Patents by Inventor Floyd E. Romesberg

Floyd E. Romesberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160168187
    Abstract: Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase-mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.
    Type: Application
    Filed: August 8, 2014
    Publication date: June 16, 2016
    Applicant: Synthorx, Inc.
    Inventors: Floyd E. ROMESBERG, Denis A. MALYSHEV, Lingjun LI, Thomas LAVERGNE, Zhengtao LI
  • Patent number: 9187524
    Abstract: Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product arylomycin in a range of pathogenic bacterial species has been found to depend upon single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases), wherein the presence of a proline residue confers arylomycin resistance. Arylomycin analogs are provided herein that can overcome that resistance and provide for a broader spectrum of antibiotic bioactivity than can natural product arylomycins such as arylomycin A2. Methods for determining if a bacterial strain is susceptible to narrow spectrum arylomycin antibiotics, or if a broad spectrum analog is required for treatment, is provided. Pharmaceutical compositions and methods of treatment of bacterial infections, and methods of synthesis of arylomycin analogs, are provided.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: November 17, 2015
    Assignee: The Scripps Research Institute
    Inventors: Floyd E. Romesberg, Peter A. Smith, Tucker C. Roberts
  • Publication number: 20150045286
    Abstract: Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product arylomycin in a range of pathogenic bacterial species has been found to depend upon single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases), wherein the presence of a proline residue confers arylomycin resistance. Arylomycin analogs are provided herein that can overcome that resistance and provide for a broader spectrum of antibiotic bioactivity than can natural product arylomycins such as arylomycin A2. Methods for determining if a bacterial strain is susceptible to narrow spectrum arylomycin antibiotics, or if a broad spectrum analog is required for treatment, is provided. Pharmaceutical compositions and methods of treatment of bacterial infections, and methods of synthesis of arylomycin analogs, are provided.
    Type: Application
    Filed: March 8, 2013
    Publication date: February 12, 2015
    Inventors: Floyd E. Romesberg, Peter A. Smith, Tucker C. Roberts
  • Publication number: 20130281360
    Abstract: Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product arylomycin in a range of pathogenic bacterial species has been found to depend upon single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases), wherein the presence of a proline residue confers arylomycin resistance. Arylomycin analogs are provided herein that can overcome that resistance and provide for a broader spectrum of antibiotic bioactivity than can natural product arylomycins such as arylomycin A2. Methods for determining if a bacterial strain is susceptible to narrow spectrum arylomycin antibiotics, or if a broad spectrum analog is required for treatment, is provided. Pharmaceutical compositions and methods of treatment of bacterial infections, and methods of synthesis of arylomycin analogs, are provided.
    Type: Application
    Filed: August 31, 2011
    Publication date: October 24, 2013
    Applicant: The Scipps Research Institute
    Inventors: Floyd E. Romesberg, Peter A. Smith, Tucker C. Roberts
  • Publication number: 20100130439
    Abstract: Modulators of error prone DNA polymerases are provided. Methods of inhibiting genomic mutation to inhibit the emergence of drug resistant target cells are also provided. Screening assays for identifying modulators of error prone DNA polymerases are provided.
    Type: Application
    Filed: April 25, 2008
    Publication date: May 27, 2010
    Inventors: Floyd E. Romesberg, Daniel A. Bachovchin
  • Patent number: 5942321
    Abstract: A headliner is a laminate of multiple layers. The layers include polyurethane foam, agricultural fibers, a decorative material, and a backing. The agricultural fiber is jute, sisal, or kenaf or mixtures thereof. The method of making the headliner laminate includes making the sheet of agricultural fibers incorporating a binder, saturating a foam layer with an adhesive, putting one sheet of agricultural fibers on each side of the foam layer, applying the decorative material and backing to one side each, and squeezing the layers together to distribute the adhesive to all the layers and laminate them.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: August 24, 1999
    Assignee: Findlay Industries, Inc.
    Inventors: Floyd E. Romesberg, J. Daniel Asbury, William J. Young
  • Patent number: 5582906
    Abstract: A headliner for mounting in the passenger compartment of a vehicle is formed from a plurality of layers of materials including foamed polyurethane, fiber glass and scrim. The layers are bonded together under heat which cures an incorporated thermosetting resin. The thermosetting resin freezes the assembled laminate conforming to the configuration of the lowermost mold. After setting of the resin the flexible laminate is trimmed to the desired shape at its periphery.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: December 10, 1996
    Assignee: Process Bonding, Inc.
    Inventors: Floyd E. Romesberg, David M. Steinke
  • Patent number: 5486256
    Abstract: A headliner for mounting in the passenger compartment of a vehicle is formed from a plurality of layers of materials including foamed polyurethane, fiber glass and scrim. The layers are bonded together under heat which cures an incorporated thermosetting resin. The thermosetting resin freezes the assembled laminate conforming to the configuration of the lowermost mold. After setting of the resin the flexible laminate is trimmed to the desired shape at its periphery.
    Type: Grant
    Filed: May 17, 1994
    Date of Patent: January 23, 1996
    Assignee: Process Bonding, Inc.
    Inventors: Floyd E. Romesberg, David M. Steinke
  • Patent number: 5051452
    Abstract: Novel polymeric blends comprising from 45-90% by weight of at least one vinylaromatic resinous material, 10-55% by weight of at least one vinylidene chloride polymer and, optionally but preferably, an effective amount of at least one blowing or expansion agent. The invention blends provide products having improved oxygen and water permeability, improved toughness, and improved flammability resistance.
    Type: Grant
    Filed: February 13, 1990
    Date of Patent: September 24, 1991
    Assignee: The Dow Chemical Company
    Inventor: Floyd E. Romesberg
  • Patent number: 4452374
    Abstract: The use of organic solvent-based coating compositions in the preparation of coated steel feedstock for use in the manufacture of draw-redraw food and beverage cans is eliminated by using as such can feedstock a laminated or extrusion coated steel sheet (e.g., such as electrolytic chrome/chrome oxide coated steel) having adhered to both major planar surfaces thereof an irradiated multilayered synthetic thermoplastic resin coating comprising:(1) an adhesive synthetic thermoplastic resin inner layer which is composed of at least a major proportion of a normally solid random copolymer of ethylene with from about 1 to about 30 weight percent, based upon the weight of such copolymer, of an ethylenically unsaturated carboxylic acid monomer and which is bonded directly to the surface of said steel sheet and(2) an outer layer of a synthetic thermoplastic polymer resin which has a crystalline melting point of at least about 250.degree. F. and which is adhered to said adhesive resin inner layer.
    Type: Grant
    Filed: April 2, 1981
    Date of Patent: June 5, 1984
    Assignee: The Dow Chemical Company
    Inventors: Martin K. Hitchcock, Craig W. Potter, Floyd E. Romesberg
  • Patent number: 4450977
    Abstract: The use of organic solvent-based coating compositions in the preparation of coated steel feedstock for use in the manufacture of retortable draw-redraw food and beverage cans is eliminated (A) by using as such can feedstock a laminated or extrusion coated steel sheet comprising a steel sheet material (e.g., such as electrolytic chrome/chrome oxide coated steel) having adhered to both major planar surfaces thereof a multilayered synthetic thermoplastic resin coating comprising (1) an adhesive synthetic thermoplastic resin inner layer (e.g., such as a layer of a normally solid random ethylene/acrylic acid copolymer) bonded directly to the surface of said steel sheet material and (2) an outer layer of a synthetic thermoplastic polymer resin which has a crystalline melting point of at least about 250.degree. F.
    Type: Grant
    Filed: April 2, 1981
    Date of Patent: May 29, 1984
    Assignee: The Dow Chemical Company
    Inventors: Lyle W. Colburn, Craig W. Potter, Floyd E. Romesberg
  • Patent number: 4252846
    Abstract: Heat seals of closely controlled peel strengths are obtained utilizing a heat seal layer comprising essentially a blend of an ethylene vinyl acetate copolymer and a high density ethylene homopolymer, wherein a sealing temperature is employed adapted to activate the copolymer to seal, but insufficient to activate the homopolymer. Film packages prepared according to the invention may embody an easy opening peel seal achieved by sealing in the above-defined temperature range, and much stronger seals in other areas of the package achieved using the same heat seal layer, but a higher sealing temperature generally nearer the crystalline melting point of the homopolymer constituent.
    Type: Grant
    Filed: September 22, 1975
    Date of Patent: February 24, 1981
    Assignee: The Dow Chemical Company
    Inventors: Floyd E. Romesberg, Frank V. Goff