Abstract: The present invention relates to novel pharmaceutical formulations, preferably for inhalation, comprising polyethylene glycol (PEG)-based prodrugs of Adrenomedullin (PEG-ADM) and the use thereof for the treatment and/or prevention of acute lung injury/acute respiratory distress syndrome (ALI/ARDS).

Abstract: The present invention relates to novel liquid pharmaceutical formulations, preferably for inhalation, comprising polyethylene glycol (PEG)-based prodrugs of Adrenomedullin (PEG-ADM) and the use thereof for the treatment and/or prevention of acute lung injury/acute respiratory distress syndrome (ALI/ARDS).

Abstract: The disclosure relates to a method for joining metal sheets resting on one another with a variable total thickness by a clinching device comprising at least one punch and a die arranged coaxially to the punch. The punch is controllable by an electronic control unit and movable in an axial direction relative to the die. The metal sheets are arranged in a plane between the punch and the die, and the penetration depth necessary for joining the metal sheets is adjustable. Before joining the metal sheets, the current total thickness is determined with the aid of the control unit and the penetration depth is set depending on the total thickness. The method includes: storing a number of different total thicknesses or total thickness ranges in the control unit, assigning a penetration depth to a total thickness or to a total thickness range, and calibrating the clinching device.

Abstract: A female die for a joining tool having an anvil and a shoulder which coaxially surrounds the anvil and which is configured on a main body of the anvil or by an end of a bush, and a sleeve which surrounds the main body or the bush, respectively, and which across the circumference thereof has radial slots penetrating the wall of said sleeve, in each case one sliding piece being guided in said slots so as to be movable in the radial direction (R), said sliding piece in the axial direction (A) being supported at least on the shoulder, is distinguished in that the wall of the sleeve on that end that surrounds the shoulder in the region between the slots has regions which widen in a radially inward manner and which extend in each case between two neighboring sliding pieces and in the radial direction (R) at least in part protrude beyond the shoulder.

Abstract: A tool carrier for a clinching installation, having a housing having a longitudinal axis (L), in which housing a downholder which is impinged by a first compression spring, an outer die which is impinged by a second compression spring, and an inner die which is rigidly connected to the housing are disposed coaxially within one another so as to be routed out of the housing) by way of the free ends of said downholder and dies, is distinguished in that the first compression spring is disposed so as to be coaxial within the second compression spring.

Abstract: The disclosure relates to a method for joining metal sheets resting on one another with a variable total thickness by a clinching device comprising at least one punch and a die arranged coaxially to the punch. The punch is controllable by an electronic control unit and movable in an axial direction relative to the die. The metal sheets are arranged in a plane between the punch and the die, and the penetration depth necessary for joining the metal sheets is adjustable. Before joining the metal sheets, the current total thickness is determined with the aid of the control unit and the penetration depth is set depending on the total thickness. The method includes: storing a number of different total thicknesses or total thickness ranges in the control unit, assigning a penetration depth to a total thickness or to a total thickness range, and calibrating the clinching device.

Abstract: A tool carrier for a clinching installation, having a housing having a longitudinal axis (L), in which housing a downholder which is impinged by a first compression spring, an outer die which is impinged by a second compression spring, and an inner die which is rigidly connected to the housing are disposed coaxially within one another so as to be routed out of the housing) by way of the free ends of said downholder and dies, is distinguished in that the first compression spring is disposed so as to be coaxial within the second compression spring.

Abstract: A female die for a joining tool having an anvil and a shoulder which coaxially surrounds the anvil and which is configured on a main body of the anvil or by an end of a bush, and a sleeve which surrounds the main body or the bush, respectively, and which across the circumference thereof has radial slots penetrating the wall of said sleeve, in each case one sliding piece being guided in said slots so as to be movable in the radial direction (R), said sliding piece in the axial direction (A) being supported at least on the shoulder, is distinguished in that the wall of the sleeve on that end that surrounds the shoulder in the region between the slots has regions which widen in a radially inward manner and which extend in each case between two neighboring sliding pieces and in the radial direction (R) at least in part protrude beyond the shoulder.

Abstract: A die for a joining tool, in particular for clinching, with an anvil (4) forming the bottom (41) of a swage (50), and with a spring sleeve (3) which surrounds the anvil (4) and has a plurality of slits (32) extending in an axial direction (A), said slits (32) permitting a radial expansion of the spring sleeve (3), is characterized in that bushing (1) which is arranged between the anvil (4) and the spring sleeve (3) and which is provided, at its free end (17), with inserts (2) which surround the anvil (4) and are made of a harder material than the bushing (1).

Abstract: A die for a joining tool, in particular for clinching, with an anvil (4) forming the bottom (41) of a swage (50), and with a spring sleeve (3) which surrounds the anvil (4) and has a plurality of slits (32) extending in an axial direction (A), said slits (32) permitting a radial expansion of the spring sleeve (3) , is characterized in that bushing (1) which is arranged between the anvil (4) and the spring sleeve (3) and which is provided, at its free end (17), with inserts (2) which surround the anvil (4) and are made of a harder material than the bushing (1).

Abstract: The present invention relates to pharmaceutical compositions comprising granules containing at least one recombinantly produced purified microbial lipase, the use of said pharmaceutical compositions for the manufacture of a medicament for the prevention or treatment of certain diseases or disorders like pancreatic endocrine insufficiency, and a process for the manufacture of said pharmaceutical compositions.