Patents by Inventor Frédéric Ran

Frédéric Ran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10919041
    Abstract: In a method of analyzing solid form properties of a substance, which including the step of solidifying the substance, the solidified substance is obtained in one of a plurality of wells of a multi-well plate. In the multi-well plate the at least one of the plurality of wells has a bottom made of a thermoplastic polyimide. The method further includes analyzing the solidified substance in the well of the multi-well plate by X-ray diffraction. Thereby, the analysis includes providing X-ray through the solidified substance and a bottom of the well and evaluating the X-ray which passed the solidified substance and the bottom of the well. Such method and multi-well plate provide a durable and cost efficient system allowing a high quality analysis of solid form properties of the substance and an efficient and safe processing of the substance.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: February 16, 2021
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Urs Schwitter, Frédéric Ran, André Alker, Tom Kissling, Thomas Zumstein
  • Patent number: 10759800
    Abstract: The present invention relates to crystalline forms of a diazabicyclooctane derivative represented by Compound I, the process for producing the same and methods for using the same:
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: September 1, 2020
    Assignees: FEDORA PHARMACEUTICALS INC., MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Michael Kammerer, Frederic Ran
  • Patent number: 10584123
    Abstract: The present invention relates to a process for producing crystalline and amorphous forms of a diazabicyclooctane derivative represented by Compound (I) and methods for producing the same.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: March 10, 2020
    Assignees: FEDORA PHARMACEUTICALS INC., MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Michael Kammerer, Frédéric Ran
  • Publication number: 20190293576
    Abstract: A sample holder (1) for containing a substance in a solid form screening process comprises a body (2) with a sidewall portion (21), a bottom portion (22) and a hollow interior limited by the sidewall portion (21) and the bottom portion (22). The bottom portion (22) is made of a thermoplastic polyimide. The sample holder (1) allows for providing a high quality analysis of solid form properties of a substance and an efficient and safe processing of the substance.
    Type: Application
    Filed: October 27, 2017
    Publication date: September 26, 2019
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Urs SCHWITTER, Frédéric RAN, André ALKER, Tom KISSLING, Thomas ZUMSTEIN
  • Publication number: 20190291104
    Abstract: In a method of analyzing solid form properties of a substance, which including the step of solidifying the substance, the solidified substance is obtained in one of a plurality of wells of a multi-well plate. In the multi-well plate the at least one of the plurality of wells has a bottom made of a thermoplastic polyimide. The method further includes analyzing the solidified substance in the well of the multi-well plate by X-ray diffraction. Thereby, the analysis includes providing X-ray through the solidified substance and a bottom of the well and evaluating the X-ray which passed the solidified substance and the bottom of the well. Such method and multi-well plate provide a durable and cost efficient system allowing a high quality analysis of solid form properties of the substance and an efficient and safe processing of the substance.
    Type: Application
    Filed: October 27, 2017
    Publication date: September 26, 2019
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Urs SCHWITTER, Frédéric RAN, André ALKER, Tom KISSLING, Thomas ZUMSTEIN
  • Publication number: 20190194210
    Abstract: The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Benno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels
  • Publication number: 20190106421
    Abstract: The present invention relates to a process for producing crystalline and amorphous forms of a diazabicyclooctane derivative represented by Compound (I) and methods for producing the same.
    Type: Application
    Filed: September 25, 2018
    Publication date: April 11, 2019
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Michael KAMMERER, Frédéric RAN
  • Patent number: 10246460
    Abstract: The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: April 2, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Benno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels
  • Publication number: 20190092773
    Abstract: The present invention relates to crystalline forms of a diazabicyclooctane derivative represented by Compound I, the process for producing the same and methods for using the same:
    Type: Application
    Filed: September 25, 2018
    Publication date: March 28, 2019
    Inventors: Michael KAMMERER, Frédéric RAN
  • Publication number: 20160280712
    Abstract: The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 29, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Benno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels
  • Patent number: 7438861
    Abstract: A heatable pipette, with a needle has an inner channel defined by an inner wall, arranged to conduct electric current through the inner wall for resistively heating the inner wall. The needle has an outer wall, which is defined between the outer wall and the inner wall and connectable for providing pressure air into the outer channel. By conducting current directly through the inner wall, the inner wall itself operates as resistor. Particularly, if the inner wall is made of an appropriate material, for example of stainless steel, the ohmic resistance of the inner wall is not negligible even if the inner wall is very thin. Therefore, the inner wall can directly be used as resistor for resistance heating of the inner wall even if the needle is manufactured in small dimensions.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: October 21, 2008
    Assignee: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Frédéric Ran
  • Publication number: 20070274870
    Abstract: A heatable pipette, with a needle has an inner channel defined by an inner wall, arranged to conduct electric current through the inner wall for resistively heating the inner wall. The needle has an outer wall, which is defined between the outer wall and the inner wall and connectable for providing pressure air into the outer channel. By conducting current directly through the inner wall, the inner wall itself operates as resistor. Particularly, if the inner wall is made of an appropriate material, for example of stainless steel, the ohmic resistance of the inner wall is not negligible even if the inner wall is very thin. Therefore, the inner wall can directly be used as resistor for resistance heating of the inner wall even if the needle is manufactured in small dimensions.
    Type: Application
    Filed: May 16, 2007
    Publication date: November 29, 2007
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Frederic Ran