Abstract: The present disclosure relates to a compound of Formula (I): (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein Ring A, and R1 through R4 are as defined herein, and methods of making and using the same.

Abstract: The present disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein R1 through R8 are as defined herein, and methods of making and using the same.

Abstract: Disclosed is a device for processing plastic materials, having a shredding unit, a conveying unit having a screw (7), and an extruder, having at least one extruder screw (11), adjoining the screw, wherein the central longitudinal axis (3) of the screw (7) is oriented at an angle to the central longitudinal axis (10) of the extruder screw (11), in particular at an angle of 80° to 100°, preferably 90°, and the longitudinal axis (3) of the screw (7) is offset with respect to the longitudinal axis (10) of the extruder screw (11) by an offset (v) in the direction of the direction of rotation (12) of the extruder screw (11) at or in the region of the discharge opening (8) or the intake opening (16) of the conveying unit.

Abstract: The present disclosure describes a heat exchanger of a motor vehicle that is supplied with a cooling air mass flow that changes depending on a travelling speed of the motor vehicle. The heat exchanger includes a heat exchanger block with a plurality of flat tubes that are each received on a longitudinal end side in an associated passage opening of a tube sheet and provide a coolant path. A tank is connected to the tube sheet and defines a coolant header. An additional element is arranged on an outer edge or on an outer marginal region of the tube sheet. The additional element is structured and arranged to provide an at least partial covering of the tube sheet relative to an inflow side, e.g., relative to the cooling air mass flow.

Abstract: The invention relates to a composition comprising one or more inhibitors capable of inhibiting at least two of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and lipoxygenase or a composition comprising one or more inhibitors capable of inhibiting an enzyme with arachidonate-Co A ligase activity, specifically long-chain-fatty-acid-Co A ligase (ACSL) 1, ACSL3, ACSL4, ACSL5, ACSL6, SLC27A2 or ACSBG2, or a combination thereof for use in selectively eliminating senescent cells. The invention further relates to an in vitro method of identifying senescent cells in a subject and to a method of identifying candidate compounds for the selective elimination of senescent cells.

Abstract: A device for detecting or evaluating articles or products, irradiated by a laser beam, for generation of Raman or fluorescence radiation on surfaces of them, and generated radiation is directed to a detector array designed for locally resolved detection of the radiation. Monochromatic electromagnetic radiation with no influence on Raman or fluorescence radiation is directed at the articles or products. Detectors detect radiation reflected or scattered by articles or products in a locally resolved manner. An optical filter or beam splitter is arranged between articles or products and detector array. Irradiation and detection are carried out during relative movement between articles or products, focal range of the laser beam, diodes emitting electromagnetic radiation and detectors of the detector array. Detectors are connected to an electronic evaluation unit designed for locally and spectrally resolved evaluation of detected intensities of Raman or fluorescence radiation and for image analysis.

Abstract: In the arrangement for determining the achievable adhesive strength before forming a connection having material continuity to a surface of a joining partner, a plurality of detectors are present and arranged that are configured for a spatially resolved spectral analysis of electromagnetic radiation within a wavelength interval and are connected to an electronic evaluation unit. They can detect radiation emitted from a broadband radiation source of a reflection incident on the surface of one of the joining partners, and/or after passing through joining partners transparent for the electromagnetic radiation on the detectors. A laterally and temporally homogeneous intensity of the electromagnetic radiation should be observed in this respect. The joining partner is formed from a material that does not 100% absorb the respective electromagnetic radiation and thus a transmission and/or reflection is possible.

Abstract: The present disclosure describes a heat exchanger of a motor vehicle that is supplied with a cooling air mass flow that changes depending on a travelling speed of the motor vehicle. The heat exchanger includes a heat exchanger block with a plurality of flat tubes that are each received on a longitudinal end side in an associated passage opening of a tube sheet and provide a coolant path. A tank is connected to the tube sheet and defines a coolant header. An additional element is arranged on an outer edge or on an outer marginal region of the tube sheet. The additional element is structured and arranged to provide an at least partial covering of the tube sheet relative to an inflow side, e.g., relative to the cooling air mass flow.

Abstract: The invention relates to an assembly for determining the permeation rate of a sample for at least one permeate, in particular water vapor, wherein multiple detectors are arranged in a row or in a row and column arrangement for the spatially resolved spectral analysis of electromagnetic radiation within a wavelength interval. The detectors are connected to an electronic evaluation unit and are arranged such that electromagnetic radiation emitted from a broadband radiation source is incident on the detectors either after being reflected by the surface of the sample, by a layer formed on the sample, or by the surface of a layer within the sample, and/or after passing through a sample which is transparent to the electromagnetic radiation. The irradiation is carried out such that a homogeneous intensity of the electromagnetic radiation is maintained on a surface, by means of which the electromagnetic radiation is reflected or through which the radiation is transmitted.

Abstract: The invention relates to an assembly for determining the permeation rate of a sample for at least one permeate, in particular water vapor, wherein multiple detectors are arranged in a row or in a row and column arrangement for the spatially resolved spectral analysis of electromagnetic radiation within a wavelength interval. The detectors are connected to an electronic evaluation unit and are arranged such that electromagnetic radiation emitted from a broadband radiation source is incident on the detectors either after being reflected by the surface of the sample, by a layer formed on the sample, or by the surface of a layer within the sample, and/or after passing through a sample which is transparent to the electromagnetic radiation. The irradiation is carried out such that a homogeneous intensity of the electromagnetic radiation is maintained on a surface, by means of which the electromagnetic radiation is reflected or through which the radiation is transmitted.

Abstract: An arrangement for determining characteristics or parameters of a sample, or a layer formed on or in the sample, has detectors, spatially resolving spectral analysis of electromagnetic radiation within a wavelength interval, provided in rows or in a row and column arrangement, whereby electromagnetic radiation emitted from a broadband radiation source is incident on the detectors after reflecting off, and/or passing through, the sample, or layer formed on or in the sample, upon which is observed a homogeneous intensity of the electromagnetic radiation, and an electronic evaluation unit connected to the detectors compares the spatially-resolved and wavelength-resolved signals detected by the detectors with a theoretical wavelength dependent progression of the respective radiation intensities obtained through simulation or with a progression obtained by calibration on a known sample, in order to obtain information for the measurement position detected, and determine the spatially-resolved distribution of the ch

Abstract: An alcoholic extract of aerial parts of Solidago virgaurea subsp. alpestris, the method of production thereof, a cosmetic or dermatological composition containing it, as well as cosmetic and dermatological uses thereof, notably in the treatment of signs of skin ageing.

Abstract: In the arrangement for determining the achievable adhesive strength before forming a connection having material continuity to a surface of a joining partner, a plurality of detectors are present and arranged that are configured for a spatially resolved spectral analysis of electromagnetic radiation within a wavelength interval and are connected to an electronic evaluation unit. They can detect radiation emitted from a broadband radiation source of a reflection incident on the surface of one of the joining partners, and/or after passing through joining partners transparent for the electromagnetic radiation on the detectors. A laterally and temporally homogeneous intensity of the electromagnetic radiation should be observed in this respect. The joining partner is formed from a material that does not 100% absorb the respective electromagnetic radiation and thus a transmission and/or reflection is possible.

Abstract: The invention relates to an arrangement for determining properties and/or parameters of a sample and/or of at least one film formed on a surface of a sample. In this respect, a plurality of detectors are arranged in a row arrangement or in a row and column arrangement and are configured for the spatially resolved spectral analysis of electromagnetic radiation within a wavelength interval. The detectors are connected to an electronic evaluation unit and are arranged such that electromagnetic radiation emitted by a broadband radiation source is incident onto the detectors either after a reflection at the surface of the sample or at a film formed on the sample or at the surface of a film within the sample and/or after passing through a sample transparent to the electromagnetic radiation. The irradiation takes place such that a homogenous intensity of the electromagnetic radiation is observed on a surface from which the electromagnetic radiation is reflected or is transmitted by the surface.

Abstract: An alcoholic extract of aerial parts of Solidago virgaurea subsp. alpestris, the method of production thereof, a cosmetic or dermatological composition containing it, as well as cosmetic and dermatological uses thereof, notably in the treatment of signs of skin ageing.

Abstract: The present invention relates to a method for producing an extract which is capable of inducing an antioxidant stress response comprising the step of treating an extract from organic material with UV light, said extract being derived from a non-mammalian cell or a non-mammalian organism and said cell or organism being capable of synthesizing polyunsaturated fatty acids. Furthermore, an extract capable of inducing an antioxidant stress response produced in accordance with the inventive methods, in particular an extract capable of inducing an antioxidant stress response for the preparation of a cosmetic composition is disclosed. The present invention also relates to a cosmetic composition comprising the inventive extract obtainable by the method provided herein.

Abstract: Interaction of the PAI-1 promotor region with NAK-1 was twice detected using a genetic screen.