Patents by Inventor Fode BENJAMIN

Fode BENJAMIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12247215
    Abstract: The present invention relates to a lysosomal protein composition comprising a plurality of lysosomal proteins that are potentially diversely glycosylated according to a glycosylation pattern, wherein said glycosylation pattern has at least 45% paucimannosidic N-glycans; a method of manufacturing the lysosomal protein composition in a bryophyte plant or cell, and medical and non-medical uses of the lysosomal protein composition. E.g. the lysosomal protein can be ?-Galactosidase for the treatment of Fabry Disease or ?-Glucoceramidase for the treatment of Gaucher's Disease. The unique glycosylation results in improved therapeutic efficacy—surprisingly even without mannose-6-phosphate that is common for CHO cell produced lysosomal proteins.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: March 11, 2025
    Assignee: ELEVA GMBH
    Inventors: Paulina Dabrowska-Schlepp, Fode Benjamin, Andreas Busch, Holger Niederkrüger, Andreas Schaaf
  • Publication number: 20220380791
    Abstract: The present invention relates to a lysosomal protein composition comprising a plurality of lysosomal proteins that are potentially diversely glycosylated according to a glycosylation pattern, wherein said glycosylation pattern has at least 45% paucimannosidic N-glycans; a method of manufacturing the lysosomal protein composition in a bryophyte plant or cell, and medical and non-medical uses of the lysosomal protein composition. E.g. the lysosomal protein can be ?-Galactosidase for the treatment of Fabry Disease or ?-Glucoceramidase for the treatment of Gaucher's Disease. The unique glycosylation results in improved therapeutic efficacy—surprisingly even without mannose-6-phosphate that is common for CHO cell produced lysosomal proteins.
    Type: Application
    Filed: April 25, 2022
    Publication date: December 1, 2022
    Applicant: eleva GmbH
    Inventors: Paulina DABROWSKA-SCHLEPP, Fode BENJAMIN, Andreas BUSCH, Holger NIEDERKRÜGER, Andreas SCHAAF
  • Patent number: 11401563
    Abstract: The present invention relates to a lysosomal protein composition comprising a plurality of lysosomal proteins that are potentially diversely glycosylated according to a glycosylation pattern, wherein said glycosylation pattern has at least 45% paucimannosidic N-glycans; a method of manufacturing the lysosomal protein composition in a bryophyte plant or cell, and medical and non-medical uses of the lysosomal protein composition. E.g. the lysosomal protein can be a-Galactosidase for the treatment of Fabry Disease or ?-Glucoceramidase for the treatment of Gaucher's Disease. The unique glycosylation results in improved therapeutic efficacy—surprisingly even without mannose-6-phosphate that is common for CHO cell produced lysosomal proteins.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: August 2, 2022
    Assignee: eleva GmbH
    Inventors: Paulina Dabrowska-Schlepp, Fode Benjamin, Andreas Busch, Holger Niederkrüger, Andreas Schaaf
  • Publication number: 20180016648
    Abstract: The present invention relates to a lysosomal protein composition comprising a plurality of lysosomal proteins that are potentially diversely glycosylated according to a glycosylation pattern, wherein said glycosylation pattern has at least 45% paucimannosidic N-glycans; a method of manufacturing the lysosomal protein composition in a bryophyte plant or cell, and medical and non-medical uses of the lysosomal protein composition. E.g. the lysosomal protein can be a-Galactosidase for the treatment of Fabry Disease or ?-Glucoceramidase for the treatment of Gaucher's Disease. The unique glycosylation results in improved therapeutic efficacy—surprisingly even without mannose-6-phosphate that is common for CHO cell produced lysosomal proteins.
    Type: Application
    Filed: March 17, 2016
    Publication date: January 18, 2018
    Applicant: GREENOVATION BIOTECH GMBH
    Inventors: Paulina DABROWSKA-SCHLEPP, Fode BENJAMIN, Andreas BUSCH, Holger NIEDERKRÜGER, Andreas SCHAAF