Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present invention pertains to a method for identifying a subject suffering from cancer as a responder or non-responder to fibroblast growth factor receptor 1 (FGFR1) inhibitor therapy. The method involves the determination of the presence or absence of a genetic alteration of the FGFR1 gene, wherein the genetic variation is a copy number variation caused by a Breakage-Fusion-Bridge-like (BFB-like) mechanism wherein the break is located within, or within close proximity of, the ORF of the FGFR1 gene. These breaks associate with FGFR inhibitor sensitivity, and intra-chromosomal tail-to-tail breaks in FGFR1 may work as a predictive therapeutic marker for an FGFR inhibitor therapy in cancer that can be used to stratify patients for FGFR-inhibitor therapy. Furthermore, provided are inhibitors of FGFR1 for use in the treatment of cancer, and a method for identifying a genetic biomarker associated with a disorder, such as cancer.

Abstract: An AI adversary red team configured to pentest email and/or network defenses implemented by a cyber threat defense system used to protect an organization and all its entities. AI model(s) trained with machine learning on contextual knowledge of the organization and configured to identify data points from the contextual knowledge including language-based data, email/network connectivity and behavior pattern data, and historic knowledgebase data. The trained AI models cooperate with an AI classifier in producing specific organization-based classifiers for the AI classifier. A phishing email generator generates automated phishing emails to pentest the defense systems, where the phishing email generator cooperates with the AI models to customize the automated phishing emails based on the identified data points of the organization and its entities. The customized phishing emails are then used to initiate one or more specific attacks on one or more specific users associated with the organization and its entities.

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

Abstract: The disclosure relates to a semiconductor die with a semiconductor body. The semiconductor die includes a vertical transistor device formed in a first area of the semiconductor body. The vertical transistor device includes a source region at a first side of the semiconductor body and a drain region at a second side of the semiconductor body. The semiconductor die further includes a first electrical isolation between the first area and a second area of the semiconductor body, and a diode in the second area of the semiconductor body. A cathode contact of the diode is electrically connected to the source region of the vertical transistor device.

Abstract: An AI adversary red team configured to pentest email and/or network defenses implemented by a cyber threat defense system used to protect an organization and all its entities. AI model(s) trained with machine learning on contextual knowledge of the organization and configured to identify data points from the contextual knowledge including language-based data, email/network connectivity and behavior pattern data, and historic knowledgebase data. The trained AI models cooperate with an AI classifier in producing specific organization-based classifiers for the AI classifier. A phishing email generator generates automated phishing emails to pentest the defense systems, where the phishing email generator cooperates with the AI models to customize the automated phishing emails based on the identified data points of the organization and its entities. The customized phishing emails are then used to initiate one or more specific attacks on one or more specific users associated with the organization and its entities.

Abstract: A load scanning apparatus for taking physical measurements from a load. The load scanning apparatus has a scanning robot including a plurality of sensors arranged in an array spanning substantially across at least one load dimension in a first direction. The array of sensors moves together in a second direction, in a scanning plane. The plurality of sensors are configured to take images of the load from the scanning plane, and are configured to capture distance information about the distance of said load from the scanning plane.

Abstract: A load scanning apparatus for taking physical measurements from a load. The load scanning apparatus has a scanning robot including a plurality of sensors arranged in an array spanning substantially across at least one load dimension in a first direction. The array of sensors moves together in a second direction, in a scanning plane. The plurality of sensors are configured to take images of the load from the scanning plane, and are configured to capture distance information about the distance of said load from the scanning plane.

Abstract: The node exposure score generator and the attack path modeling component are configured to cooperate to analyze the actual detected vulnerabilities that exist for that network node in the network, the importance of network nodes in the network compared to other network nodes in the network, and the key pathways within the network and the vulnerable network nodes in the network that a cyber-attack would use during the cyber-attack in order to provide an intelligent prioritization of remediation actions to remediate the actual detected vulnerabilities for each network node from the network protected by a cyber security appliance.

Abstract: At a switch terminal of a flyback converter in a discontinuous conduction mode in a power meter, an apparatus determines a resonant frequency of the flyback converter. The apparatus determines whether the resonant frequency satisfies a condition. Through a controller, the apparatus triggers an event responsive to determining that the resonant frequency satisfies the condition.

Abstract: An improved robot for packing produce such as fruit or other produce is provided. The robot includes a plurality of longitudinal carriage arms arranged in an array, and cantilevered off a support unit such that each longitudinal carriage arm is independently movable between an extended condition and retracted condition. Each arm includes a head connected to it that is independently movable in a vertical direction to pick up, hold and/or drop off an item of produce. Each longitudinal carriage arm is further independently movable in a lateral direction to alter the relative spacing between the plurality of heads such that the heads can move across lanes of the robot. The cantilevered arrangement of each carriage arm allows for compact set-out and other advantages.

Abstract: A load scanning apparatus for taking physical measurements from a load. The load scanning apparatus has a scanning robot including a plurality of sensors arranged in an array spanning substantially across at least one load dimension in a first direction. The array of sensors moves together in a second direction, in a scanning plane. The plurality of sensors are configured to take images of the load from the scanning plane, and are configured to capture distance information about the distance of said load from the scanning plane.

Abstract: A produce packing robot is provided comprising a plurality of heads for picking up items of produce from a plurality of pick-up locations, and moving the items of produce and dropping them off at a plurality of drop-off locations. The plurality of heads move together in a first direction on a common rail. The robot may also comprise a range imaging camera and controller for sensing the location of the drop-off points dynamically.

Abstract: A real-time messaging platform and method are disclosed which suggests messages and accounts from the real-time messaging platform.

Abstract: Methods, systems, and computer-readable storage media for data migration in an upgrade procedure executed on a software system include actions of initiating the upgrade procedure, determining a first set of tables of a source database that include data to be converted before being first written to a target database, converting data of the first set of tables to provide first converted data, and writing the converted data to one or more tables in the target database.

Abstract: The present disclosure teaches solutions for patching content in database systems. In one example, a deployment package for an upgrade of a database system to a new system is received, and the content is deployed to a shared container. Shared objects are identified that are completely stored in the shared container, and partially-shared objects are identified where those objects have a shared portion in the shared container and a tenant portion in one or more tenant containers. First shared content is determined for the shared objects, while second shared content is determined for partially-shared objects. The first and second shared content is then deployed to the shared container. Local content is determined for the partially-shared objects and is deployed to each tenant container. Local content is then identified for local objects and is also deployed to each respective tenant container. Accordingly, both shared and tenant content is deployed.

Abstract: Systems and methods for managing a virtual avatar with migrational ability, and brokering information, are provided. The persistent avatar exists in a plurality of virtual environments and includes attributes generated by an attribute generator, an enabler for enabling virtual environments to access the stored attribute data, and a migrator for allowing the avatar to migrate from one virtual environment to another while the attributes of the persistent avatar remain substantially constant. The enabler utilizes at least one client based on protocol suite. Stored attribute data is modifiable by experiences in any virtual environment. User of the persistent avatar is notified when events occur in any virtual environment, or within real life, by monitoring for events with a monitor, assessing importance of the event with an assessor, and notifying the owner with an informer of the event if it exceeds a threshold of importance.

Abstract: A produce packing robot is provided comprising a plurality of heads for picking up items of produce from a plurality of pick-up locations, and moving the items of produce and dropping them off at a plurality of drop-off locations. The plurality of heads move together in a first direction on a common rail. The robot may also comprise a range imaging camera and controller for sensing the location of the drop-off points dynamically.

Abstract: The present disclosure involves systems, software, and computer implemented methods for patching content in database systems. One example method includes receiving a deployment package for an upgrade of a database system to a new version. Content is deployed to a shared container. Shared objects are identified that are completely stored in the shared container. First shared content is determined for shared objects. Partially-shared objects are identified that have a shared portion in the shared container and a tenant portion in one or more tenant containers. Second shared content is determined for partially-shared objects. The first shared and second shared content are deployed to the shared container. Local content is determined for the partially-shared objects and deployed to each tenant container. Local objects that have no data in the shared container are identified. Local content is identified for the local objects and deployed to each respective tenant container.