Abstract: The present invention generally relates to pH-dependent mutant interleukin-2 polypeptides that exhibit reduced IL-2 receptor binding at neutral pH and retained IL-2 receptor binding at reduced pH. In addition, the invention relates to immunoconjugates comprising said pH-dependent mutant IL-2 polypeptides, polynucleotide molecules encoding the pH-dependent mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the pH-dependent mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.

Abstract: A multiple-door switchgear cabinet includes a cabinet housing containing electrical equipment and being connectable to a power source. Doors attached to the cabinet housing provide access to the electrical equipment and include a first door and secondary doors. The first door, when closed, provides for electrical continuity through a main electrical power switch, and removes electrical continuity when open. A mechanical interlock controls the order in which the doors are closed. The mechanical interlock is mounted to the cabinet and is in contact with the doors when they are closed, the interlock being biased by a biasing device to bear against the first door when any of the other doors is opened. A locking bar is movably attached to the first door, and releasably attached to the secondary door. wherein attachment to the secondary door prevents both doors from inadvertent opening.

Abstract: A multiple-door switchgear cabinet includes a cabinet housing containing electrical equipment and being connectable to a power source. Doors attached to the cabinet housing provide access to the electrical equipment and include a first door and secondary doors. The first door, when closed, provides for electrical continuity through a main electrical power switch, and removes electrical continuity when open. A mechanical interlock controls the order in which the doors are closed. The mechanical interlock is mounted to the cabinet and is in contact with the doors when they are closed, the interlock being biased by a biasing device to bear against the first door when any of the other doors is opened. A locking bar is movably attached to the first door, and releasably attached to the secondary door. wherein attachment to the secondary door prevents both doors from inadvertent opening.