Patents by Inventor Folker Lieb

Folker Lieb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5482956
    Abstract: The present invention relates to the use of benzimidazoles of the formula (I) ##STR1## in which X.sup.1, X.sup.2, X.sub.3, X.sup.4, R.sup.3 and R.sup.5 are described herein and these compounds are agents for combatting parasitic protozoa, in particular coccidia.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: January 9, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Winfried Lunkenheimer, Bernd Baasner, Folker Lieb, Axel Haberkorn
  • Patent number: 5393729
    Abstract: The invention relates to 3-aryl-pyrone derivatives of the general formula (I) ##STR1## in which the substituents are as defined in the specification. The compounds are useful as pesticides, herbicides and fungicides.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: February 28, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reiner Fischer, Andreas Krebs, Folker Lieb, Michael Ruther, Jorg Stetter, Christoph Erdelen, Ulrike Wachendorff-Neumann, Klaus Lurssen, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 4988820
    Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl, represents a group of the formula --S(O).sub.m R.sup.3, in which R.sup.3 denotes alkyl or aryl, and m denotes one of the numbers 0, 1 or 2, represents a group of the formula ##STR2## in which R.sup.4 and R.sup.5 are identical or different and represent hydrogen, alkyl, aryl, aralkyl or acetyl, represents a group of the formula --OR.sup.6, in which R.sup.6 denotes hydrogen, alkyl, aryl, aralkyl, alkyl-SO.sub.2 --, aryl--SO.sub.2 --, aralkyl--SO.sub.2 -- or trifluoromethyl, or represents alkyl, alkenyl or cycloalkyl, each of which is optionally substituted by carboxyl, alkoxycarbonyl, halogen, hydroxyl, alkoxy, alkylthio or cyano, R.sup.
    Type: Grant
    Filed: July 20, 1990
    Date of Patent: January 29, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
  • Patent number: 4965258
    Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antoganize thromboxane A.sub.2.
    Type: Grant
    Filed: November 28, 1989
    Date of Patent: October 23, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
  • Patent number: 4904797
    Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A.sub.2.
    Type: Grant
    Filed: February 8, 1989
    Date of Patent: February 27, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
  • Patent number: 4886898
    Abstract: Certain intermediate aminomethyl-5,6,7,8-tetrahydronaphthyl-oxyacetic acid derivatives of the formula ##STR1## in which R.sup.2 is hydroxyl, alkoxy, phenoxy, benzoxy or NR.sup.4 R.sup.5, andR.sup.4 and R.sup.5 each independently is hydrogen or alkyl, or one of the radicals R.sup.4 or R.sup.5 is benzyl,which are useful in preparing the corresponding aryl-sulfonamides which in-turn have antithrombotic, antiatherosclerotic and antiischaemic properties.
    Type: Grant
    Filed: May 16, 1989
    Date of Patent: December 12, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Franz-Peter Hoever, Folker Lieb, Ulrich Rosentreter, Elisabeth Perzborn, Volker-Bernd Fiedler, Friedel Seuter
  • Patent number: 4882353
    Abstract: For inhibiting thombocyte aggregation, vasodilating and bronchodilating, the new chroman derivatives of the formula ##STR1## in which R.sup.1 stands for hydrogen, halogen, alkyl, hydroxyl, alkoxy, trifluoromethyl or cyano,R.sup.2 and R.sup.3 are identical or different and stand for hydrogen, alkyl, cycloalkyl or aryl,R.sup.4 stands for hydroxyl, alkoxy, aryloxy, aralkoxy or for a group of the formula --NR.sup.5 R.sup.6, whereR.sup.5 and R.sup.6 are identical or different and in each case denote hydrogen, alkyl, aryl or aralkyl,X denotes a direct bond or an oxygen or sulphur atom, NH or N-alkyl, andn denotes 0 or 1,and their physiologically tolerable salts.
    Type: Grant
    Filed: October 26, 1988
    Date of Patent: November 21, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Franz-Peter Hoever, Folker Lieb, Hermann Oediger, Ulrich Rosentreter, Horst Boshagen, Elisabeth Perzborn, Volker-Bernd Fiedler, Friedel Seuter
  • Patent number: 4868332
    Abstract: An aminomethyl-5,6,7,8-tetrahydronaphthyl-oxyacetic acid derivative of the formula ##STR1## in which R.sup.3 is aryl or substituted aryl,R.sup.2 is hydroxyl, alkoxy, phenoxy, benzoxy or NR.sup.4 R.sup.5, andR.sup.4 and R.sup.5 each independently is hydrogen or alkyl, or one of the radicals R.sup.4 or R.sup.5 is benzyl,and physiologically acceptable salts thereof with monovalent or divalent cations which have antithrombotic, antiatherosclerotic and antiischaemic activities.
    Type: Grant
    Filed: November 23, 1987
    Date of Patent: September 19, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Franz-Peter Hoever, Folker Lieb, Ulrich Rosentreter, Elisabeth Perzborn, Volker-Bernd Fiedler, Friedel Seuter
  • Patent number: 4853406
    Abstract: Thrombocyte aggregation-inhibiting polyhydrobenz[c,d]indolesulphonamide of the formula ##STR1## in which R.sup.1 is hydrogen, aryl or alkyl,R.sup.2 is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, hydroxyl, aralkoxy ora group of the formula ##STR2## R.sup.3 and R.sup.4 each independently is hydrogen, alkyl, aryl, aralkyl or acyl andX is cyano or carboxyl, and salts thereof. Intermediates therefor of the formula ##STR3## are also new.
    Type: Grant
    Filed: May 31, 1988
    Date of Patent: August 1, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Rosentreter, Horst Boshagen, Folker Lieb, Hermann Oediger, Ulrich Niewohner, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
  • Patent number: 4843091
    Abstract: An N-sulphonamidoethyl-indole of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, difluoromethoxy, aryl, arylthio, aralkyl, aralkoxy, aralkylthio, acyl or a group of the formula ##STR2## in which R.sup.5 and R.sup.6 are identical or different and denote hydrogen, alkyl, aryl, aralkyl or acyl, andR.sup.3 represents hydrogen, alkyl, aryl, pyridyl, thienyl or furyl, andR.sup.4 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, aryl, aryloxy, arylthio, aralkyl, aralkoxy, aralkylthio, acl or a group of the formula ##STR3## in which R.sup.7 and R.sup.8 are identical or different and denote hydrogen, alkyl, aryl, aralkyl or acyl,R.sup.5 represents hydrogen, ##STR4## or a pharmacologically acceptable salt of ##STR5## and R.sup.2 represents hydrogen, alkyl or aryl.The compounds were R.sup.
    Type: Grant
    Filed: June 5, 1987
    Date of Patent: June 27, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Rosentreter, Horst Boshagen, Folker Lieb, Hermann Oediger, Volker-Bernd Fiedler, Elisabeth Perzborn, Friedel Seuter
  • Patent number: 4827032
    Abstract: Cycloalkanol[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A.sub.2.
    Type: Grant
    Filed: June 29, 1988
    Date of Patent: May 2, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
  • Patent number: 4806551
    Abstract: New N-dihydroindolylethyl-sulphonamides are prepared from the corresponding N-indolylethyl-sulphonamides by oxidation or hydrogenation and are useful as active compounds in medicaments. These compounds exhibit a platelet aggregation-inhibiting and thromboxan A.sub.2 -antagonistic action.The N-dihydroindolylethyl-sulphonamides have the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl, or represents a group of the formula --S(O).sub.m R.sup.5,whereinR.sup.5 denotes alkyl or aryl andm denotes one of the numbers 0, 1 or 2, orR.sup.1 represents a group of the formula ##STR2## or R.sup.1 represents a group of the formula --OR.sup.8, orR.sup.1 represents optionally substituted alkyl, alkenyl or cycloalkyl,R.sup.2 represents aryl, which is optionally substituted by up to 5 substituents,R.sup.3 represents hydrogenor alkyl andR.sup.4 represents hydrogen, orR.sup.3 and R.sup.4 together bond a carbonyl oxygen.
    Type: Grant
    Filed: April 16, 1987
    Date of Patent: February 21, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Volker-Bernd Fiedler, Elisabeth Perzborn, Friedel Seuter
  • Patent number: 4774240
    Abstract: The invention relates to N-indolylethyl-sulphonic acid amides of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are defined in the specification and X is carboxyl, alkoxycarbonyl, cyano or carboxamido. These active compounds are useful in medicaments in combating thromboses, thromboembolisms, allergies or asthmatic disorders.
    Type: Grant
    Filed: April 14, 1986
    Date of Patent: September 27, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
  • Patent number: 4622339
    Abstract: Norbornane- and norbornene-carboxylic acid amides of the formula ##STR1## in which ##STR2## represents the part structure ##STR3## A represents a ##STR4## or --CH.sub.2 --CH.sub.2 -- group, R.sup.1 and R.sup.2 each independently is hydrogen or an alkyl radical with 1-6 carbon atoms,R.sup.3 is alkyl or alkenyl which has 1-8 carbon atoms and is optionally substituted by halogen or alkyl with 1 or 2 carbon atoms, cycloalkyl or cycloalkeny wtih 3 to 7 carbon atoms, an aromatic radical which has 6 or 10 carbon atoms and and is optionally substituted by halogen, by alkyl with 1 or 2 carbon atoms or by halogenoalkyl with 1 or 2 carbon atoms, or is a five-membered or six-membered heteroaromatic radical,R.sup.4 is hydrogen or a hydroxyl group,R.sup.5 and R.sup.6 each independently is hydrogen or alkyl with 1 to 4 carbon atoms, andn is a number from 2 to 6,and, if R.sup.1 is hydrogen, also physiologically acceptable salts thereof, perform as thromboxan antagonists.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: November 11, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Folker Lieb, Hermann Oediger, Hans-Joachim Kabbe, Ulrich Niewohner, Elisabeth Perzborn, Friedel Seuter
  • Patent number: 4447367
    Abstract: The invention relates to phosphonoformaldehyde of the formula ##STR1## Also included in the invention is a method for the manufacture of said phosphonoformaldehyde in which a dialkoxymethane phosphonic acid is warmed with water (then reacted with a base if a salt is desired.) Phosphonoformaldehyde is an intermediate for the manufacture of phosphonohydroxy acetic acid, which is an antiviral agent.
    Type: Grant
    Filed: April 22, 1982
    Date of Patent: May 8, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hermann Oediger, Folker Lieb, Hans Disselnkotter
  • Patent number: 4370280
    Abstract: The invention relates to phosphonodroxyacetonitrile and a process for its production which comprises reacting phosphono formaldehyde, in salt form, with hydrocyanic acid (then, if desired, converting the free phosphonohydroxyacetonitrile to salt thereof. The phosphonohydroxyacetonitrile is useful, for example, as an intermediate for the production of phosphonohydroxyacetic acid, an antiviral agent.
    Type: Grant
    Filed: October 5, 1981
    Date of Patent: January 25, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hermann Oediger, Folker Lieb, Hans Disselnkotter
  • Patent number: 4348332
    Abstract: The invention relates to phosphonoformaldehyde of the formula ##STR1## Also included in the invention is a method for the manufacture of said phosphonoformaldehyde in which a dialkoxymethane phosphonic acid is warmed with water (then reacted with a base if a salt is desired). Phosphonoformaldehyde is an intermediate for the manufactureof phosphonohydroxy acetic acid, which is an antiviral agent.
    Type: Grant
    Filed: October 5, 1981
    Date of Patent: September 7, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hermann Oediger, Folker Lieb, Hans Disselnkotter
  • Patent number: 4340599
    Abstract: The invention relates to phosphono-hydroxyacetic acid and salts thereof of Formula I as defined hereinabove, useful as antiviral agents, e.g. antiherpes agents. Also included in the invention are pharmaceutical compositions and medicaments containing said compounds of Formula I as the active ingredients as well as methods for the use of said compounds, compositions and medicaments.
    Type: Grant
    Filed: September 25, 1980
    Date of Patent: July 20, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Folker Lieb, Hermann Oediger, Gert Streible
  • Patent number: 4308263
    Abstract: The invention relates to phosphonoformic acid hydrazide compounds of the formula ##STR1## and salts thereof wherein R represents a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl radical. The compounds are useful as antiviral agents, particularly against herpes viruses.Also included in the invention are processes for preparing said phosphonoformic acid hydrazide compounds, compositions and medicaments containing said phosphonoformic acid hydrazide compounds and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: June 20, 1980
    Date of Patent: December 29, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hermann Oediger, Folker Lieb, Gert Streissle