Patents by Inventor FLORIANE PELON

FLORIANE PELON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEW SUBPOPULATIONS OF CANCER ASSOCIATED FIBROBLASTS AS PROGNOSIS MARKERS FOR IMMUNOTHERAPY TREATMENTS
    Publication number: 20200371105
    Abstract: The present invention provides an in vitro method for selecting a patient affected with a tumor for an immunotherapy treatment or for predicting the response of a subject affected with a tumor to an immunotherapy treatment, wherein the method comprises: (a) detecting DPP4+ CAFs (Cancer Associated Fibroblast), and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs in a cancer sample from said patient; (b) determining the level(s) of DPP4+ CAFs, and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs in said cancer sample, wherein the responsiveness of said patient to an immunotherapy treatment is inversely proportional to the level(s) of DPP4+ CAFs, and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs in the cancer sample; (c) optionally, selecting patients with low level(s) of DPP4+ CAFs, and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs as suitable for an immunotherapy treatment.
    Type: Application
    Filed: July 26, 2018
    Publication date: November 26, 2020
    Inventors: ANA COSTA, YANN KIEFFER, ANNE-MARIE GIVEL, FLORIANE PELON, ANNE VINCENT-SALOMON, FATIMA MECHTA-GRIGORIOU