Abstract: A medical imaging system includes at least one medical imaging device providing image data of a subject and a processing system programmed to generate a plurality of training images having simulated medical conditions by blending a pathology region from a plurality of template source images to a plurality of target images. The processing system is further programmed to train a deep learning network model using the plurality of training images and input the image data of the subject to the deep learning network model. The processing system is further programmed to generate a medical image of the subject based on the output of the deep learning network model.