Abstract: The present invention is generally directed to inhibitors of BCL-2 proteins useful in the treatment of diseases and disorders modulated by said enzyme and having the Formula (I):

Abstract: The presently disclosed subject matter relates to a system and method for customizing a cosmetic product. The system includes: an interface device, in electronic communication with a single batch cosmetic device. A container configured, to be imported into the single batch cosmetic device containing a base. The single batch cosmetic device configured to formulate a customized cosmetic product by mixing a cosmetic additive with the base inside the imported container using at least one mixing element. The container exported from the single batch cosmetic device containing the customized cosmetic.

Abstract: A system for cleaning bone that includes a base unit with a motor, a cleaning head with a cleaning element and a mill head with a mill element. Both the cleaning head and the mill head are designed to be coupled to the base unit. Both the cleaning element and mill element have features that facilitate their coupling to the motor. When the cleaning head is attached to the base unit, a motor in the base unit rotates the cleaning element to remove soft tissue from the bone so as to clean the bone. The mill element is placed on the base unit and the cleaned bone placed in the mill head. The actuation of the base unit motor results in the actuations of the mill element. The actuation of the mill element converts the cleaned bone into bone chips.

Abstract: A method, a device, and a non-transitory storage medium are described in which a mobile edge computing handover service is provided. The mobile edge computing handover service provides for the prospective provisioning of a target mobile edge computing network based on mobility information pertaining to an end device. The mobile edge computing handover service includes managing the provisioning of the application or service, content, and context information in relation to a source mobile edge computing network and the target mobile edge computing network.

Abstract: A waveguide display includes a display projector for emitting polychromatic image light, and a waveguide assembly for transmitting image light to an exit pupil. The waveguide assembly includes two or more waveguides disposed in a stack, each having an in-coupler aligned with the other in-couplers and an offset out-coupler aligned with the other out-couplers. The assembly is configured so that at least one color channel of the image light propagates to the exit pupil along at least two waveguides. A method for selecting the waveguides of the stack to suppress color channel splitting at the exit pupil is provided.

Abstract: Disclosed is an exoskeleton wearable device configured to push a condyle out from a glenoid structure of a skull made of two bellows shaped actuators each having an elliptical cross-section; an upper part configured to be fixed on a forehead of a patient and provide a base for the two bellows shaped actuators; and a lower part configured to be fixed on a mandible of the patient and substantially static to the mandible but moveable in a horizontal plane and a vertical plane with respect to the upper part.

Abstract: Implementations described herein relate to training and refining robotic control policies using imitation learning techniques. A robotic control policy can be initially trained based on human demonstrations of various robotic tasks. Further, the robotic control policy can be refined based on human interventions while a robot is performing a robotic task. In some implementations, the robotic control policy may determine whether the robot will fail in performance of the robotic task, and prompt a human to intervene in performance of the robotic task. In additional or alternative implementations, a representation of the sequence of actions can be visually rendered for presentation to the human can proactively intervene in performance of the robotic task.

Abstract: The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.

Abstract: Methods and systems for determining a ball shot attempt location on a ball court are disclosed. The method includes receiving an input video, where the input video includes the ball shot attempt and one or more players; receiving a declared ball shot attempt; determining a potential shooter by detecting a moving object flow in the input video; determining a potential shooter image region in the image plane by analyzing an overlapping image area of the ball trajectory and the potential shooter; determining a shooter foot-on-court time; determining a most probable pair of shooter legs in the potential shooter image region; determining a shooter foot location based on the most probable pair of shooter legs; and determining a ball shot attempt location on the ball court by applying a camera projection to the shooter foot location.

Abstract: Described herein is an identity network for authenticating a user for a relying party and providing access to the user's credit report. The identity network may receive an unlock request for the digital identity and credit report of a user from a relying party. In response, the identity network may provide an identity provider link for accessing the identity provider application. The user may login to the identity provider application and provide consent for obtaining the user's credit report. The identity provider provides the identity network with verification of the digital identity of the user and the consent response from the user. The identity network can request access from a credit reporting agency and receive a credit report key in response. The identity network can provide the credit report key to the relying party, which can use the key to access the user's credit report from the credit reporting agency.

Abstract: A segmented sole for an article of footwear comprises a forefoot region, a heel region, and a segmentation zone disposed between the forefoot and heel region. The segmentation zone includes a plurality of segments separated from each other and from the forefoot and heel by a plurality of sipes, cuts, or gaps. The segmented sole produces bending along a segmentation axis disposed along an arch of a wearer of an article of footwear including the sole, allowing for arch support and natural foot movement.

Abstract: A fluid preparation device can include a fluid-receiving vessel and a fluid loader with multiple fluid chambers including a first fluid chamber and a second fluid chamber. The multiple fluid chambers can partially be defined by actuator seals that are positioned on an actuator. The actuator can be moveable among a plurality of positions and the actuator seals can be positioned on the actuator to fluidically separate the first fluid chamber from the second fluid chamber when the actuator is in a closed position from the plurality of positions, allow fluidic communication between the second fluid chamber and the fluid-receiving vessel when the actuator is in a first open position from the plurality of positions, and allow fluidic communication between the first fluid chamber and the second fluid chamber when the actuator is in a second open position from the plurality of positions.

Abstract: A multi-access edge computing device may receive historical content data associated with a content application of a user equipment and may process the historical content data, with a machine learning model, to identify content to cache for the user equipment. The multi-access edge computing device may provide, to a content provider device, a request for the content to cache and may receive, from the content provider device, the content to cache based on the request for the content to cache. The multi-access edge computing device may process the content to cache, with a document object model and a browser object model, to generate intermediary content that corresponds to the content to cache. The multi-access edge computing device may store the intermediary content in a data structure associated with the multi-access edge computing device.

Abstract: Provided herein are methods and systems for identifying chimeric nucleic acid fragments, e.g., organism-pathogen chimeric nucleic acid fragments and chromosomal rearrangement chimeric nucleic acid fragments. Also provided herein are methods and systems relating to determining a pathogen integration profile or a chromosomal rearrangement in a biological sample and determining a classification of pathology based at least in part on a pathogen integration profile or a chromosomal rearrangement in a biological sample. In certain aspects of the present disclosure, cell-free nucleic acid molecules from a biological sample are analyzed.

Abstract: A rich communication services (RCS) system may receive a message associated with content. The message may be transmitted by a first user device and destined for a second user device and associated with content. The RCS system may receive subscription data associated with a user of the first user device and including information indicating whether content filtering is enabled for the user. The RCS system may determine whether content filtering is enabled for the user based on the subscription data, and may process the content, when the content filtering is enabled for the user and with a machine learning model, to determine whether to filter the content. The RCS system may perform one or more actions based on whether the content is to be filtered.

Abstract: Example implementations relate to docking stations including cradles. In some examples, a docking station can include a housing including a cradle defining a cavity, the cavity having a width and a depth sufficient to prevent an electronic device coupled to the docking station from decoupling from the docking station responsive to a torque applied on the electronic device, an engagement member to couple to the electronic device when received in the cradle, and a docking connector to transfer data between the docking station and the electronic device when the electronic device is coupled to the docking station.

Abstract: An automated workflow receives a patient study comprising cardiac biomarker measurements and a plurality of echocardiographic images taken by an ultrasound device of a patient heart. A filter separates the plurality of echocardiogram images by 2D images and Doppler modality images based on analyzing image metadata. The 2D images are classified by view type, and the Doppler modality images are classified by view type. The cardiac chambers are segmented in the 2D images, and the Doppler modality images are segmented to generate waveform traces, producing segmented 2D images and segmented Doppler modality images. Using both the sets of images, measurements of cardiac features for both left and right sides of the heart are calculated. The cardiac biomarker measurements and the calculated measurements are compared with international cardiac guidelines to generate conclusions, and a report is output showing the measurements that fall within or outside of the guidelines.

Abstract: Disclosed herein are methods of increasing response to radiation therapy in subjects afflicted with cancer. In some embodiments, the method comprises reducing the ability of an immune suppressor cell (e.g., MDSC) to migrate to the microenvironment of the cancer. In some embodiments, the method further comprises suppressing the migration of the immune suppressor cell to a non-malignant cell and/or suppressing the malignant transformation of the non-malignant cells.

Abstract: A music playback method for determining, based on image information, whether to play music, includes obtaining at least one detection position image through an image sensing apparatus; determining whether the detection position image meets at least one playback trigger threshold; and starting an audio playback device based on a result of whether the detection position image meets the playback trigger threshold, to output at least one piece of audio content.

Abstract: The inventions cover systems and methods for generation of emulsions having suitable clarity without requiring refractive index matching between emulsion components. Systems can include: a substrate including a set of openings; a reservoir facing the substrate at a first side and containing a sample fluid configured for droplet formation upon interacting with the set of openings of the substrate; and a collecting container facing the substrate at a second side and containing a set of fluid layers configured with a density gradient and suitable immiscibility characteristics. One or more components of the system(s) can support methods for emulsion generation, in relation to enabling interactions between multiple continuous phases and a dispersed droplet phase to generate clear emulsions. Applications of the inventions(s) can include performance of droplet-based digital PCR in an improved manner (e.g., without requiring implementation of correction factors based upon Poisson statistics).