    Abstract: The present invention concerns a novel method for the modification and/or custom-made design of artificial non-ribosomal peptide synthetases (NRPSs) from naturally available NRPSs. The artificial NRPSs are of predetermined length and amino acid composition and sequence. Via fusion of well-defined NRPS units (so-called “exchange units”) in a certain manner, using a specific sequence motif in the linker areas it is possible to construct artificial and/or modified NRPS assembly lines, which have the ability of synthesizing peptides of a desired structure.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: October 18, 2022
    Assignee: JOHANN WOLFGANG GOETHE-UNIVERSITAT
    Inventors: Claus-Peter Niesert, Helge B. Bode, Kenan Bozhueyuek, Florian Fleischhacker
  • ARTIFICIAL NON-RIBOSOMAL PEPTIDE SYNTHASES AND THEIR USE
    Publication number: 20200181598
    Abstract: The present invention pertains to a novel architecture of non-ribosomal peptide synthases (NRPS). The invention provides artificial NRPS wherein the naturally occurring terminal condensation or thioesterase-domain is replaced by internal condensation or dual condensation/epimerization domains. Moreover, the present invention enables the portability of terminal condensation domains to unrelated NRPS in respect of peptide release of linear peptides. The replacement results in a product independent release of the synthesized product and therefore enables the rational design of NRPS. The invention provides the new NRPS, nucleic acids encoding them, methods for artificial NRPS generation, and methods for producing non-ribosomal peptides.
    Type: Application
    Filed: February 8, 2017
    Publication date: June 11, 2020
    Inventors: Helge B. BODE, Kenan BOZHÜYÜK, Florian FLEISCHHACKER
  • ARTIFICIAL NON-RIBOSOMAL PEPTIDE SYNTHETASES
    Publication number: 20180230449
    Abstract: The present invention concerns a novel method for the modification and/or custom-made design of artificial non-ribosomal peptide synthetases (NRPSs) from naturally available NRPSs. The artificial NRPSs are of predetermined length and amino acid composition and sequence. Via fusion of well-defined NRPS units (so-called “exchange units”) in a certain manner, using a specific sequence motif in the linker areas it is possible to construct artificial and/or modified NRPS assembly lines, which have the ability of synthesizing peptides of a desired structure.
    Type: Application
    Filed: July 6, 2016
    Publication date: August 16, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Claus-Peter NIESERT, Helge B. BODE, Kenan BOZHUEYUEK, Florian FLEISCHHACKER