Abstract: The invention relates to a turbocharger which contains a bearing device which is arranged between a compressor and a turbine and which is designed to support a shaft. This bearing device has a bearing housing, in which an oil-lubricated bearing for supporting the shaft is arranged. The shaft has a slinger element extending in the circumferential direction for centrifugally dispersing lubricating oil. The bearing housing has an oil drainage channel for discharging the lubricating oil from the bearing housing. The inner region of the bearing housing forms an oil delimitation chamber, which is sealed off by seals arranged between the shaft and the bearing housing. The oil delimitation chamber has a deflection means which is formed in such a way that, during operation of the turbocharger, lubricating oil that is centrifugally dispersed by the slinger element is deflected by the deflection means and is conducted in the opposite direction to the seals.

Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: An exhaust turbocharger including a modular bearing designed for bearing a shaft and arranged between a compressor and a turbine is provided herein. The bearing has a bearing housing having a receptacle chamber, wherein a bearing assembly module can be or is installed in the receptacle chamber and can be non-destructively removed. The receptacle chamber is sized such that either a bearing assembly module having a rolling bearing or a bearing assembly module having a slide bearing can be installed. The receptacle chamber has an interface, designed to contact the bearing flange of a bearing assembly module inserted into the receptacle chamber. The interface is designed to connect an oil gallery passing through the bearing housing to one or more oil galleries passing through a bearing flange of the bearing assembly module.

Abstract: A glass container includes a body region with a first end and a second end, the body region having an outer diameter (d1) and a glass thickness (s1), the body region being characterized by a longitudinal axis (Ltube) that passes through a center of the first and second end. When the glass container is standing on a support surface, h2 is the distance between the support surface up to the second end of the body region. The following condition is fulfilled: (A×X)/B=C. A is an axial load necessary to break the glass container to obtain fragments, X is a normalized area in cm2 defined as h2×d1×?+d12/4×?, B is a number of fragments of the glass container, and C is a fracture ratio. C is 40 N×cm2 or more and B is 30 or more.

Abstract: A method for producing a container includes identifying a location at a body, with the body at this location having a stress parameter which has a value less than or equal to a threshold value. The identifying includes deriving the threshold value from a simulation result of a simulation based on a finite element method of the stress parameter for a surface area and/or a volume area of the body with or without a marking element present, the identifying also includes obtaining a mean value by the simulation for the stress parameter for at least a part of at least one of the surface area or the volume area of the body. The threshold value is a sum of the mean value and 1000 % or less of an absolute value of the mean value. A marking element is provided which allows identification of the container at the identified location.

Abstract: A glass container is provided having a glass tube with a first end and a second end and a glass bottom closing the second end. The glass tube has a longitudinal axis and has, in a direction from the first to the second end, a top region, a junction region, a neck region, a shoulder region, and a body region. The top region is at the first end and has an outer diameter (dt), the neck region has an outer diameter (dn) with dn<dt, the body region extends to the second end and has an outer diameter (db) with db>dt, and the glass tube in the body region has a thickness (lb). The outer contour in a transition area between the top and neck regions is defined by a radius of curvature. The glass containers have a neck squeeze test load of at least 1100 N.

Abstract: A glass container is provided having a glass tube with a first end and a second end and a glass bottom closing the second end. The glass tube has a longitudinal axis and has, in a direction from the first to the second end, a top region, a junction region, a neck region, a shoulder region, and a body region. The top region is at the first end and has an outer diameter (dt), the neck region has an outer diameter (dn) with dn<dt, the body region extends to the second end and has an outer diameter (db) with db>dt, and the glass tube in the body region has a thickness (lb). The outer contour in a transition area between the top and neck regions is defined by a radius of curvature. The glass containers have a neck squeeze test load of at least 1100 N.

Abstract: A glass container for packaging a pharmaceutical composition including a glass tube with a first end and a second end, the glass tube having a wall thickness dw and an outer diameter dc, a glass bottom with an outer area, the glass bottom closes the glass tube at the first end, and a curved glass heel extending from the outer area of the glass bottom to the first end of the glass tube. The curved glass heel is defined by an outer radius ro, an inner radius ri, and a thickness of the glass dh in the curved glass heel and: [100×(dh3×ri)/(dw ×dc2)]+(4.4 mm2/dc)>0.55 mm.

Abstract: The invention relates to an exhaust turbocharger, which contains a modular bearing, which is designed for bearing a shaft and is arranged between a compressor and a turbine, wherein the bearing has a bearing housing having a receptacle chamber, wherein a bearing assembly module can be or is installed in the receptacle chamber and can be non-destructively removed, the receptacle chamber being sized such that optionally either a bearing assembly module having a rolling bearing or a bearing assembly module having a slide bearing can be installed, the receptacle chamber having an interface, which is designed to contact the bearing flange of a bearing assembly module inserted into the receptacle chamber, the interface being designed to connect an oil gallery passing through the bearing housing to one or more oil galleries passing through a bearing flange of the bearing assembly module.

Abstract: The invention relates to a turbocharger which contains a bearing device which is arranged between a compressor and a turbine and which is designed to support a shaft. This bearing device has a bearing housing, in which an oil-lubricated bearing for supporting the shaft is arranged. The shaft has a slinger element extending in the circumferential direction for centrifugally dispersing lubricating oil. The bearing housing has an oil drainage channel for discharging the lubricating oil from the bearing housing. The inner region of the bearing housing forms an oil delimitation chamber, which is sealed off by seals arranged between the shaft and the bearing housing. The oil delimitation chamber has a deflection means which is formed in such a way that, during operation of the turbocharger, lubricating oil that is centrifugally dispersed by the slinger element is deflected by the deflection means and is conducted in the opposite direction to the seals.

Abstract: A glass container for packaging a pharmaceutical composition including a glass tube with a first end and a second end, the glass tube having a wall thickness dw, a glass bottom having an outer area, and the glass bottom closes the glass tube at the first end. The glass container further including a curved glass heel extending from the outer area of the glass bottom to the first end of the glass tube. The curved glass heel is defined by an outer radius ro, an inner radius ri and a thickness of the glass dh in the curved glass heel, further wherein dh3/(ro×dw)>0.8 mm.

Abstract: A container for holding at least one pharmaceutical composition includes a body that includes a marking element at a location that allows identification of the container. A stress parameter of the body has a value less than or equal to a threshold value at the location. The threshold value is derived and/or derivable from a simulation result of a simulation based on a finite element method of the stress parameter for a surface area and/or a volume area of the body with or without the marking element present. A mean value is obtained or is obtainable by the simulation for the stress parameter for at least a part of the surface area and/or the volume area. The threshold value is the sum of the mean value and 1000% or less of an absolute value of the mean value.

Abstract: A glass container is provided having a glass tube with a first end and a second end and a glass bottom closing the second end. The glass tube has a longitudinal axis and has, in a direction from the first to the second end, a top region, a junction region, a neck region, a shoulder region, and a body region. The top region is at the first end and has an outer diameter (dt), the neck region has an outer diameter (dn) with dn<dt, the body region extends to the second end and has an outer diameter (db) with db>dt, and the glass tube in the body region has a thickness (lb). The outer contour in a transition area between the top and neck regions is defined by a radius of curvature. The glass containers have a neck squeeze test load of at least 1100 N.

Abstract: A glass container is provided having a glass tube with a first end and a second end and a glass bottom closing the second end. The glass tube has a longitudinal axis and has, in a direction from the first to the second end, a top region, a junction region, a neck region, a shoulder region, and a body region. The top region is at the first end and has an outer diameter (dt), the neck region has an outer diameter (dn) with dn<dt, the body region extends to the second end and has an outer diameter (db) with db>dt, and the glass tube in the body region has a thickness (lb). The outer contour in a transition area between the top and neck regions is defined by a radius of curvature. The glass containers have a neck squeeze test load of at least 1100 N.

Abstract: A container of glass and a method for chemically prestressing such a container of glass are provided. The container of glass includes a hollow body with an internal volume, a wall with an inside surface, which borders the internal volume of the hollow body, and an outside surface opposite the inside surface. The wall has, at least in a partial region, a zone with compressive stress formed bordering the outside surface, as a result of which the outside surface is compression-prestressed at least in a partial region. The inside surface of the wall opposite this partial region is free from compressive stresses and is under tensile stress.

Abstract: A glass container for packaging a pharmaceutical composition including a glass tube with a first end and a second end, the glass tube having a wall thickness dw and an outer diameter dc, a glass bottom with an outer area, the glass bottom closes the glass tube at the first end, and a curved glass heel extending from the outer area of the glass bottom to the first end of the glass tube. The curved glass heel is defined by an outer radius ro, an inner radius ri, and a thickness of the glass dh in the curved glass heel and wherein: [100×(dh3×ri)/(dw ×dc2)]+(4.4 mm2/dc)>0.55 mm.

Abstract: A glass container for packaging a pharmaceutical composition including a glass tube with a first end and a second end, the glass tube having a wall thickness dw, a glass bottom having an outer area, and the glass bottom closes the glass tube at the first end. The glass container further including a curved glass heel extending from the outer area of the glass bottom to the first end of the glass tube. The curved glass heel is defined by an outer radius ro, an inner radius ri and a thickness of the glass dh in the curved glass heel, further wherein dh3/(ro×dw)>0.8 mm.