Patents by Inventor Focco Van den Akker

Focco Van den Akker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALDOKETO REDUCTASE INHIBITORS AND USES THEREOF
    Publication number: 20230219905
    Abstract: Aldoketo reductase (AKR) inhibitors having formulas I-III are used to treat disorders associated with NO/SNO deficiency.
    Type: Application
    Filed: December 6, 2022
    Publication date: July 13, 2023
    Inventors: Jonathan S. Stamler, William Greenlee, Focco van den Akker
  • Aldoketo reductase inhibitors and uses thereof
    Patent number: 11518748
    Abstract: Aldoketo reductase (AKR) inhibitors having formulas I-III are used to treat disorders associated with NO/SNO deficiency.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: December 6, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Jonathan S. Stamler, William Greenlee, Focco van den Akker
  • Dimerization interface of signal transducer and activator of transcription (STAT) proteins
    Publication number: 20040009571
    Abstract: The invention identifies an interface domain for interaction between two or more dimers of Signal Transducer and Activator of Transcription (STAT) proteins formed between amino acid residues Gln8 (Q8), Ile12 (I12), and Leu15 (L15) of &agr; helices 1 and 2, Met28 (M28) and Glu29 (E29) of &agr; helix 3 of a first STAT protein partner of the dimer, and Leu77 (L77) and Leu78 (L78) in &agr; helix 7 of a second STAT protein partner of the dimer. The interface domain is useful for designing and identifying compounds capable of enhancing or inhibiting binding between STAT protein dimers and/or DNA binding sites, and thus useful for identifying compounds able to modulate STAT protein dimer-dimer induction of gene expression.
    Type: Application
    Filed: June 25, 2002
    Publication date: January 15, 2004
    Inventors: John Kuriyan, James E. Darnell, Xiaomin Chen, Focco Van den Akker