Patents by Inventor Florian Rubelt

Florian Rubelt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Whole transcriptome analysis in single cells
    Patent number: 12378596
    Abstract: The invention is a method of single cell transcriptome analysis. The method comprises detecting multiple transcripts in each individual cell of the plurality of cells by barcoding the transcripts with a cell-specific compound barcode formed using a DNA polymerase and a terminal transferase, optionally in a single enzyme such as a reverse transcriptase.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: August 5, 2025
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Martin Ranik, Florian Rubelt, Sedide Ozturk
  • IMMUNE PROFILING BY PRIMER EXTENSION TARGET ENRICHMENT
    Publication number: 20240401241
    Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.
    Type: Application
    Filed: June 12, 2024
    Publication date: December 5, 2024
    Inventors: Jan BERKA, Carolina DALLETT, Richard DANNEBAUM, Brian GODWIN, Seoyoung KIM, Jainee LEWIS, Khai LUONG, Sedide OZTURK, Joseph PLATZER, Florian RUBELT, Dilduz TELMAN
  • IMMUME CELL COUNTING BASED ON IMMUNE REPERTOIRE SEQUENCING
    Publication number: 20240287606
    Abstract: The disclosure includes methods and compositions for accurately detecting subject's immune cell repertoire based on sequencing genomic DNA of immune cells.
    Type: Application
    Filed: September 27, 2023
    Publication date: August 29, 2024
    Inventors: Jan Berka, Richard Dannebaum, Khai Luong, Florian Rubelt, Dilduz Telman
  • Immune profiling by primer extension target enrichment
    Patent number: 12043919
    Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.
    Type: Grant
    Filed: December 29, 2023
    Date of Patent: July 23, 2024
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Jan Berka, Carolina Dallett, Richard Dannebaum, Brian Godwin, Seoyoung Kim, Jainee Lewis, Khai Luong, Sedide Ozturk, Joseph Platzer, Florian Rubelt, Dilduz Telman
  • PRIMER EXTENSION TARGET ENRICHMENT OF IMMUNE RECEPTOR SEQUENCES IN ALLOIMMUNE DISORDERS OF PREGNANCY
    Publication number: 20240150834
    Abstract: Methods of monitoring the development of FNAIT using immune profiling is described.
    Type: Application
    Filed: November 3, 2022
    Publication date: May 9, 2024
    Inventors: Eva MARTIN, Florian RUBELT
  • IMMUNE PROFILING BY PRIMER EXTENSION TARGET ENRICHMENT
    Publication number: 20240125007
    Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.
    Type: Application
    Filed: December 29, 2023
    Publication date: April 18, 2024
    Inventors: Jan BERKA, Carolina DALLETT, Richard DANNEBAUM, Brian GODWIN, Seoyoung KIM, Jainee LEWIS, Khai LUONG, Sedide OZTURK, Joseph PLATZER, Florian RUBELT, Dilduz TELMAN
  • IMMUNE PROFILING BY PRIMER EXTENSION TARGET ENRICHMENT
    Publication number: 20240026570
    Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.
    Type: Application
    Filed: August 14, 2023
    Publication date: January 25, 2024
    Inventors: Jan BERKA, Carolina DALLETT, Richard DANNEBAUM, Brian GODWIN, Seoyoung KIM, Jainee LEWIS, Khai LUONG, Sedide OZTURK, Joseph PLATZER, Florian RUBELT, Dilduz TELMAN
  • WHOLE TRANSCRIPTOME ANALYSIS IN SINGLE CELLS
    Publication number: 20230416804
    Abstract: The invention is a method of single cell transcriptome analysis. The method comprises detecting multiple transcripts in each individual cell of the plurality of cells by barcoding the transcripts with a cell-specific compound barcode formed using a DNA polymerase and a terminal transferase, optionally in a single enzyme such as a reverse transcriptase.
    Type: Application
    Filed: May 26, 2023
    Publication date: December 28, 2023
    Inventors: Sedide Ozturk, Martin Ranik, Florian Rubelt
  • Immune profiling by primer extension target enrichment
    Patent number: 11773511
    Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: October 3, 2023
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Jan Berka, Carolina Dallett, Richard Dannebaum, Brian Godwin, Seoyoung Kim, Jainee Lewis, Khai Luong, Sedide Ozturk, Joseph Platzer, Florian Rubelt, Dilduz Telman
  • System for identification of antigens recognized by T cell receptors expressed on tumor infiltrating lymphocytes
    Patent number: 11603565
    Abstract: The invention is a method of identifying a cognate antigen for a T-cell receptor using neoantigens from a patient's tumor cells combined with the patient's T-cells and using cell sorting, genome sequencing, expressing TCR genes, presenting tumor neoantigens on MHC complex and uniquely barcoding the T-cells where TCR recognition occurs to tag all components of the TCR recognition complex.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: March 14, 2023
    Assignees: ROCHE SEQUENCING SOLUTIONS, INC., VENTANA MEDICAL SYSTEMS, INC.
    Inventors: Nelson R. Alexander, Aoune Barhoumi, Jan Berka, Rui Chen, Lisa L. Gallegos, Toumy Guettouche, Seoyoung Kim, Maeve E. O'Huallachain, Sedide Ozturk, Jigar Patel, Florian Rubelt, Stacey Stanislaw
  • WHOLE TRANSCRIPTOME ANALYSIS IN SINGLE CELLS
    Publication number: 20220177950
    Abstract: The invention is a method of single cell transcriptome analysis. The method comprises detecting multiple transcripts in each individual cell of the plurality of cells by barcoding the transcripts with a cell-specific compound barcode formed using a DNA polymerase and a terminal transferase, optionally in a single enzyme such as a reverse transcriptase.
    Type: Application
    Filed: December 3, 2020
    Publication date: June 9, 2022
    Inventors: Martin Ranik, Florian Rubelt, Sedide Ozturk
  • A SYSTEM FOR IDENTIFICATION OF ANTIGENS RECOGNIZED BY T CELL RECEPTORS EXPRESSED ON TUMOR INFILTRATING LYMPHOCYTES
    Publication number: 20210285049
    Abstract: The invention is a method of identifying a cognate antigen for a T-cell receptor using neoantigens from a patient's tumor cells combined with the patient's T-cells and using cell sorting, genome sequencing, expressing TCR genes, presenting tumor neoantigens on MHC complex and uniquely barcoding the T-cells where TCR recognition occurs to tag all components of the TCR recognition complex.
    Type: Application
    Filed: June 14, 2019
    Publication date: September 16, 2021
    Inventors: Nelson R. Alexander, Aoune Barhoumi, Jan Berka, Rui Chen, Lisa L. Gallegos, Toumy Guettouche, Seoyoung Kim, Maeve E. O'Huallachain, Sedide Ozturk, Jigar Patel, Florian Rubelt, Stacey Stanislaw
  • IMMUNE PROFILING BY PRIMER EXTENSION TARGET ENRICHMENT
    Publication number: 20210172015
    Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.
    Type: Application
    Filed: August 18, 2020
    Publication date: June 10, 2021
    Inventors: Jan Berka, Carolina Dallett, Richard Dannebaum, Brian Godwin, Seoyoung Kim, Jainee Lewis, Khai Luong, Sedide Ozturk, Joseph Platzer, Florian Rubelt, Dilduz Telman
  • METHODS OF IDENTIFYING MULTIPLE EPITOPES IN CELLS
    Publication number: 20200157603
    Abstract: The invention provides methods, compositions, kits and devices for the detection of target molecules. In some embodiments, the invention allows for multiplexed target molecule detection.
    Type: Application
    Filed: November 21, 2019
    Publication date: May 21, 2020
    Inventors: Maeve O'Huallachain, Carolina Dallett, Sedide Ozturk, Florian Rubelt, Sri Ramakrishna Paladugu, Razika Hussein, Garry P. Nolan