Patents by Inventor Florian Schweinberger

Florian Schweinberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220246412
    Abstract: A method for checking a validity of a mass axis calibration of a mass spectrometer (MS) of an analyzer system, comprising obtaining a mass axis check sample spanning a predetermined m/z measurement range of the MS and automatically processing the sample, performing multiple full scan mode MS measurements of different types using the MS for the at least two mass axis points to obtain measurement data, wherein the different types include at least a first full scan MS measurement in a positive mode and a second measurement in a negative mode, or at least a first full scan measurement for a first mass filter and a second full scan measurement for a second mass filter; comparing the measurement data for each of the at least two mass axis points with respective reference data and determining if a condition is out of specification based on a result of the comparing steps.
    Type: Application
    Filed: March 4, 2022
    Publication date: August 4, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Florian Schweinberger
  • Publication number: 20220172940
    Abstract: A packaging for a needle-like component of a mass spectrometry (MS) system is provided. The packaging includes a receptacle configured for storing the needle-like component in a secured position inside the receptacle. The packaging further comprises an actuator configured to move the needle-like component from the secured position inside the receptacle to a mounting position in which the needle-like component projects out of the receptacle for mounting the needle-like component to the MS system.
    Type: Application
    Filed: November 2, 2021
    Publication date: June 2, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Florian Schweinberger
  • Publication number: 20220128531
    Abstract: A liquid chromatography-mass spectrometry (LC-MS) apparatus including an ionization source coupled to a mass spectrometer and a liquid chromatographic (LC) system coupled to the ionization source. The LC system comprises multiple fluidic streams alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream from the multiple fluidic streams when connected to the ionization source. The LC-MS apparatus further comprises a controller configured to carry out steps of monitoring an ionization current of the ionization source for the multiple fluidic streams and identifying differences in flow conditions between the multiple fluidic streams based on the monitored ionization current.
    Type: Application
    Filed: September 20, 2021
    Publication date: April 28, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Benjamin Tiemann, Stefan Quint, Florian Schweinberger
  • Patent number: 11287402
    Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: March 29, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Marian Roetzer, Florian Schweinberger, Benjamin Tiemann, Marius Wagner, Ralf Zimmermann
  • Patent number: 11249059
    Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: February 15, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Benjamin Tiemann, Florian Schweinberger, Martin Stingl
  • Publication number: 20210181166
    Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
    Type: Application
    Filed: December 7, 2020
    Publication date: June 17, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Marian Roetzer, Florian Schweinberger, Benjamin Tiemann, Marius Wagner, Ralf Zimmermann
  • Publication number: 20210063361
    Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.
    Type: Application
    Filed: August 14, 2020
    Publication date: March 4, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Benjamin Tiemann, Florian Schweinberger, Martin Stingl