Patents by Inventor Floris Jacob Bikker
Floris Jacob Bikker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11944701Abstract: The invention relates to the use of sphingosine-based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine-based compounds. Compositions comprising sphingosine-based compounds are also provided.Type: GrantFiled: February 3, 2022Date of Patent: April 2, 2024Assignee: STICHTING VUInventors: Floris Jacob Bikker, Engelmundus Cornelis Ignatius Veerman, Marianne Valentijn-Benz, Willem Van 'T Hof
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Publication number: 20220151900Abstract: The invention relates to the use of sphingosine-based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine-based compounds. Compositions comprising sphingosine-based compounds are also provided.Type: ApplicationFiled: February 3, 2022Publication date: May 19, 2022Inventors: Floris Jacob BIKKER, Engelmundus Cornelis Ignatius VEERMAN, Marianne VALENTIJN-BENZ, Willem VAN 'T HOF
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Patent number: 11273113Abstract: The invention relates to the use of sphingosine based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine based compounds. Compositions comprising sphingosine based compounds are also provided.Type: GrantFiled: April 26, 2013Date of Patent: March 15, 2022Assignee: STICHTING VUInventors: Floris Jacob Bikker, Engelmundus Cornelis Ignatius Veerman, Marianne Valentijn-Benz, Willem Van 'T Hof
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Patent number: 11186619Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: GrantFiled: April 10, 2019Date of Patent: November 30, 2021Assignee: Universiteit Utrecht Holding B.V.Inventors: Floris Jacob Bikker, Albert van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree van der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Publication number: 20190233483Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: ApplicationFiled: April 10, 2019Publication date: August 1, 2019Applicant: Universiteit Utrecht Holding B.V.Inventors: Floris Jacob Bikker, Albert van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree van der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Patent number: 10301363Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: GrantFiled: March 26, 2015Date of Patent: May 28, 2019Assignee: Universiteit Utrecht Holding B.V.Inventors: Floris Jacob Bikker, Albert van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree van der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Publication number: 20150197547Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: ApplicationFiled: March 26, 2015Publication date: July 16, 2015Inventors: Floris Jacob Bikker, Albert van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree van der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Publication number: 20150147361Abstract: The invention relates to the use of sphingosine based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine based compounds. Compositions comprising sphingosine based compounds are also provided.Type: ApplicationFiled: April 26, 2013Publication date: May 28, 2015Applicant: Stichting VU-VUmcInventors: Floris Jacob Bikker, Engelmundus Cornelis Ignatius Veerman, Marianne Valentijn-Benz, Willem Van'T Hof
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Patent number: 9006174Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: GrantFiled: February 12, 2010Date of Patent: April 14, 2015Assignee: Universiteit Utrecht Holding B.V.Inventors: Floris Jacob Bikker, Albert Van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree Van Der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Patent number: 8852883Abstract: Substrates for detecting microorganisms are provided, wherein the substrate comprises a set of molecular markers linked, optionally with linker molecules or moieties, to a di-, or tripeptide consisting of amino acids X1 and X2, or X1, X2 and X3, in which one of them, for example, X1, is a D-amino acid and the others, for example, X2 and X3, may be any D- or L-amino acid. The substrate preferably is used for the detection of Bacillus anthracis. Also provided are substrates for detecting Pseudomonas aeruginosa, wherein the substrate comprises a set of molecular markers linked, optionally with linker molecules or moieties to a tri-, tetra-, or pentapeptide consisting of glycine amino acids. The invention further comprises methods for detecting microorganisms, specifically B. anthracis and P. aeruginosa, with the substrates of the invention and use of the substrate(s) in such a method.Type: GrantFiled: November 19, 2009Date of Patent: October 7, 2014Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNOInventors: Floris Jacob Bikker, Wendy Esmeralda Kaman-Van Zanten
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Publication number: 20120093844Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: ApplicationFiled: February 12, 2010Publication date: April 19, 2012Inventors: Floris Jacob Bikker, Albert Van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree Van Der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Publication number: 20120021454Abstract: The invention comprises a substrate for detection of micro-organisms, wherein said substrate comprises a set of molecular markers linked, optionally with linker molecules or moeieties, to a di-, or tripeptide consisting of amino acids X1 and X2, or X1, X2 and X3, in which one of them, for example X1, is a D-amino acid and the others, for example X2 and X3, may be any D- or L-amino acid. Said substrate preferably is used for the detection of Bacillus anthracis. Alternatively, the invention is directed to a substrate for detection of micro-organisms, more specifically P. aeruginosa, wherein said substrate comprises a set of molecular markers linked, optionally with linker molecules or moeities to a tri- tetra or pentapeptide consisting of glycine amino acids. The invention further comprises methods for detection of micro-organisms, specifically Bacillus anthracis and Pseudomonas aeruginosa, with the substrates of the invention and use of the substrate(s) in such a method.Type: ApplicationFiled: November 19, 2009Publication date: January 26, 2012Inventors: Floris Jacob Bikker, Wendy Esmeralda Kaman-Van Zanten
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Publication number: 20090312521Abstract: The invention concerns derivatives of drosocin which have an increased half-life in mammalian serum by substituting one or more of the amino acid residues of wild type drosocin with another amino acid or a peptidomimetic moiety capable of replacing said amino acid. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition.Type: ApplicationFiled: November 10, 2005Publication date: December 17, 2009Inventors: Petrus Albertus Venantia Van Hooft, Daniel Noort, Peter Christian De Visser, Herman Steven Overkleeft, Jacobus Hubertus Van Boom, Elisabeth M.H.C. van Boon-Husken, Floris Jacob Bikker