Patents by Inventor Fozan El-Nounou
Fozan El-Nounou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9561351Abstract: An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.Type: GrantFiled: May 31, 2006Date of Patent: February 7, 2017Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Klaus Kleine, David C. Gale, Fozan El-Nounou, Syed F. A. Hossainy, Florian Ludwig
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Patent number: 9242005Abstract: Pro-healing agent formulation compositions, methods and treatments for enhancing vascular healing are disclosed herein. In some embodiments, a pro-healing agent is encapsulated, suspended, disposed within or loaded into a biodegradable carrier for sustained-release delivery to a denuded or damaged endothelium treatment area in a blood vessel. In some applications, the pro-healing agent can accelerate re-endothelialization of a denuded vascular region. In some applications, the pro-healing agent can assist in the regaining of endothelium functionality. The formulation can be delivered by a delivery assembly such as an infusion catheter, a porous balloon catheter, a needle injection catheter, a double balloon catheter or the like.Type: GrantFiled: August 21, 2006Date of Patent: January 26, 2016Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed Hossainy, Florian Niklas Ludwig, Stephen Pacetti, Paul Consigny, Fozan El-Nounou, Thierry Glauser, Jessica DesNoyer
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Patent number: 8895056Abstract: The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.Type: GrantFiled: December 21, 2012Date of Patent: November 25, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: Stephen D. Pacetti, Paul M. Consigny, Ronald W. Heil, Jr., Florian Niklas Ludwig, Dariush Davalian, Li Zhao, Irina Astafieva, Jinping Wan, Fozan El-Nounou, Katsuyuki Murase, Syed F. A. Hossainy, Rachel Bright, Jeffrey Ellis
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Patent number: 7951413Abstract: A balloon for a catheter and a method of making the balloon, having a layer of a porous polymeric material with a modified outer surface and a lubricious coating bonded to the modified outer surface. In one embodiment, the modified outer surface is formed by a polymer impregnated in the porous polymeric material, and the subsequently applied lubricious coating bonds to the impregnating polymer. In another embodiment, the modified outer surface is formed by a functionality deposited on the porous polymeric material which bonds to the subsequently applied lubricious coating. The modified outer surface provides an improved strong bond between the lubricious coating and the balloon, for improved catheter performance.Type: GrantFiled: October 18, 2006Date of Patent: May 31, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: Fozan El-Nounou, Timothy Owens, Florencia Lim, Edwin Wang
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Publication number: 20100100169Abstract: A method of modifying a medical device such as a stent with nano-constructs is disclosed. The method comprises applying a first fluid to the stent; immersing the stent being wet from the first fluid into a second fluid having a suspension of nano-constructs; and removing the stent from the second fluid and allowing the first and second fluid to be removed such that the nano-constructs are carried by the stent for in vivo application of the constructs to a target location of a mammalian subject. The nano-constructs can be attached to the surface of the stent, can be attached to a surface of the coating of the stent, can be embedded into the stent, or can be embedded into the coating.Type: ApplicationFiled: May 30, 2007Publication date: April 22, 2010Inventors: Syed F. A. Hossainy, Dariush Davalian, Jinping Wan, Troy Carter, Charles Silvis, Fozan El-Nounou
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Publication number: 20080146489Abstract: The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.Type: ApplicationFiled: December 15, 2006Publication date: June 19, 2008Inventors: Stephen D. Pacetti, Paul M. Consigny, Ronald W. Heil, Florian Niklas Ludwig, Dariush Davalian, Li Zhao, Irina Astafieva, Jinping Wan, Fozan El-Nounou, Katsuyuki Murase, Syed F.A. Hossainy, Rachel Bright, Jeffrey Ellis
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Patent number: 7351238Abstract: A catheter having a mandrel secured to the catheter or constrained within a dedicated lumen. In one embodiment, the catheter has an inner tubular member and an outer tubular member with a sidewall configured to define a mandrel lumen longitudinally along an inner surface of the outer tubular member or along an outer surface of the inner tubular member. The mandrel lumen may be configured to allow the mandrel to be exchanged to adjust the handling characteristics of the catheter. The mandrel may occupy an intermediate portion of the catheter shaft, or may extend from the proximal end to within proximal or distal shaft sections of the catheter. In coronary artery applications, the mandrel is configured to support the catheter as it bends through the aortic arch and enters the coronary artery.Type: GrantFiled: October 22, 2003Date of Patent: April 1, 2008Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Jeong Soo Lee, Tim Geiser, Sandra K. Schenk, Terry Freeman, Cheri Stiger, Fozan El-Nounou
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Publication number: 20070282425Abstract: An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.Type: ApplicationFiled: May 31, 2006Publication date: December 6, 2007Inventors: Klaus Kleine, David C. Gale, Fozan El-Nounou, Syed F.A. Hossainy, Florian Ludwig
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Publication number: 20070250035Abstract: A catheter configured for delivering an agent to a patient's vessel wall, having self-expanding frame, and a method of delivering an agent to a patient's vessel wall. A first catheter has an elongated shaft with an agent delivery lumen and self-expanding frame on a distal shaft section formed of plurality of hollow tubes having joined first ends and free second ends, the free end of each hollow tube having an agent delivery port in fluid communication with the shaft agent delivery lumen and having a hooked tip configured for penetrating the vessel wall in the expanded configuration. Another catheter has a frame around the outer surface of a lining member such as a balloon or a tubular sleeve, such that the frame expanded against the vessel wall and the lining member together define a plurality of pockets between the vessel wall and the outer surface of the lining member.Type: ApplicationFiled: April 19, 2006Publication date: October 25, 2007Inventors: Fozan El-Nounou, Paul Consigny, Florian Ludwig
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Publication number: 20070142819Abstract: A bifurcated catheter having a branched distal shaft section and one or more porous or nonporous balloons, and combinations thereof, which is configured for delivery of an agent to a patient's bifurcated body lumen. Another aspect of the invention is directed to a method of delivering an agent to a patient's body lumen which facilitates maximizing the efficiency of drug uptake into the tissue at the desired site within the patient's body lumen.Type: ApplicationFiled: December 20, 2005Publication date: June 21, 2007Inventors: Fozan El-Nounou, Florian Ludwig
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Publication number: 20070032760Abstract: A balloon for a catheter and a method of making the balloon, having a layer of a porous polymeric material with a modified outer surface and a lubricious coating bonded to the modified outer surface. In one embodiment, the modified outer surface is formed by a polymer impregnated in the porous polymeric material, and the subsequently applied lubricious coating bonds to the impregnating polymer. In another embodiment, the modified outer surface is formed by a functionality deposited on the porous polymeric material which bonds to the subsequently applied lubricious coating. The modified outer surface provides an improved strong bond between the lubricious coating and the balloon, for improved catheter performance.Type: ApplicationFiled: October 18, 2006Publication date: February 8, 2007Inventors: Fozan El-Nounou, Timothy Owens, Florencia Lim, Edwin Wang
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Patent number: 7172575Abstract: A balloon for a catheter and a method of making the balloon, having a layer of a porous polymeric material with a modified outer surface and a lubricious coating bonded to the modified outer surface. In one embodiment, the modified outer surface is formed by a polymer impregnated in the porous polymeric material, and the subsequently applied lubricious coating bonds to the impregnating polymer. In another embodiment, the modified outer surface is formed by a functionality deposited on the porous polymeric material which bonds to the subsequently applied lubricious coating. The modified outer surface provides an improved strong bond between the lubricious coating and the balloon, for improved catheter performance.Type: GrantFiled: March 5, 2003Date of Patent: February 6, 2007Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Fozan El-Nounou, Timothy Owens, Florencia Lim, Edwin Wang
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Publication number: 20060184111Abstract: A method of making a catheter balloon, and a balloon catheter formed thereby, in which a layer of a catheter balloon is formed by decreasing the inner diameter of a first end section of a polymeric tube, so that the tube has a reduced diameter first end section with an inner diameter less than the inner diameter of a central section of the tube. The reduced diameter first end section of the tube is bonded to a catheter shaft to form at least a portion of a skirt section of the balloon, and the skirt section has an improved high rupture pressure.Type: ApplicationFiled: January 31, 2006Publication date: August 17, 2006Inventors: Florencia Lim, Fozan El-Nounou, Alfredo Bayot
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Patent number: 7025745Abstract: A method of making a catheter balloon, and a balloon catheter formed thereby, in which a layer of a catheter balloon is formed by decreasing the inner diameter of a first end section of a polymeric tube, so that the tube has a reduced diameter first end section with an inner diameter less than the inner diameter of a central section of the tube. The reduced diameter first end section of the tube is bonded to a catheter shaft to form at least a portion of a skirt section of the balloon, and the skirt section has an improved high rupture pressure.Type: GrantFiled: October 7, 2002Date of Patent: April 11, 2006Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Florencia Lim, Fozan El-Nounou, Alfredo Bayot
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Publication number: 20040175558Abstract: A balloon for a catheter and a method of making the balloon, having a layer of a porous polymeric material with a modified outer surface and a lubricious coating bonded to the modified outer surface. In one embodiment, the modified outer surface is formed by a polymer impregnated in the porous polymeric material, and the subsequently applied lubricious coating bonds to the impregnating polymer. In another embodiment, the modified outer surface is formed by a functionality deposited on the porous polymeric material which bonds to the subsequently applied lubricious coating. The modified outer surface provides an improved strong bond between the lubricious coating and the balloon, for improved catheter performance.Type: ApplicationFiled: March 5, 2003Publication date: September 9, 2004Inventors: Fozan El-Nounou, Timothy Owens, Florencia Lim, Edwin Wang
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Patent number: 6733486Abstract: A catheter having a mandrel secured to the catheter or constrained within a dedicated lumen. In one embodiment, the catheter has an inner tubular member and an outer tubular member with a sidewall configured to define a mandrel lumen longitudinally along an inner surface of the outer tubular member or along an outer surface of the inner tubular member. The mandrel lumen may be configured to allow the mandrel to be exchanged to adjust the handling characteristics of the catheter. The mandrel may occupy an intermediate portion of the catheter shaft, or may extend from the proximal end to within proximal or distal shaft sections of the catheter. In coronary artery applications, the mandrel is configured to support the catheter as it bends through the aortic arch and enters the coronary artery.Type: GrantFiled: December 22, 1999Date of Patent: May 11, 2004Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Jeong Soo Lee, Tim Geiser, Sandra K. Schenk, Terry Freeman, Cheri Stiger, Fozan El-Nounou
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Publication number: 20040082935Abstract: A catheter having a mandrel secured to the catheter or constrained within a dedicated lumen. In one embodiment, the catheter has an inner tubular member and an outer tubular member with a sidewall configured to define a mandrel lumen longitudinally along an inner surface of the outer tubular member or along an outer surface of the inner tubular member. The mandrel lumen may be configured to allow the mandrel to be exchanged to adjust the handling characteristics of the catheter. The mandrel may occupy an intermediate portion of the catheter shaft, or may extend from the proximal end to within proximal or distal shaft sections of the catheter. In coronary artery applications, the mandrel is configured to support the catheter as it bends through the aortic arch and enters the coronary artery.Type: ApplicationFiled: October 22, 2003Publication date: April 29, 2004Inventors: Jeong Soo Lee, Tim Geiser, Sandra K. Schenk, Terry Freeman, Cheri Stiger, Fozan El-Nounou
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Publication number: 20040068287Abstract: A method of making a catheter balloon, and a balloon catheter formed thereby, in which a layer of a catheter balloon is formed by decreasing the inner diameter of a first end section of a polymeric tube, so that the tube has a reduced diameter first end section with an inner diameter less than the inner diameter of a central section of the tube. The reduced diameter first end section of the tube is bonded to a catheter shaft to form at least a portion of a skirt section of the balloon, and the skirt section has an improved high rupture pressure.Type: ApplicationFiled: October 7, 2002Publication date: April 8, 2004Inventors: Florencia Lim, Fozan El-Nounou, Alfredo Bayot
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Patent number: 6695793Abstract: An improved guide catheter provides a distal tip with one or more members that assist a surgeon with locating and inserting the guide catheter through the ostium in the wall of the right atrium that leads to the coronary sinus of the heart. The guide catheter is used to implant a cardiac lead so that its electrodes are positioned in the vasculature associated with the left side of the heart.Type: GrantFiled: July 31, 2001Date of Patent: February 24, 2004Assignee: Cardiac Pacemakers, Inc.Inventors: Lawrence Brennan, Fozan El-Nounou
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Publication number: 20030208221Abstract: A catheter having an elongated shaft with a proximal shaft section and a distal shaft section, and having a support member with a proximal end within the proximal shaft section, a distal end within the distal shaft section, and at least a section which is coiled. In a presently preferred embodiment, the support member is a wire, and preferably a solid wire formed of a metal such as a stainless steel or super elastic alloy such as a nickel-titanium (Nitinol) alloy. In a presently preferred embodiment, the proximal shaft section comprises a high strength tubular member, such as a metallic tubular member. The catheter of the invention is highly pushable, flexible, trackable and kink resistant with the support member extending from the distal end of the relatively stiff proximal shaft section at the junction between the proximal and distal shaft sections.Type: ApplicationFiled: May 2, 2002Publication date: November 6, 2003Inventor: Fozan El-Nounou