Patents by Inventor Frédéric CHIAMBARETTA

Frédéric CHIAMBARETTA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220175878
    Abstract: Eye drops containing cyclosporin A are prepared in the form of an emulsion, a microemulsion, or a lipophilic/hydrophilic micellar solution whose lipophilic, and hence oily, phase contains cyclosporin A. Preparation of the eye drops begins by eliminating at least 99 wt % of ethanol contained in an oily solution of cyclosporin A, under a flow of nitrogen under a pressure of 0.5 bar, at a temperature of from 2° C. to 45° C. and for a period of from 0.25 h to 24 h. The concentrate of cyclosporine is then diluted in an aqueous solution. Next, an emulsion, a microemulsion, or a micellar solution being 75% aqueous phase is created by stirring the concentrated cyclosporine A with the aqueous solution to mix them together. The resulting mixture is sterilely packaged as eye drops in packaging that is suitable for ophthalmic use.
    Type: Application
    Filed: February 28, 2022
    Publication date: June 9, 2022
    Inventors: Philip CHENNELL, Frederic CHIAMBARETTA, Lucie DELABORDE, Mireille JOUANNET, Valerie SAUTOU
  • Publication number: 20180296633
    Abstract: A method for preparing eye drops of cyclosporin A in the form of an emulsion, a microemulsion, or a lipophilic/hydrophilic micellar solution whose lipophilic—and hence oily—phase contains cyclosporin A, characterized in that it comprises at least the following steps: a) eliminating at least 99 wt % of the ethanol contained in the oily solution of cyclosporin A, under a flow of nitrogen under a pressure of 0.5 bar, at a temperature of from 2° C. to 45° C. and for a period of from 0.25 h to 24 h, b) diluting the concentrate obtained in step a) in an aqueous solution, c) forming an emulsion, a microemulsion, or a micellar solution in which the aqueous phase makes up at least 75% of the final emulsion, microemulsion, or micellar solution, by stirring to mix the concentrated oily solution obtained in step a) with the diluted aqueous solution obtained in step b), d) sterile packaging of the obtained eye drops in packaging that is suitable for ophthalmic use.
    Type: Application
    Filed: September 29, 2016
    Publication date: October 18, 2018
    Inventors: Philip CHENNELL, Frédéric CHIAMBARETTA, Lucie DELABORDE, Mireille JOUANNET, Valérie SAUTOU