Patents by Inventor Forrest K. Ferrari

Forrest K. Ferrari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Helper virus-free AAV production
    Patent number: 8809058
    Abstract: A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: August 19, 2014
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Forrest K. Ferrari, Xiao Xiao, Richard Jude Samulski
  • HELPER VIRUS-FREE AAV PRODUCTION
    Publication number: 20090004743
    Abstract: A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.
    Type: Application
    Filed: June 17, 2008
    Publication date: January 1, 2009
    Inventors: Forrest K. Ferrari, Xiao Xiao, Richard Jude Samulski
  • Helper virus-free AAV production
    Patent number: 7439065
    Abstract: A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: October 21, 2008
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Forrest K. Ferrari, Xiao Xiao, Richard Jude Samulski
  • Helper virus-free AAV production
    Patent number: 6951758
    Abstract: A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.
    Type: Grant
    Filed: July 13, 2004
    Date of Patent: October 4, 2005
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Forrest K. Ferrari, Xiao Xiao, Richard Jude Samulski
  • Helper virus-free AAV production
    Publication number: 20030013197
    Abstract: A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.
    Type: Application
    Filed: August 16, 2002
    Publication date: January 16, 2003
    Inventors: Forrest K. Ferrari, Xiao Xiao, Richard Jude Samulski
  • Helper virus-free AAV production
    Patent number: 6458587
    Abstract: A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: October 1, 2002
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Forrest K. Ferrari, Xiao Xiao, Richard Jude Samulski
  • Helper virus-free AAV production
    Publication number: 20010039044
    Abstract: A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.
    Type: Application
    Filed: March 21, 2001
    Publication date: November 8, 2001
    Inventors: Forrest K. Ferrari, Xiao Xiao, Richard Jude Samulski
  • AAV capsid vehicles for molecular transfer
    Publication number: 20010016355
    Abstract: The invention relates to the production of AAV capsids which may be used to transfer native or heterologous molecules into appropriate host cells. The capsid proteins can be expressed from a recombinant virus, expression vector, or from a cell line that has stably integrated the AAV capsid genes or coding sequences. The invention further provides for the production of AAV capsids in vitro from the AAV capsid proteins and the construction of packaged capsids in vitro. The invention further provides for the production of AAV capsids that have been genetically engineered to express heterologous epitopes of clinically important antigens to elicit an immune response.
    Type: Application
    Filed: December 22, 2000
    Publication date: August 23, 2001
    Applicant: University of Pittsburgh
    Inventors: Richard Jude Samulski, Forrest K. Ferrari
  • AAV capsid vehicles for molecular transfer
    Patent number: 6204059
    Abstract: The invention relates to the production of AAV capsids which may be used to transfer native or heterologous molecules into appropriate host cells. The capsid proteins can be expressed from a recombinant virus, expression vector, or from a cell line that has stably integrated the AAV capsid genes or coding sequences. The invention further provides for the production of AAV capsids in vitro from the AAV capsid proteins and the construction of packaged capsids in vitro. The invention further provides for the production of AAV capsids that have been genetically engineered to express heterologous epitopes of clinically important antigens to elicit an immune response.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: March 20, 2001
    Assignee: University of Pittsburgh
    Inventors: Richard Jude Samulski, Forrest K. Ferrari
  • Helper virus-free AAV production
    Patent number: 6093570
    Abstract: A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 25, 2000
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Forrest K. Ferrari, Xiao Xiao, Richard Jude Samulski
  • Helper virus-free AAV production
    Patent number: 6040183
    Abstract: A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 21, 2000
    Assignee: University of North Carloina at Chapel Hill
    Inventors: Forrest K. Ferrari, Xiao Xiao, Richard Jude Samulski
  • AAV capsid vehicles for molecular transfer
    Patent number: 5863541
    Abstract: The invention relates to the production of AAV capsids which may be used to transfer native or heterologous molecules into appropriate host cells. The capsid proteins can be expressed from a recombinant virus, expression vector, or from a cell line that has stably integrated the AAV capsid genes or coding sequences. The invention further provides for the production of AAV capsids in vitro from the AAV capsid proteins and the construction of packaged capsids in vitro. The invention further provides for the production of AAV capsids that have been genetically engineered to express heterologous epitopes of clinically important antigens to elicit an immune response.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 26, 1999
    Assignee: University of Pittsburgh
    Inventors: Richard Jude Samulski, Forrest K. Ferrari