Abstract: Collimators for two-dimensional scans of a radiation sources and methods of scanning are provided. One system includes a scan unit for scanning and collecting ionizing radiation emitted from a radiation emitting object is provided. The scan unit includes an array of at least one pixelated radiation detector having an imaging surface including a two-dimensional (2D) array of pixels. The scan unit also includes a collimator positioned between the radiation detector and the radiation emitting object, with the collimator including a 2D array of columns having openings and septa forming bores, wherein the columns are arranged in groups along rows of the 2D array of columns and the bores within one of the groups have a different aspect ratios than the bores in another one of the groups.

Abstract: An apparatus and method for providing a predefined x-ray field is presented. Briefly in accordance with one aspect of the present disclosure, the apparatus includes a cathode unit configured to emit electrons within a vacuum chamber. The apparatus further includes an anode unit configured to generate x-rays when the emitted electrons impinge on a target surface of the anode unit. Also, the apparatus includes a collimating unit comprising a primary set of blades disposed in the vacuum chamber at a first distance from the anode unit for collimating the generated x-rays to provide the predefined x-ray field at a detector.

Abstract: A system and method for collimation in diagnostic imaging systems is provided. One collimator includes a plurality of parallel hole segments and a plurality of collimator bores within each of the plurality of parallel hole segments. Additionally, all of the plurality of collimator bores in at least one of the plurality of parallel hole segments have a first pointing direction and all of the plurality of collimator bores in at least one other of the plurality of parallel hole segments have a second pointing direction, wherein the plurality of parallel hole segments are arranged in a fanbeam collimation configuration. Further, the first pointing direction is different than the second pointing direction.

Abstract: A motion correction system and method for motion correction for an x-ray tube is presented. One embodiment of the motion correction system includes a sensing unit coupled to an x-ray tube to determine a distance with which an impingement location of an electron beam generated by the x-ray tube deviates from a determined location due to motion of the x-ray tube. The motion correction system further includes a control unit coupled to the sensing unit to generate a control signal corresponding to the distance with which the impingement location of the electron beam deviates. Also, the motion correction system includes a deflection unit coupled to the control unit to steer the electron beam to the determined location based on the generated control signal.

Abstract: Embodiments of systems, methods and non-transitory computer readable media for imaging are presented. Preliminary image data corresponding to a first FOV of a subject at a first resolution is acquired using an imaging system including one or more radiation sources and at least one hybrid detector, specifically using at least one section of the hybrid detector having the first resolution. The target ROI is identified using the preliminary image data. Further, the subject is positioned to align the target ROI along a designated axis. Additionally, parameters associated with the sources, the hybrid detector and/or an imaging system gantry are configured for acquiring target image data at a second resolution greater than the first resolution using at least one section of the hybrid detector having the second resolution. Further, one or more images corresponding to at least the target ROI are reconstructed using the target and/or the preliminary image data.

Abstract: A system and method for collimation in diagnostic imaging systems is provided. One collimation system includes a collimator for a radiation imaging detector having a plurality of adjustable segments and a plurality of collimator holes within each of the plurality of adjustable segments. The plurality of adjustable segments are configured to move independently of a detector to adjust a field of view of the collimator holes.

Abstract: Imaging detectors and methods of manufacturing are provided. One imaging detector includes a first detector layer within a detector module and a second detector layer within the detector module and spaced apart from the first detector layer, wherein the second detector layer has an opening therethrough. The imaging detector also includes a collimator mounted to the detector module, wherein the collimator is one of a single pinhole collimator or a multi-pinhole collimator. Additionally, the second detector layer is mounted within the detector module closer to an opening of the collimator than the first detector layer.

Abstract: A system and method for collimation in imaging systems are provided. One system includes a collimator a collimator body and at least one set of pinholes within the collimator body defining a cluster of pinholes, wherein bores defining the pinholes within the cluster are aligned to a point in substantially the same direction. Additionally, a spacing between bores is less than four times a diameter of a largest bore.

Abstract: Imaging detectors and methods of manufacturing are provided. One imaging detector includes a first detector layer within a detector module and a second detector layer within the detector module and spaced apart from the first detector layer, wherein the second detector layer has an opening therethrough. The imaging detector also includes a collimator mounted to the detector module, wherein the collimator is one of a single pinhole collimator or a multi-pinhole collimator. Additionally, the second detector layer is mounted within the detector module closer to an opening of the collimator than the first detector layer.

Abstract: Methods and systems for calibrating a nuclear medicine imaging system are provided. One method includes acquiring spatially determined non-uniform radiation flux information from a calibration scan of a calibration source using a gamma camera having an attached non-parallel-hole collimator. The method further includes determining a measured non-uniform count density profile from the acquired non-uniform radiation flux information. The method also includes creating a gamma camera uniformity correction map derived from (i) the measured non-uniform count density profile and (ii) a modeled or calculated non-uniform count density profile for calibrating the NM imaging system.

Abstract: A method and apparatus are provided for reducing motion related imaging artifacts. The method includes determining an internal motion for of two regions of the object, each region having a different level of motion, scanning the first region using a first scan protocol based on the motion, scanning a second region using a second different scan protocol based on the motion, and generating an image of the object based on the first and second regions.

Abstract: A system and method for collimation in diagnostic imaging systems is provided. One collimator includes a plurality of parallel hole segments and a plurality of collimator bores within each of the plurality of parallel hole segments. Additionally, all of the plurality of collimator bores in at least one of the plurality of parallel hole segments have a first pointing direction and all of the plurality of collimator bores in at least one other of the plurality of parallel hole segments have a second pointing direction, wherein the plurality of parallel hole segments are arranged in a fanbeam collimation configuration. Further, the first pointing direction is different than the second pointing direction.

Abstract: A method and apparatus for producing a PET image of a tissue using a PET scanner that includes scintillation crystals and detectors. A first crystal group including a first subset of crystals is formed, and a second crystal group including a second subset of the crystals is formed. The crystals in the first crystal group are different from crystals in the second crystal group A first beam striking one or more crystals of the first crystal group is converted to a first electrical signal, while a second beam striking one or more crystals of the second crystal group is converted to a second electrical signal, wherein the second beam is scattered from the first beam. The second electrical signal is corrected using a correction factor derived from at least one of a first and second timing relationships to compensate for energy in the second signal scattered from the first signal. An image of the tissue is created using the corrected second electrical signal.

Abstract: A system and method for collimation in diagnostic imaging systems is provided. One collimation system includes a collimator for a radiation imaging detector having a plurality of adjustable segments and a plurality of collimator holes within each of the plurality of adjustable segments. The plurality of adjustable segments are configured to move independently of a detector to adjust a field of view of the collimator holes.

Abstract: A method for laser patterning a sample is presented. The method includes coating at least one side of a substrate to form a sample, where coating the at least one side of the substrate forms an interface between the coating and the at least one side of the substrate. Further, the method includes configuring a scanning pattern for patterning the sample. In addition, the method includes determining settings for one or more laser beams of a laser based on the configured scanning pattern. Moreover, the method includes focusing the one or more laser beams of the laser at or near a surface of the substrate by selecting a focal point of the one or more laser beams near the surface of the substrate and setting a scribe depth near the surface of the substrate. The method also includes patterning the sample based on the configured scanning pattern using the one or more laser beams to generate one or more pixelated devices from the sample.

Abstract: Methods and systems for processing a set of images are described. In accordance with this disclosure, images are registered and an analysis is performed in view of one or more constraints (such as constraints based upon anatomical or physiological considerations). Weighting factors are determined based on the analysis. The weighting factors are used in subsequent processing of the registered (and/or unregistered) images and/or to formulate a visualization that conveys the degree of confidence in the motion estimation used in the registration process.

Abstract: A technique is provided for imaging based on localization of fluorescence in a medium. The technique includes illuminating the medium with an excitation light to excite fluorescence, scanning the medium at a plurality of locations via an ultrasonic beam, modulating a portion of the emitted light from the fluorescence via the ultrasonic beam at each of the plurality of locations, differentially detecting the modulated light at a boundary of the medium, and reconstructing an image from the detected signal.

Abstract: Methods and systems for calibrating a nuclear medicine imaging are provided. One method includes acquiring spatially determined non-uniform radiation flux information from a calibration scan of a calibration source using a gamma camera having an attached non-parallel-hole collimator. The method further includes determining a measured non-uniform count density profile from the acquired non-uniform radiation flux information. The method also includes creating a gamma camera uniformity correction map derived from (i) the measured non-uniform count density profile and (ii) a modeled or calculated non-uniform count density profile for calibrating the NM imaging system.

Abstract: A method for producing a PET image of a tissue using a PET scanner, the scanner comprising a plurality of scintillation crystals (70X/75X) and a plurality of detectors (71X/76X).

Abstract: The method calculates a scatter estimate for scatter correction of detection data from a subject in a positron emission tomographic scanner. The detection data represent the scattered events and unscattered events of annihilation photons emitted in the subject. The method uses the following steps: determine an estimate of the unscattered events; determine a simulation of the scattered events; determine a value of a scaling factor by fitting the sum of the estimate of the unscattered events and a product of the scaling factor and the simulation of the scattered events to the detection data; and determine the scatter estimate as the product of the scaling factor having said value and the simulation of the scattered events.