Abstract: This invention relates to a self-degradable optical fiber, that is to say, an optical fiber that contains, within its own structure, compounds capable of leading to its degradation. This optical fiber comprises a core, a sheath and a polymer coating, in which at least one calixarene is incorporated in the coating, the calixarene(s) imprisoning at least one compound capable of being released under defined conditions of temperature and/or humidity and/or irradiation and of bringing about degradation of the coating. The invention also relates to a method of preparing this fiber and a wire guided device comprising this fiber.