Abstract: The present invention relates to a fully integrated systems and methods to offer end-to-end solution in designing, managing, recording, analyzing, mining and reporting of traditional as well as adaptive clinical trials with single transaction database. Particularly, the present invention relates to a system and method for clinical trial which will help pharmaceuticals/biotech/medical device companies and clinical research organizations (CROs) to manage various activities as per the business flow of a clinical trial, right from protocol design to submission of clinical study reports through their various functionalities/modules. Specifically, the present invention is suitable for adaptive clinical trials where the clinical plans are modified based on the results obtained in the single or multiple interim data analysis.