Patents by Inventor Floris Petrus Johannes Theodorus Rutjes
Floris Petrus Johannes Theodorus Rutjes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230102685Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: ApplicationFiled: June 13, 2022Publication date: March 30, 2023Applicant: Synaffix B.V.Inventors: Floris Louis Van Delft, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
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Patent number: 11358921Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: GrantFiled: March 19, 2019Date of Patent: June 14, 2022Assignee: SYNAFFIX B.V.Inventors: Floris Louis Van Delft, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
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Publication number: 20210169838Abstract: The present invention relates to the field of medicine, specifically the field of treatment and prevention of cardiovascular diseases.Type: ApplicationFiled: December 9, 2020Publication date: June 10, 2021Applicant: Stichting Katholieke UniversiteitInventors: Tom Johan Joseph Schirris, Tina Ritschel, Floris Petrus Johannes Theodorus Rutjes, Johannes Albertus Maria Smeitink, François Gérard Marie Russel
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Publication number: 20200048174Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: ApplicationFiled: March 19, 2019Publication date: February 13, 2020Applicant: SynAffix B.V.Inventors: Floris Louis VAN DELFT, Floris Petrus Johannes Theodorus RUTJES, Frederik Jan DOMMERHOLT
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Patent number: 10239807Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: GrantFiled: December 22, 2015Date of Patent: March 26, 2019Assignee: SynAffix B.V.Inventors: Floris Louis Van Delft, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
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Publication number: 20190038588Abstract: The present invention relates to the field of medicine, specifically the field of treatment and prevention of cardiovascular diseases.Type: ApplicationFiled: February 9, 2017Publication date: February 7, 2019Applicant: STICHTING KATHOLIEKE UNIVERSITEITInventors: Tom Johan Joseph Schirris, Tina Ritschel, Floris Petrus Johannes Theodorus Rutjes, Johannes Albertus Maria Smeitink, François Gérard Marie Russel
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Publication number: 20160214917Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: ApplicationFiled: December 22, 2015Publication date: July 28, 2016Applicant: SynAffix B.V.Inventors: Floris Louis VAN DELFT, Floris Petrus Johannes Theodorus RUTJES, Frederik Jan DOMMERHOLT
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Publication number: 20160107999Abstract: The invention relates to a substituted azadibenzocyclooctyne compound according to Formula (5): The invention also relates to a conjugate wherein a substituted azadibenzocyclooctyne according to the invention is conjugated to a label, and to the use of these conjugates for bioorthogonal labeling, imaging or modification of a target molecule, e.g. surface modification. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: ApplicationFiled: May 21, 2014Publication date: April 21, 2016Applicant: SynAffix B.V.Inventors: Marjoke Froukje DEBETS, Floris Petrus Johannes Theodorus RUTJES, Jan Cornelis Maria VAN HEST, Floris Louis VAN DELFT, Sander Sebastiaan VAN BERKEL
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Patent number: 9222940Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: GrantFiled: October 10, 2014Date of Patent: December 29, 2015Assignee: SynAffix B.V.Inventors: Floris Louis Van Delft, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
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Publication number: 20150125892Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: ApplicationFiled: October 10, 2014Publication date: May 7, 2015Applicant: SynAffix B.V.Inventors: Floris Louis VAN DELFT, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
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Patent number: 8859629Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: GrantFiled: April 26, 2011Date of Patent: October 14, 2014Assignee: Synaffix B.V.Inventors: Floris Louis van Delft, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
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Publication number: 20130137763Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: ApplicationFiled: April 26, 2011Publication date: May 30, 2013Inventors: Floris Louis van Delft, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
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Patent number: 8404647Abstract: The invention relates to PAD inhibitors that are suitable to be used as a medicament against an autoimmune disease such as RA.Type: GrantFiled: December 10, 2010Date of Patent: March 26, 2013Assignees: Chiralix B.V., Modiquest B.V., Academisch Ziekenhuis Leiden H.O.D.N. LumcInventors: Richard Hendrik Blaauw, Gerardus Jozef Maria Pruijn, Jozef Maria Hendrik Raats, Floris Petrus Johannes Theodorus Rutjes, Jan Wouter Drijfhout
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Publication number: 20110142868Abstract: The invention relates to PAD inhibitors that are suitable to be used as a medicament against an autoimmune disease such as RA.Type: ApplicationFiled: December 10, 2010Publication date: June 16, 2011Applicants: Chiralix B.V., ModiQuest V.V., Academisch Ziekenhuis Leiden h.o.d.n. LUMCInventors: Richard Hendrik Blaauw, Gerardus Jozef Maria Pruijn, Jozef Maria Hendrik Raats, Floris Petrus Johannes Theodorus Rutjes, Jan Wouter Drijfhout
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Publication number: 20090302190Abstract: A chip holder for holding a fluidic chip and for providing a fluid connection thereto has a guide adapted such that the fluidic chip can be slid into the chip holder in a guiding direction. The chip holder further has a fastener adapted to press a fluidic connection toward the fluidic chip, such that the fluidic chip is fixed within the chip holder. The guide and the fastener are adapted such that the guiding direction and the direction in which the fluidic connection is pressed exhibit an angle in the range between 45° and 135°, including 45° and 135°. A fluidic system has a chip holder and a fluidic chip inserted therein. A chip holder system has a chip holder and an extension module attached thereto such that the extension module is in contact with the fluidic chip, when the fluidic chip is inserted in the chip holder.Type: ApplicationFiled: October 25, 2006Publication date: December 10, 2009Applicants: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V., NIJMEGEN UNIVERSITYInventors: Hoc Khiem Trieu, Johann Slotkowski, Robert Klieber, Jan Cornelis Maria Van Hest, Kaspar Koch, Floris Petrus Johannes Theodorus Rutjes, Pieter Nieuwland, Peter Wiebke
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Publication number: 20090198084Abstract: The present invention relates to a process for the deprotection of protected amine compounds, wherein the protected amine compound is contacted with an electrophilic oxidating agent that is optionally formed in situ, said electrophilic oxidating agent being selected from the group of I2, Br2, Cl2 and compounds comprising a halogen atom having a formal oxidation state of 1+, 3+, 5+ or 7+, provided that the electrophilic oxidating agent is not iodobenzene diacetate. The process can be conveniently employed in the synthesis of 1,3-amino alcohols, ?-amino acids and heterocyclic compounds, in particular ?-amino acids.Type: ApplicationFiled: May 1, 2007Publication date: August 6, 2009Inventors: Paulus Lambertus Alsters, Jorge Merijn Mathieu Verkade, Peter Jan Leonard Mario Quaedflieg, Floris Petrus Johannes Theodorus Rutjes