Abstract: A method of using a polyarticulated system associated with a vision system for automatically picking up an article situated in a zone suitable for receiving at least one article, the polyarticulated system including at least one pick-up member suitable for taking hold of an article via at least one specific zone of the article. In accordance with the invention, the method includes at least the steps of: taking an image of the article-receiving zone; processing the information resulting from the 3D image and identifying all of the specific zones that are present on the articles to be taken hold of, and that are compatible with the pick-up member(s); locating the identified compatible specific zone(s); choosing one of the located compatible specific zones and automatically defining a pick path; and taking hold of the corresponding article along the defined path.