Patents by Inventor Florian Karl Kleinbeck

Florian Karl Kleinbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sacubitril calcium salts
    Patent number: 11786498
    Abstract: The invention relates to polymorphic forms of the calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester. The calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester is useful in the treatment of various conditions and disorders responsive to the inhibition of neutral endopeptidases.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: October 17, 2023
    Assignee: Novartis AG
    Inventors: David Hook, Bin Hu, Florian Karl Kleinbeck, Ulrich Meier, Sibylle Mueller, Jean-Paul Mutz, Jan Schlomach, Paul Allen Sutton, Liladhar Murlidhar Waykole, Bernhard Wietfeld
  • Process and intermediates
    Patent number: 11434192
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: September 6, 2022
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Benjamin Martin, Gerhard Penn, Francesco Venturoni, Thierry Schlama, Thomas Ruch, Thomas Allmendinger, Bernhard Wietfeld, Paolo Filipponi
  • Processes and intermediates for NEP inhibitor synthesis
    Patent number: 10851059
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: December 1, 2020
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Ives Mafli, Benjamin Martin, Gerhard Penn, Gottfried Sedelmeier, Joerg Sedelmeier, Francesco Venturoni
  • Process for early sacubitril intermediates
    Patent number: 10774036
    Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: September 15, 2020
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Tobias Kapferer, Hongyong Kim, Jie Ku, Kurt Laumen, Yunzhong Li, Wei Peng, Thomas Ruch, Thierry Schlama, Yao Yang
  • NEW PROCESS FOR EARLY SACUBITRIL INTERMEDIATES
    Publication number: 20190359554
    Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone.
    Type: Application
    Filed: December 20, 2017
    Publication date: November 28, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Tobias KAPFERER, Hongyong KIM, Jie KU, Kurt LAUMEN, Yunzhong LI, Wei PENG, Thomas RUCH, Thierry SCHLAMA, Yao YANG
  • PROCESS AND INTERMEDIATES
    Publication number: 20190308927
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Application
    Filed: June 25, 2019
    Publication date: October 10, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Benjamin MARTIN, Gerhard PENN, Francesco VENTURONI, Thierry SCHLAMA, Thomas RUCH, Thomas ALLMENDINGER, Bernhard WIETFELD, Paolo FILIPPONI
  • NEW PROCESS FOR EARLY SACUBITRIL INTERMEDIATES
    Publication number: 20190256454
    Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone.
    Type: Application
    Filed: June 30, 2017
    Publication date: August 22, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Tobias KAPFERER
  • Process and intermediates
    Patent number: 10377697
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: August 13, 2019
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Benjamin Martin, Gerhard Penn, Francesco Venturoni, Thierry Schlama, Thomas Ruch, Thomas Allmendinger, Bernhard Wietfeld, Paolo Filipponi
  • NEW PROCESSES AND INTERMEDIATES FOR NEP INHIBITOR SYNTHESIS
    Publication number: 20190202785
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.
    Type: Application
    Filed: August 16, 2017
    Publication date: July 4, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Ives MAFLI, Benjamin MARTIN, Gerhard PENN, Gottfried SEDELMEIER, Joerg SEDELMEIER, Francesco VENTURONI
  • NEW PROCESS AND INTERMEDIATES
    Publication number: 20180354889
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Application
    Filed: December 8, 2016
    Publication date: December 13, 2018
    Inventors: Florian Karl KLEINBECK-RINIKER, Benjamin MARTIN, Gerhard PENN, Francesco VENTURONI, Thierry SCHLAMA, Thomas RUCH, Thomas ALLMENDINGER, Bernhard WIETFELD, Paolo FILIPPONI
  • Synthesis of 2-carboxamide cycloamino urea derivatives
    Patent number: 10059670
    Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: August 28, 2018
    Assignee: Novartis AG
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck-Riniker
  • SYNTHESIS OF 2-CARBOXAMIDE CYCLOAMINO UREA DERIVATIVES
    Publication number: 20170355677
    Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.
    Type: Application
    Filed: August 23, 2017
    Publication date: December 14, 2017
    Applicant: NOVARTIS AG
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck-Riniker
  • Synthesis of 2-carboxamide cycloamino urea derivatives
    Patent number: 9776966
    Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: October 3, 2017
    Assignee: Novartis AG
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck
  • Synthesis of 2-carboxamide cycloamino urea derivatives
    Publication number: 20170240509
    Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.
    Type: Application
    Filed: April 6, 2017
    Publication date: August 24, 2017
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck
  • Synthesis of 2-carboxamide cycloamino urea derivatives
    Patent number: 9650373
    Abstract: Provided herein are processes useful for the preparation of 2-carboxamide cycloamino urea derivatives of formula (X), and useful intermediates therefore, at internal temperatures such as less than about ?5° C. to about ?15° C. and using solvents such as tetrahydrofuran, bases such as amines, and the like.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: May 16, 2017
    Assignee: Novartis AG
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck
  • Synthesis of 2-carboxamide cycloamino urea derivatives
    Publication number: 20130331579
    Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.
    Type: Application
    Filed: March 1, 2012
    Publication date: December 12, 2013
    Inventors: Bernhard Erb, Isabelle Sylvie Gallou, Florian Karl Kleinbeck