Patents by Inventor Florian Karl

Florian Karl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240369061
    Abstract: A rotary piston compressor for compressing gas, in particular carbon dioxide, in which a side wall face of a housing side wall and a respective planar sealing face of a respective housing cover enclose a working chamber and a rotary piston is rotatably mounted in the working chamber on an eccentric. A respective planar-seal receiving channel is formed in the piston bases of the rotary piston and a planar seal is arranged in each of the planar-seal receiving channels. To press the seal surface of the respective planar seal against the respective planar sealing face, lateral-surface openings in the piston lateral surface of the rotary piston have a pressure-transmitting connection to the respective planar-seal receiving channel via pressure leadthrough lines, formed inside the rotary piston and each open into the respective planar-seal receiving channel on a side of the respective planar seal facing away from the seal surface.
    Type: Application
    Filed: July 14, 2021
    Publication date: November 7, 2024
    Inventor: Florian Karl AUSSERER
  • Patent number: 11786498
    Abstract: The invention relates to polymorphic forms of the calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester. The calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester is useful in the treatment of various conditions and disorders responsive to the inhibition of neutral endopeptidases.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: October 17, 2023
    Assignee: Novartis AG
    Inventors: David Hook, Bin Hu, Florian Karl Kleinbeck, Ulrich Meier, Sibylle Mueller, Jean-Paul Mutz, Jan Schlomach, Paul Allen Sutton, Liladhar Murlidhar Waykole, Bernhard Wietfeld
  • Patent number: 11434192
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: September 6, 2022
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Benjamin Martin, Gerhard Penn, Francesco Venturoni, Thierry Schlama, Thomas Ruch, Thomas Allmendinger, Bernhard Wietfeld, Paolo Filipponi
  • Patent number: 11008052
    Abstract: An air guiding device for a motor vehicle includes a rear wing, a wing supporting device configured to secure the rear wing and to forward forces which act on the rear wing, and connecting components configured to connect the rear wing and the wing supporting device to one another. A first of the connecting components is configured as a trough-shaped receiving device on the rear wing and/or the wing supporting device. A second of the connecting components which interacts with the first connecting component is configured as a hammer component on the other of the rear wing and/or the wing supporting device. The hammer component has a hammer handle and a hammer head which is connected to the hammer handle, extends transversely with respect thereto, and is received in the trough-shaped receiving device.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: May 18, 2021
    Assignee: Dr. Ing. h.c. F. Porsche Aktiengesellschaft
    Inventors: Andreas Kieschke, Riccardo Bauer, Tobias Posch, Florian Karl, Simon Fischer, Andreas Wallmann
  • Patent number: 10851059
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: December 1, 2020
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Ives Mafli, Benjamin Martin, Gerhard Penn, Gottfried Sedelmeier, Joerg Sedelmeier, Francesco Venturoni
  • Patent number: 10774036
    Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: September 15, 2020
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Tobias Kapferer, Hongyong Kim, Jie Ku, Kurt Laumen, Yunzhong Li, Wei Peng, Thomas Ruch, Thierry Schlama, Yao Yang
  • Publication number: 20190359554
    Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone.
    Type: Application
    Filed: December 20, 2017
    Publication date: November 28, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Tobias KAPFERER, Hongyong KIM, Jie KU, Kurt LAUMEN, Yunzhong LI, Wei PENG, Thomas RUCH, Thierry SCHLAMA, Yao YANG
  • Publication number: 20190308927
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Application
    Filed: June 25, 2019
    Publication date: October 10, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Benjamin MARTIN, Gerhard PENN, Francesco VENTURONI, Thierry SCHLAMA, Thomas RUCH, Thomas ALLMENDINGER, Bernhard WIETFELD, Paolo FILIPPONI
  • Publication number: 20190256454
    Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone.
    Type: Application
    Filed: June 30, 2017
    Publication date: August 22, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Tobias KAPFERER
  • Publication number: 20190248431
    Abstract: An air guiding device for a motor vehicle includes a rear wing, a wing supporting device configured to secure the rear wing and to forward forces which act on the rear wing, and connecting components configured to connect the rear wing and the wing supporting device to one another. A first of the connecting components is configured as a trough-shaped receiving device on the rear wing and/or the wing supporting device. A second of the connecting components which interacts with the first connecting component is configured as a hammer component on the other of the rear wing and/or the wing supporting device. The hammer component has a hammer handle and a hammer head which is connected to the hammer handle, extends transversely with respect thereto, and is received in the trough-shaped receiving device.
    Type: Application
    Filed: February 8, 2019
    Publication date: August 15, 2019
    Inventors: Andreas Kieschke, Riccardo Bauer, Tobias Posch, Florian Karl, Simon Fischer, Andreas Wallmann
  • Patent number: 10377697
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: August 13, 2019
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Benjamin Martin, Gerhard Penn, Francesco Venturoni, Thierry Schlama, Thomas Ruch, Thomas Allmendinger, Bernhard Wietfeld, Paolo Filipponi
  • Publication number: 20190202785
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.
    Type: Application
    Filed: August 16, 2017
    Publication date: July 4, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Ives MAFLI, Benjamin MARTIN, Gerhard PENN, Gottfried SEDELMEIER, Joerg SEDELMEIER, Francesco VENTURONI
  • Publication number: 20180354889
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Application
    Filed: December 8, 2016
    Publication date: December 13, 2018
    Inventors: Florian Karl KLEINBECK-RINIKER, Benjamin MARTIN, Gerhard PENN, Francesco VENTURONI, Thierry SCHLAMA, Thomas RUCH, Thomas ALLMENDINGER, Bernhard WIETFELD, Paolo FILIPPONI
  • Patent number: 10059670
    Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: August 28, 2018
    Assignee: Novartis AG
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck-Riniker
  • Publication number: 20170355677
    Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.
    Type: Application
    Filed: August 23, 2017
    Publication date: December 14, 2017
    Applicant: NOVARTIS AG
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck-Riniker
  • Patent number: 9776966
    Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: October 3, 2017
    Assignee: Novartis AG
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck
  • Publication number: 20170240509
    Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.
    Type: Application
    Filed: April 6, 2017
    Publication date: August 24, 2017
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck
  • Patent number: 9650373
    Abstract: Provided herein are processes useful for the preparation of 2-carboxamide cycloamino urea derivatives of formula (X), and useful intermediates therefore, at internal temperatures such as less than about ?5° C. to about ?15° C. and using solvents such as tetrahydrofuran, bases such as amines, and the like.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: May 16, 2017
    Assignee: Novartis AG
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck
  • Publication number: 20130331579
    Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.
    Type: Application
    Filed: March 1, 2012
    Publication date: December 12, 2013
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck
  • Patent number: 6473884
    Abstract: A method and system for equivalence checking of logical circuits using iterative circuit reduction and satisfiability techniques provide improved performance in computer-based verification and design tools. By intertwining a structural satisfiability solver and binary decision diagram functional circuit reduction method, computer-based tools can make more efficient use of memory and decrease computation time required to equivalence check large logical networks. Using the circuit reduction technique back-to-back with the simulation technique, optimum local and global circuit reduction are simultaneously achieved. By iterating between the structural and functional techniques, and adjusting the size of sub-networks being analyzed within a larger network, sub-networks can be reduced or eliminated, decreasing the amount of memory required to represent the next larger inclusive network.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: October 29, 2002
    Assignee: International Business Machines Corporation
    Inventors: Malay Kumar Ganai, Geert Janssen, Florian Karl Krohm, Andreas Kuehlmann, Viresh Paruthi