Patents by Inventor Fontaine C. Bradley

Fontaine C. Bradley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5281578
    Abstract: Gallium(III) complexes of general formula I, ##STR1## in which X=O.sub.2 CR.sup.2, halogen, NO.sub.3 or -OA, R.sup.1 =H, alkyl, alkoxy, halogen, NO.sub.2 or amino, R.sup.2 =alkyl, alkoxy or aryl, each of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 =H or alkyl and n=0, 1 or 2, or when n=0 and R.sup.3 and R.sup.6 both=H, then R.sup.4 and R.sup.5 together may form tetramethylene, and A=an identical gallium complex moiety to that to which the oxygen atom is linked, are well absorbed orally, and are indicated as medicaments for hypercalcemia and for cancer chemotherapy.
    Type: Grant
    Filed: May 19, 1992
    Date of Patent: January 25, 1994
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Fontaine C. Bradley, Danielle T. Frost, Christen M. Giandomenico
  • Patent number: 5196412
    Abstract: The present invention relates to compounds of gallium (III) which can be given orally to achieve high serum levels of gallium (III) for the treatment of hypercalcemia of malignancy and related disorders of bone metabolism. Complexes of gallium (III) of the formula (I) ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.8 n-alkyl and R.sub.2 is H or C.sub.1 -C.sub.2 alkyl, or R.sub.1 and R.sub.2 together form tetra- or penta-methylene and wherein said complex is useful in increasing calcium content of bone tissue and decreasing bone resorption, are used in an amount sufficient to cause an increase in calcium content of said bone and to cause decreased bone resorption.
    Type: Grant
    Filed: March 6, 1991
    Date of Patent: March 23, 1993
    Assignee: Johnson Matthey, Inc.
    Inventors: Fontaine C. Bradley, Chris M. Giandomenico, Michael J. Abrams, Danielle T. Frost, Jean F. Vollano