Abstract: Provided herein are compounds of the formula: wherein the variables are defined herein. The present disclosure also provides pharmaceutical compositions comprising the compounds disclosed herein as well as methods of treatment using the compounds and/or compositions disclosed herein. Such compounds and compositions may be used, for example, for the inhibition of enolase enzymes.

Abstract: The present disclosure provides, in part, compounds of formula (I), wherein the variables are as defined herein, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat physiological disorders, such as proliferative disorders, mediated by TEA domain transcription factors.

Abstract: Provided is a method for the preparation of mono-amidated phosphates or phosphonates as well as mono-amidated phosphates and phosphonates prepared by such method.

Abstract: The present invention relates to a modified PriL gene, which encodes a modified protein which may comprise one or more modifications in the wild type protein sequence of SEQ ID NO: 1 or SEQ ID NO: 3 or in a protein sequence having at least 60% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 3. Alternatively, the wild type of the modified PriL gene encodes a protein according to SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 7, SEQ ID NO: 11, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 23, SEQ ID NO: 25, SEQ ID NO: 27, SEQ ID NO: 29, or SEQ ID NO: 31. The modification in the wild type protein sequence is an amino acid substitution.

Abstract: Provided herein are compounds of the formula: wherein the variables are defined herein. The present disclosure also provides pharmaceutical compositions comprising the compounds disclosed herein as well as methods of treatment using the compounds and/or compositions disclosed herein. Such compounds and compositions may be used, for example, for the inhibition of enolase enzymes.

Abstract: Sensor systems are described that are designed to be integrated with gloves for the human hand. An array of sensors detects forces associated with action of a hand in the glove, and associated circuitry generates corresponding control information that may be used to control a wide variety of processes and devices.

Abstract: Provided herein are compounds of the formula (I) wherein the variables R1, R2, R3, R4, X1, X2, Y1, and A1 are as defined herein. Such compounds may be used, for example, for the inhibition of enolase enzymes, including preferential inhibition of one isoenzyme of over one or more of the other isoenzymes. Methods of treatment using these compounds, as well as pharmaceutical compositions thereof, are also provided.

Abstract: Disclosed is a manufacturing method of a sensor by using 3D printing and 3D printer therefor. According to an embodiment of the present disclosure, a manufacturing method of a sensor by using 3D printing includes: forming a first shape having an inner space by using a non-conductive material, and simultaneously or sequentially, forming an electrode at a preset location in the inner space by using a conductive material; injecting conductive liquid into the inner space; and forming a second shape on the first shape by using the non-conductive material to seal the inner space of the first shape.

Abstract: Provided herein are compounds of the formula (I) wherein the variables R1, R2, R3, R4, X1, X2, Y1, and A1 are as defined herein. Such compounds may be used, for example, for the inhibition of enolase enzymes, including preferential inhibition of one isoenzyme of over one or more of the other isoenzymes. Methods of treatment using these compounds, as well as pharmaceutical compositions thereof, are also provided.

Abstract: Sensor systems are described that are designed to be integrated with gloves for the human hand. An array of sensors detects forces associated with action of a hand in the glove, and associated circuitry generates corresponding control information that may be used to control a wide variety of processes and devices.

Abstract: A tool (100) for manufacturing a component part from a flowable base material, wherein the tool (100) comprises a processing chamber (102) into which the flowable base material is introducible for manufacturing the component part, an acoustic sensor (104) configured for sensing an acoustic signal originating from the tool (100), particularly from the processing chamber (102), and being indicative of an interaction between the flowable base material and the tool (100), particularly the processing chamber (102), during the manufacturing, wherein the acoustic sensor (104) comprises a movable actuator (110), and a control unit (200) configured for controlling and/or documenting the manufacturing in the processing chamber (102) based on the sensed acoustic signal.

Abstract: A method and system for providing a consistent flow documents and data content across different organizational units of a company or agency where the documents and data come from different enterprise systems and data stores but are related to linked processes that share models for organizing the content in the business context and in a format that enables a user to relate the content to the process step or steps they are performing. The system includes a network service that enables a configuration utility to automatically discover the objects and metadata and provides for a mapping of selected fields of the metadata to regions displayed in the user interface view with provision for filtering the data by mapping selected fields to a user input form. Thereby, a business analyst can create solutions without writing and maintaining complex program logic for each combination of presentation environment, enterprise system and data store.

Abstract: A method and system for providing a consistent flow documents and data content across different organizational units of a company or agency where the documents and data come from different enterprise systems and data stores but are related to linked processes that share models for organizing the content in the business context and in a format that enables a user to relate the content to the process step or steps they are performing. The system includes a network service that enables a configuration utility to automatically discover the objects and metadata and provides for a mapping of selected fields of the metadata to regions displayed in the user interface view with provision for filtering the data by mapping selected fields to a user input form. Thereby, a business analyst can create solutions without writing and maintaining complex program logic for each combination of presentation environment, enterprise system and data store.

Abstract: A method and system for providing a consistent flow documents and data content across different organizational units of a company or agency where the documents and data come from different enterprise systems and data stores but are related to linked processes that share models for organizing the content in the business context and in a format that enables a user to relate the content to the process step or steps they are performing. The system includes a network service that enables a configuration utility to automatically discover the objects and metadata and provides for a mapping of selected fields of the metadata to regions displayed in the user interface view with provision for filtering the data by mapping selected fields to a user input form. Thereby, a business analyst can create solutions without writing and maintaining complex program logic for each combination of presentation environment, enterprise system and data store.