Patents by Inventor Florin V. Chirila

Florin V. Chirila has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peripheral diagnostic methods for screening Alzheimer's disease using beta amyloid and intercellular communication
    Patent number: 11099174
    Abstract: The present disclosure relates to a peripheral diagnostic method for screening Alzheimer's disease in patients based on quantitatively measured complexity of skin-sampled fibroblast networks.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: August 24, 2021
    Inventors: Florin V. Chirila, Tapan Kumar Khan, Daniel L. Alkon
  • PERIPHERAL DIAGNOSTIC METHODS FOR SCREENING ALZHEIMER'S DISEASE USING BETA AMYLOID AND INTERCELLULAR COMMUNICATION
    Publication number: 20190331668
    Abstract: The present disclosure relates to a peripheral diagnostic method for screening Alzheimer's disease in patients based on quantitatively measured complexity of skin-sampled fibroblast networks.
    Type: Application
    Filed: May 14, 2019
    Publication date: October 31, 2019
    Inventors: Florin V. Chirila, Tapan Kumar Khan, Daniel L. Alkon
  • Peripheral diagnostic methods for screening Alzheimer's disease using beta amyloid and intercellular communication
    Patent number: 10317396
    Abstract: The present disclosure relates to a peripheral diagnostic method for screening Alzheimer's disease in patients based on quantitatively measured complexity of skin-sampled fibroblast networks.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: June 11, 2019
    Assignee: West Virginia University
    Inventors: Florin V. Chirila, Tapan Kumar Khan, Daniel L. Alkon
  • DIAGNOSING MILD COGNITIVE IMPAIRMENT (MCI), PREDICTING ALZHEIMER'S DISEASE (AD) DEMENTIA ONSET, AND SCREENING AND MONITORING AGENTS FOR TREATING MCI OR PREVENTING DEMENTIA ONSET
    Publication number: 20190041404
    Abstract: Methods of detecting the signature of Alzheimer's disease before the clinical onset of the disease are disclosed, such as methods of diagnosing Mild Cognitive Impairment (MCI), monitoring the progress of MCI, and predicting the time to clinical onset of AD dementia. The methods use a Biomarker Severity Score, which corresponds to output signals of one or more biomarkers chosen from AD Index, Morphometric Imaging, and PKC Epsilon Biomarkers. Also disclosed are methods of screening for a compound useful for treating MCI or for preventing the clinical onset of AD dementia, as well as methods of evaluating or monitoring the therapeutic benefit of an agent for treating MCI or preventing the clinical onset of AD dementia.
    Type: Application
    Filed: February 22, 2017
    Publication date: February 7, 2019
    Inventors: Florin V. Chirila, Daniel L. Alkon
  • CONVERGENCE OF AGGREGATION RATE WITH VALIDATED PERIPHERAL DIAGNOSTIC FOR ALZHEIMER'S DISEASE
    Publication number: 20170023552
    Abstract: The present disclosure describes diagnostics for Alzheimer's disease based on the discovery of an increased aggregation rate with increasing cell density in cells from Alzheimer-disease patients versus controls. The aggregation rate was cross-validated with two more mature assays: AD-Index and Morphology diagnostic assays. Also disclosed is a simple-majority rule for diagnosing AD using at least three diagnostic assays, such as the Aggregation Rate, AD-Index, and Morphology assays.
    Type: Application
    Filed: January 2, 2015
    Publication date: January 26, 2017
    Inventors: Florin V. Chirila, Tapan K. Khan, Daniel L. Alkon
  • PHRIPHERAL DIAGNOSTIC METHODS FOR SCREENING ALZHEIMER'S DISEASE USING BETA AMYLOID AND INTERCELLULAR COMMUNICATION
    Publication number: 20140248648
    Abstract: The present disclosure relates to a peripheral diagnostic method for screening Alzheimer's disease in patients based on quantitatively measured complexity of skin-sampled fibroblast networks.
    Type: Application
    Filed: May 11, 2012
    Publication date: September 4, 2014
    Applicant: Blanchette Rockefeller Neurosciences Institute
    Inventors: Florin V. Chirila, Tapan Kumar Khan, Daniel L. Alkon