Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: Power tool, in particular a pipe press, including a drive, an output shaft, a threaded spindle drive and a linear actuator, wherein a torque generated by the drive is transmissible via the output shaft, and the threaded spindle drive connected to the output shaft, to the linear actuator. The power tool includes an eccentric transmission device for a torque adaptation between the drive and the threaded spindle drive, wherein the eccentric transmission device includes a drive eccentric, which is drivable by the drive, an eccentric gear, which is drivable by the drive eccentric, and a compensating coupling, which is drivable by the eccentric gear and which serves for transmitting torque from the eccentric gear to the output shaft.

Abstract: A power tool is provided comprising a drive, an output shaft, a threaded spindle drive and a linear actuator, wherein torque generated by the drive is transmissible via the output shaft, and the threaded spindle drive connected to the output shaft, to the linear actuator. the threaded spindle drive has an inner threaded spindle part with an external thread and an outer threaded spindle part with an internal thread, wherein the internal thread interacts with the external thread via at least one bearing roller, and the at least one bearing roller has at least one radially encircling channel by which the bearing roller engages in each case into the external thread and into the internal thread.

Abstract: A measuring apparatus ascertains measurement information relating to an input voltage. The measuring apparatus contains an operational amplifier having first and second inputs, and an output for providing the measurement information. The measuring apparatus further has a first input node for coupling to a first pole of the input voltage, and a first isolation resistor which connects the first input node to the first input of the operational amplifier. Moreover, the measuring apparatus contains a second input node for coupling to a second pole of the input voltage, and a second isolation resistor which connects the second input node to the second input of the operational amplifier. The measuring apparatus further has a feedback resistor which connects the output of the operational amplifier to the first input of the operational amplifier, and a reference resistor which connects the second input of the operational amplifier to a reference potential.

Abstract: A plate made of a rolled aluminum alloy and a method for producing said plate are disclosed. In order to achieve high strength values, it is proposed for the plate to have a partially recrystallized structure with a degree of recrystallization of less than 25%, wherein the non-recrystallized structure region of the structure is in the recovered state and has an average subgrain size of less than 10 ?m in the rolling direction.

Abstract: A tool for working a substrate, the tool having a stator and a working piston, which is intended to move relative to the stator along a working axis, also having a drive, which is intended to drive the working piston from a starting position along the working axis to the substrate, the drive comprising a first piston coil arranged on the working piston and a first stator coil arranged on the stator, and the first piston coil being intended to enter the first stator coil during a movement of the working piston relative to the stator along the working axis.

Abstract: A tool for working a substrate, having a stator and a working piston, which is intended to move relative to the stator along a working axis, and having a drive, which is intended to drive the working piston along the working axis from a starting position onto the substrate, the drive having a stator coil arranged on the stator and being intended to apply electrical current of a first current intensity I1 to the stator coil in order to generate a magnetic field which accelerates the working piston relative to the stator, the drive having a piston coil arranged on the working piston and being intended to apply electrical current of a second current intensity I2 to the piston coil in order to generate a magnetic field which accelerates the working piston relative to the stator, the second current intensity I2 being less than the first current intensity I1.

Abstract: A tool for working a substrate has a stator and a working piston, which is intended to move relative to the stator along a working axis and toward the substrate or to hit a fastening element, in order to drive the fastening element into the substrate, also having a drive, which is intended to drive the working piston along the working axis onto the substrate, the drive having a piston coil capacitor and a piston coil arranged on the working piston, the piston coil being electrically connectable to the piston coil capacitor in order during rapid discharge of the piston coil capacitor to have a current flowing through it and to generate a magnetic field which accelerates the working piston relative to the stator.

Abstract: A tool for working a substrate, the tool having a stator and a working piston, which is intended to move relative to the stator along a working axis, also having a drive, which is intended to drive the working piston from a starting position along the working axis to the substrate, the stator having a first electrical stator contact and the working piston having a first electrical piston contact, which slides on the first electrical stator contact and is arranged on a radially outer circumference of the working piston with respect to the working axis.

Abstract: A tool for working a substrate, the tool having a stator and a working piston, which is intended to move relative to the stator along a working axis and toward the substrate or to hit a fastening element in order to drive the fastening element into the substrate, also having a drive, which is intended to drive the working piston along the working axis onto the substrate, the drive having a capacitor and a piston coil arranged on the working piston, the piston coil being electrically connectable to the capacitor in order during rapid discharge of the capacitor to have a current flowing through it and to generate a magnetic field which accelerates the working piston relative to the stator, the drive having a diode which is arranged on the working piston and is electrically connected to the piston coil.

Abstract: A tool for working a substrate, the tool having a stator and a working piston, which is intended to move relative to the stator along a working axis, also having a drive, which is intended to drive the working piston from a starting position along the working axis to the substrate, the drive comprising a piston coil arranged on the working piston and a first stator coil arranged on the stator, the piston coil having a piston coil axis, which is oriented transversely, to the working axis.

Abstract: A tool for working a substrate has a stator and a working piston, which is intended to move relative to the stator along a working axis, also having a drive, which is intended to drive the working piston from a starting position along the working axis to the substrate, the drive comprising a piston coil arranged on the working piston and a first stator coil arranged on the stator, and the first piston coil being intended to enter the first stator coil during a movement of the working piston relative to the stator along the working axis.

Abstract: A method for operating a machine tool (1), in particular an angle grinder, comprising a tool (3) that can be rotatably brought into operative connection with a driven shaft (7), the machine tool (1) having a drive device (4) for actuating the driven shaft (7), a control device (8) for actuating the drive device (4) and at least one sensor device (9, 10) operatively connected to the control device (8). The sensor device (9, 10) is used to determine whether a device (3, 11) is operatively connected in a defined manner to a defined region of the machine tool (1), the control device (8) enabling operation of the drive device (4) only if the query result is positive. A machine tool (1) for carrying out a method of this kind is also described.

Abstract: A computer-implemented method for processing data associated with an electronic unit for a vehicle, for example, a motor vehicle. The method includes: providing a first application, for example, a measuring application executable on a computing device, which is designed to carry out and/or support a communication, for example, with respect to the data, between at least one further application executable on the computing device and at least one further unit, for example, provided externally of the unit.

Abstract: A battery includes a stacked arrangement of electrochemical cells. Each electrochemical cell is free of a cell housing and includes a bipolar plate having a substrate, a first active material layer formed on a first surface of the substrate, and a second active material layer formed on a second surface of the substrate. Each cell includes a solid electrolyte layer that encapsulates at least one of the active material layers, and an edge insulating device that is disposed between the peripheral edges of the substrates of each pair of adjacent cells. A support frame surrounds the cell stack and is configured to receive and support the outer peripheral edge of the edge insulating device of each cell.

Abstract: A battery includes a stacked arrangement of electrochemical cells. Each electrochemical cell is free of a cell housing and includes a bipolar plate having a substrate, a first active material layer formed on a first surface of the substrate, and a second active material layer formed on a second surface of the substrate. Each cell includes a solid electrolyte layer that encapsulates at least one of the active material layers, and electrically insulates a given cell of the cell stack from an adjacent cell of the cell stack including along a periphery of the cells.

Abstract: A battery includes a stacked arrangement of electrochemical cells. Each electrochemical cell is free of a cell housing and includes a bipolar plate having a substrate, a first active material layer formed on a first surface of the substrate, and a second active material layer formed on a second surface of the substrate. Each cell includes a solid electrolyte layer that encapsulates at least one of the active material layers, and an edge insulating device that is disposed between the peripheral edges of the substrates of each pair of adjacent cells. Within each cell, an elastic seal is provided between the edge insulating device and the first surface of one cell or the solid electrolyte layer of an adjacent cell.

Abstract: A battery includes a stacked arrangement of electrochemical cells. Each electrochemical cell is free of a cell housing and includes a bipolar plate having a substrate, a first active material layer formed on a first surface of the substrate, and a second active material layer formed on a second surface of the substrate. Each cell includes a solid electrolyte layer that encapsulates at least one of the active material layers, and an edge insulating device that is disposed between the peripheral edges of the substrates of each pair of adjacent cells. The edge insulating device physically contacts and is directly secured to one of the first surface of one cell and the solid electrolyte layer of an adjacent cell, and is movable relative to, the other of the first surface of the one cell and the solid electrolyte layer of the adjacent cell.

Abstract: A battery includes a stacked arrangement of electrochemical cells. Each electrochemical cell is free of a cell housing and includes a bipolar plate having a substrate, a first active material layer formed on a first surface of the substrate, and a second active material layer formed on a second surface of the substrate. Each cell includes a solid electrolyte layer that encapsulates at least one of the active material layers, and an edge insulating device that is disposed between the peripheral edges of the substrates of each pair of adjacent cells. Within each cell, the substrate includes a surface feature that is engaged with a corresponding feature of the edge insulating device in such a way as to locate the edge insulating device relative to the bipolar plate.

Abstract: A device for bombarding at least one substrate with a plasma with a first electrode and a second electrode that can be arranged opposite thereto, which electrodes are formed together producing the plasma between the electrodes wherein at least one of the electrodes is formed from at least two electrode units. In addition, this invention relates to a corresponding method.