Patents by Inventor FLORIAN JAKOB

FLORIAN JAKOB has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted condensed pyrimidine compounds
    Patent number: 9670189
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: June 6, 2017
    Assignee: GRÜNENTHAL GMBH
    Inventors: Ingo Konetzki, Florian Jakob, Tobias Craan, Christian Hesslinger, Paul Ratcliffe, Jason J. Shiers
  • HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES
    Publication number: 20170121314
    Abstract: The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: January 12, 2017
    Publication date: May 4, 2017
    Applicant: GRÜNENTHAL GMBH
    Inventors: STEFAN SCHUNK, Melanie Reich, Florian Jakob, Nils Damann, Michael Haurand, Achim Kless, Marc Rogers, Kathy Sutton
  • Novel 2,5-substituted pyrimidines
    Publication number: 20170065603
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: November 17, 2016
    Publication date: March 9, 2017
    Inventors: Antonio NARDI, Florian JAKOB, Ingo KONETZKI, Tobias CRAAN, Christian HESSLINGER
  • Novel substituted pyrimidine compounds
    Publication number: 20170066776
    Abstract: The invention relates to novel substituted pyrimidine compounds of general formula (I) in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: November 17, 2016
    Publication date: March 9, 2017
    Inventors: Antonio NARDI, Florian JAKOB, Ingo KONETZKI, Tobias CRAAN, Christian HESSLINGER, Robin DOODEMAN
  • Fluoromethyl-substituted pyrrole carboxamides as CaV2.2 calcium channel blockers
    Patent number: 9562036
    Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: February 7, 2017
    Assignee: GRÜNENTHAL GMBH
    Inventors: Melanie Reich, Stefan Schunk, Florian Jakob, Henning Steinhagen, Nils Damann, Michael Haurand, Marc Rogers, Kathy MacKenzie
  • 2,5-substituted pyrimidines
    Patent number: 9546158
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: January 17, 2017
    Assignee: GRUENENTHAL GMBH
    Inventors: Antonio Nardi, Florian Jakob, Ingo Konetzki, Tobias Craan, Christian Hesslinger
  • Substituted pyrimidine compounds
    Patent number: 9540349
    Abstract: The invention relates to novel substituted pyrimidine compounds of general formula (I) in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: January 10, 2017
    Assignee: GRUENENTHAL GMBH
    Inventors: Antonio Nardi, Florian Jakob, Ingo Konetzki, Tobias Craan, Christian Hesslinger
  • Substituted condensed pyrimidine compounds
    Patent number: 9527832
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: December 27, 2016
    Assignee: GRÜNENTHAL GMBH
    Inventors: Ingo Konetzki, Florian Jakob, Tobias Craan, Christian Hesslinger, Paul Ratcliffe, Antonio Nardi
  • 4-amino substituted condensed pyrimidine compounds as PDE4 inhibitors
    Patent number: 9505724
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: November 29, 2016
    Assignee: GRÜNENTHAL GMBH
    Inventors: Ingo Konetzki, Florian Jakob, Tobias Craan, Christian Hesslinger
  • FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES IV
    Publication number: 20160297803
    Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: June 14, 2016
    Publication date: October 13, 2016
    Inventors: Melanie REICH, Stefan SCHUNK, Florian JAKOB, Henning STEINHAGEN, Nils DAMANN, Michael HAURAND, Richard HAMLYN, Marc ROGERS, Kathy MACKENZIE
  • FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES III
    Publication number: 20160289186
    Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: June 14, 2016
    Publication date: October 6, 2016
    Inventors: Melanie REICH, Stefan SCHUNK, Florian JAKOB, Nils DAMANN, Michael HAURAND, Richard HAMLYN, Marc ROGERS, Kathy MACKENZIE, Philip SKONE
  • FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES AS CAV2.2 CALCIUM CHANNEL BLOCKERS
    Publication number: 20160289214
    Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: June 17, 2016
    Publication date: October 6, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Melanie REICH, Stefan SCHUNK, Florian JAKOB, Henning STEINHAGEN, Nils DAMANN, Michael HAURAND, Marc ROGERS, Kathy MACKENZIE
  • NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS
    Publication number: 20160152624
    Abstract: Novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: February 9, 2016
    Publication date: June 2, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Florian JAKOB, Ingo KONETZKI, Tobias CRAAN, Antonio NARDI, Christian HESSLINGER
  • 2,5-substituted pyrimidines
    Patent number: 9315490
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: April 19, 2016
    Assignee: GRUENENTHAL GMBH
    Inventors: Ingo Konetzki, Tobias Craan, Florian Jakob, Antonio Nardi, Christian Hesslinger, Andre Welbers
  • NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS
    Publication number: 20160031857
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: October 15, 2015
    Publication date: February 4, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Ingo KONETZKI, Florian JAKOB, Tobias CRAAN, Christian HESSLINGER, Paul RATCLIFFE, Antonio NARDI
  • Novel 2,5-Substituted Pyrimidines
    Publication number: 20160024053
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 28, 2016
    Inventors: Ingo KONETZKI, Tobias CRAAN, Florian JAKOB, Antonio NARDI, Christian HESSLINGER, Andre WELBERS
  • Novel substituted pyrimidine compounds
    Publication number: 20160016937
    Abstract: The invention relates to novel substituted pyrimidine compounds of general formula (I) in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 21, 2016
    Inventors: Antonio NARDI, Florian JAKOB, Ingo KONETZKI, Tobias CRAAN, Christian HESSLINGER, Robin DOODEMAN
  • Novel 2,5-substituted pyrimidines
    Publication number: 20160016938
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 21, 2016
    Inventors: Antonio NARDI, Florian JAKOB, Ingo KONETZKI, Tobias CRAAN, Christian HESSLINGER
  • 4-AMINO SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS AS PDE4 INHIBITORS
    Publication number: 20150353507
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: August 4, 2015
    Publication date: December 10, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Ingo KONETZKI, Florian JAKOB, Tobias CRAAN, Christian HESSLINGER
  • NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS
    Publication number: 20150344496
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: August 4, 2015
    Publication date: December 3, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Ingo KONETZKI, Florian JAKOB, Tobias CRAAN, Christian HESSLINGER, Paul RATCLIFFE, Jason J. SHIERS