Patents by Inventor Frédéric Heitz
Frédéric Heitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8354387Abstract: Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.Type: GrantFiled: February 23, 2009Date of Patent: January 15, 2013Assignee: Centre National de la Recherche ScientifiqueInventors: Gilles Divita, May Catherine Morris, Frédéric Heitz, Federica Simeoni
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Patent number: 8242081Abstract: The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9RALX9RX1LX2RSLX9X3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.Type: GrantFiled: December 5, 2006Date of Patent: August 14, 2012Assignees: Centre National de la Recherche Scientifique, Affymetrix, Inc.Inventors: Gilles Divita, Frédéric Heitz, May Catherine Morris, Gudrun Aldrian-Herrada
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Patent number: 7943581Abstract: The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8(SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.Type: GrantFiled: December 30, 2008Date of Patent: May 17, 2011Assignees: Centre National de laRecherche de la Recherche, AFFYMETRIX, Inc.Inventors: Gilles Divita, Frederic Heitz, Catherine May Morris, Gudrun Aldrian-Herrada
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Publication number: 20110064793Abstract: The invention is drawn to a novel class of drugs directed against HIV, comprising a peptide or analog comprising a decapeptide, said decapeptide containing (from N-terminus to the C-terminus) a basic amino acid in position 1, an acidic amino acid in positions 2 and 5, and a tryptophan in positions 4, 7, and 8, and to a method of treatment of HIV infections, in particular multidrug-resistant HIV infections.Type: ApplicationFiled: August 16, 2010Publication date: March 17, 2011Applicant: Centre National De La Recherche Scientifique (C.N.R.S.)Inventors: Christian DeVaux, Véronique Hebmann, Gilles Divita, Frédéric Heitz, Catherine May Morris, Jean Mery, Roger S. Goody
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Patent number: 7790171Abstract: The invention is drawn to a novel class of drugs directed against HIV, comprising a peptide or analog comprising a decapeptide, said decapeptide containing (from N-terminus to the C-terminus) a basic amino acid in position 1, an acidic amino acid in positions 2 and 5, and a tryptophan in positions 4, 7, and 8, and to a method of treatment of HIV infections, in particular multidrug-resistant HIV infections.Type: GrantFiled: August 25, 2000Date of Patent: September 7, 2010Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Christian Devaux, Véronique Hebmann, Gilles Divita, Frédéric Heitz, Catherine May Morris, Jean Mery, Roger S. Goody
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Publication number: 20100099626Abstract: The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.Type: ApplicationFiled: December 30, 2008Publication date: April 22, 2010Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, PANOMICS, INC.Inventors: Gilles DIVITA, Frederic HEITZ, Catherine MORRIS, Gudrun ALDRIAN-HERRADA
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Publication number: 20090292003Abstract: The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9RALX9RX1LX2RSLX9X3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.Type: ApplicationFiled: December 5, 2006Publication date: November 26, 2009Applicants: Centre National De La Recherche Scientifique, Panomics Inc.Inventors: Gilles Divita, Frederic Heitz, May Catherine Morris, Gudrun Aldrian-Herrada
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Publication number: 20090258926Abstract: Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.Type: ApplicationFiled: February 23, 2009Publication date: October 15, 2009Applicant: Centre National De La Recherche ScientifiqueInventors: Gilles Divita, May Catherine Morris, Frederic Heitz, Federica Simeoni
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Patent number: 7579318Abstract: The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.Type: GrantFiled: December 6, 2005Date of Patent: August 25, 2009Assignees: Centre de la Recherche de la Scientifique, Panomics, Inc.Inventors: Gilles Divita, Frédéric Heitz, Catherine May Morris, Gudrun Aldrian-Herrada
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Publication number: 20090156503Abstract: The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8(SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.Type: ApplicationFiled: December 30, 2008Publication date: June 18, 2009Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENT, GENOSPECTRA, INC.Inventors: GILLES DIVITA, FREDERIC HEITZ, CATHERINE MAY MORRIS, GUDRUN ALDRIAN-HERRADA
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Patent number: 7514530Abstract: Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.Type: GrantFiled: April 26, 2004Date of Patent: April 7, 2009Assignee: Centre National de la Recherche ScientifiqueInventors: Gilles Divita, May Catherine Morris, Frédéric Heitz, Federica Simeoni
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Publication number: 20070129305Abstract: The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.Type: ApplicationFiled: December 6, 2005Publication date: June 7, 2007Applicants: Centre National De La Recherche Scient., GENOSPECTRA, Inc.Inventors: Gilles Divita, Frederic Heitz, Catherine Morris, Gudrun Aldrian-Herrada
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Publication number: 20050239687Abstract: Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.Type: ApplicationFiled: April 26, 2004Publication date: October 27, 2005Inventors: Gilles Divita, May Morris, Frederic Heitz, Federica Simeoni
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Patent number: 6841535Abstract: Peptides that are useful as transfection agents are described. The peptides can facilitate the efficient cellular internalization of a broad range and size of compounds that when non-covalently complexed therewith are efficiently internalized into a cell. Advantages include but are not limited to excellent transfection efficiency, relatively low toxicity, internalization by a broad host cell spectrum, and the simplicity and cost-effectiveness that arise from not having to covalently complex the peptide with a specific molecule to be delivered. Applications include but are not limited to the delivery of diagnostics and therapeutics, as well as drug discovery, gene discovery, and the analysis and/or manipulation of other cellular and molecular biological functions. Claims are made for transfection agents, compositions of matter, including pharmaceutical compositions, reagent kits, methods of delivery, and methods of identification of additional peptides for performing and/or including in the same.Type: GrantFiled: July 26, 2001Date of Patent: January 11, 2005Assignees: Active Motif, Centre National de la Recherche ScientifiqueInventors: Gilles Divita, May C. Morris, Jean Mery, Frederic Heitz, Joseph Fernandez, John Archdeacon, Kyle Horndorp
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Publication number: 20030119725Abstract: Peptides that are useful as transfection agents are described. The peptides can facilitate the efficient cellular internalization of a broad range and size of compounds that when non-covalently complexed therewith are efficiently internalized into a cell. Advantages include but are not limited to excellent transfection efficiency, relatively low toxicity, internalization by a broad host cell spectrum, and the simplicity and cost-effectiveness that arise from not having to covalently complex the peptide with a specific molecule to be delivered. Applications include but are not limited to the delivery of diagnostics and therapeutics, as well as drug discovery, gene discovery, and the analysis and/or manipulation of other cellular and molecular biological functions. claims are made for transfection agents, compositions of matter, including pharmaceutical compositions, reagent kits, methods of delivery, and methods of identification of additional peptides for performing and/or including in the same.Type: ApplicationFiled: July 26, 2001Publication date: June 26, 2003Inventors: Gilles Divita, May C. Morris, Jean Mery, Frederic Heitz, Joseph Fernandez, John Archdeacon, Kyle Hondorp