Patents by Inventor Florian Kast

Florian Kast has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bispecific HER2 Ligands for Cancer Therapy
    Publication number: 20220135700
    Abstract: The invention relates to a bispecific HER2-targeting agent that includes (a) a first polypeptide ligand that binds to HER2 extracellular domain 1, (b) a second polypeptide ligand that binds to HER2 extracellular domain 4, and (c) a linker covalently attaching said first polypeptide ligand to said second polypeptide ligand.
    Type: Application
    Filed: January 17, 2022
    Publication date: May 5, 2022
    Applicant: UNIVERSITÄT ZÜRICH
    Inventors: Andreas Plückthun, Florian Kast, Martin Schwill, Annemarie Honegger, Rastislav Tamaskovic, Christian Jost
  • HER2-BINDING TETRAMERIC POLYPEPTIDES
    Publication number: 20210395396
    Abstract: The invention relates to a tetrameric polypeptide comprising a first polypeptide chain comprising a first VL antigen binding domain and a first CL constant domain, a second polypeptide chain comprising a first VH antigen binding domain, a first CH1 constant domain, a first CH2 constant domain and a first CH3 constant domain, a first ligand binding to a HER2 D4 epitope linked to the N-terminus of said first VL antigen binding domain or said first VH antigen binding domain by a first interdomain amino acid linker, a third polypeptide chain comprising a second VL antigen binding domain and a second CL constant domain, a fourth polypeptide chain comprising a second VH antigen binding domain, a second CH1 constant domain, a second CH2 constant domain and a second CH3 constant domain and a third ligand binding to a HER2 D4 epitope linked to the N-terminus of said second VL antigen binding domain or said second VH antigen binding domain by a second interdomain amino acid linker, wherein the VL antigen binding domain
    Type: Application
    Filed: October 8, 2019
    Publication date: December 23, 2021
    Applicant: UNIVERSITÄT ZÜRICH
    Inventors: Florian KAST, Martin SCHWILL, Annemarie HONEGGER, Jakob STÜBER, Rastislav TAMASKOVIC, Andreas PLÜCKTHUN
  • Bispecific HER2 Ligands for Cancer Therapy
    Publication number: 20190127481
    Abstract: The invention relates to a bispecific HER2-targeting agent that includes (a) a first polypeptide ligand that binds to HER2 extracellular domain 1, (b) a second polypeptide ligand that binds to HER2 extracellular domain 4, and (c) a linker covalently attaching said first polypeptide ligand to said second polypeptide ligand.
    Type: Application
    Filed: October 8, 2018
    Publication date: May 2, 2019
    Applicant: UNIVERSITÄT ZÜRICH
    Inventors: Andreas Plückthun, Florian Kast, Martin Schwill, Annemarie Honegger, Rastislav Tamaskovic, Christian Jost