Abstract: A system and method are disclosed that include a wearable biosensing device mounted over or proximate to a vessel of a patient enabling biosensing data to be obtained or captured by the wearable biosensing device. Operations of the method or performed by logic of the system are directed at determining patient health-related predictions of a first patient and include obtaining patient health data including at least biosensing data obtained from a wearable biosensing device of the first patient, wherein the biosensing data includes one or more of raw signals captured by the wearable biosensing device or a first metric provided by the wearable biosensing device, evaluating the patient health data by applying one or more machine learning techniques that receive the patient health data as input resulting in a first patient health-related prediction, and generating a graphical user interface illustrating the first patient health-related prediction.

Abstract: Systems and methods disclosed herein are directed to determining serum potassium levels of a patient wearing a biosensing device. A first such method includes operations of capturing a first energy measurement reading by an energy detecting element of an optical sensor, wherein the optical sensor is a component of a biosensing device, and wherein the biosensing device is disposed on a skin surface of the patient, performing a feature extraction on the first energy measurement reading resulting in a feature vector representative of volumetric variations in blood flow of the patient, deploying a trained machine learning model configured to take the feature vector as input and determine a serum potassium level classification of the patient at a time corresponding to when the first energy measurement reading was captured, and generating a graphic user interface (GUI) that displays the serum potassium level classification.

Abstract: Systems and methods of the disclosure are directed to the personalization of machine learning models configured to generate patient health-related predictions for a patient wearing a biosensing device. The biosensing device may be mounted over or proximate to a vessel of a patient enabling biosensing data to be obtained or captured by the biosensing device. Particular implementations of the disclosure are directed to training a machine learning model to generate patient health-related predictions for a patient and retraining the machine learning model over time using data captured by the biosensing device worn by the patient to personalize the machine learning model to the individual patient. As a result, the personalized machine learning model enables the provision of precision medicine through the tailoring of the historical data on which the machine learning is trained.

Abstract: Systems and methods for monitoring blood flow metrics using a patch of a flexible substrate configured to attach to an area of skin over a blood vessel. The patch includes a plurality of light sources arranged on the substrate to form a matrix and a row of photodetectors disposed on the substrate substantially in parallel with the rows of LEDs. The patch includes an optical signal interface configured to drive each light source and to input an intensity signal at one of the photodetectors. The intensity signals are used to determine AC and DC components corresponding to each optical path. AC to DC component ratios are calculated for each optical path and used to determine ratio-of-ratio values. At least a subset of the ratio-of-ratio values are used to determine a biological metric or a cross-sectional area of the blood vessel.

Abstract: A system, device and method for measuring markers for a periprosthetic joint infection in a sample of synovial fluid. A sensor reader device includes a vial receptacle for receiving a vial containing synovial fluid. A light source illuminates the vial and an optical sensor detects light scattered and/or absorbed by white blood cells in the fluid sample. An electrical signal corresponding to the intensity of the light received at the optical sensor is detected. A white blood cell concentration is determined from the electrical signal value. The sensor reader device also includes one or more immunoassay strip receptacles. Immunoassay strips for other marker are inserted into the receptacles. Immunoassay optical sensors detect light generated by the immunoassay reaction on the immunoassay strip to determine the concentration of the marker. In example implementations, the device includes an immunoassay strip reader for leukocyte esterase and c-reactive protein.

Abstract: Systems and methods for monitoring blood flow metrics using a patch of a flexible substrate configured to attach to an area of skin over a blood vessel. The patch includes a plurality of light sources arranged on the substrate to form a matrix and a row of photodetectors disposed on the substrate substantially in parallel with the rows of LEDs. The patch includes an optical signal interface configured to drive each light source and to input an intensity signal at one of the photodetectors. The intensity signals are used to determine AC and DC components corresponding to each optical path. AC to DC component ratios are calculated for each optical path and used to determine ratio-of-ratio values. At least a subset of the ratio-of-ratio values are used to determine a biological metric or a cross-sectional area of the blood vessel.

Abstract: A system, device and method for measuring markers for a periprosthetic joint infection in a sample of synovial fluid. A sensor reader device includes a vial receptacle for receiving a vial containing synovial fluid. A light source illuminates the vial and an optical sensor detects light scattered and/or absorbed by white blood cells in the fluid sample. An electrical signal corresponding to the intensity of the light received at the optical sensor is detected. A white blood cell concentration is determined from the electrical signal value. The sensor reader device also includes one or more immunoassay strip receptacles. Immunoassay strips for other marker are inserted into the receptacles. Immunoassay optical sensors detect light generated by the immunoassay reaction on the immunoassay strip to determine the concentration of the marker. In example implementations, the device includes an immunoassay strip reader for leukocyte esterase and c-reactive protein.

Abstract: This invention relates to diagnostic medical instruments and procedures, and more particularly to implantable devices and methods for monitoring physiological parameters. A device for providing in vivo diagnostics of infections in orthopedic implants having at least one signal processing device operatively coupled with sensors. The signal processing device is operable to receive the output signal from the sensors and transmit a signal corresponding with the output signal. The invention also relates to a method using the device of the invention for detecting infection associated with implants in a human or animal subject.

Abstract: This invention relates to diagnostic medical instruments and procedures, and more particularly to implantable devices and methods for monitoring physiological parameters. A device for providing in vivo diagnostics of infections in orthopedic implants having at least one signal processing device operatively coupled with sensors. The signal processing device is operable to receive the output signal from the sensors and transmit a signal corresponding with the output signal. The invention also relates to a method using the device of the invention for detecting infection associated with implants in a human or animal subject.

Abstract: To assist diagnosis of a post-operative condition related to an implanted medical device, such as an infection, inflammation, mechanical wear, and hemorrhaging, a monitoring device optically measures a concentration of a selected type of cells in a fluid surrounding the implanted medical device. The monitoring device comprises a light source and light sensor which are selected and calibrated, and placed in a relative spatial orientation with respect to each other, to detect light scattered by the selected type of cell in the fluid.