Patents by Inventor Frèdèric Subra

Frèdèric Subra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150232954
    Abstract: The invention relates to a method for quantifying linear forms of the DNA genome of the human immunodeficiency virus 1 (HIV-1) in a sample, wherein: a ligation reaction is performed with a double-stranded oligonucleotide suitable for ligation with the linear form of the HIV-1 DNA genome having a mature 3? end and/or the linear form of the HIV-1 DNA genome having a non-mature 3? end; a quantitative PCR is carried out from the ligation product obtained in the previous step; and the quantity of the linear form of the HIV-1 DNA genome having a mature 3? end and/or the quantity of the linear form of the HIV-1 DNA genome having a non-mature 3? end in the sample are deduced therefrom.
    Type: Application
    Filed: June 12, 2013
    Publication date: August 20, 2015
    Inventors: Soundasse Munir, Sylvain Thierry, Frédéric Subra, Eric Deprez, Olivier Delelis
  • Patent number: 8227433
    Abstract: The present invention relates to a method for treating proliferative mastocytosis comprising administering a Bruton tyrosine kinase (BTK) inhibitor, a BTK antisense to a mammal in need of such treatment. The invention is more particularly suited for treating category II, III and IV mastocytosis.
    Type: Grant
    Filed: May 3, 2004
    Date of Patent: July 24, 2012
    Assignees: Centre National de la Recherche Scientifique (CNRS), Paris-Sud, Universite, Ecole Normale Superieure de Cachan
    Inventors: Christian Auclair, Frédéric Subra
  • Publication number: 20100216733
    Abstract: The present invention relates to a method for treating proliferative mastocytosis comprising administering a Bruton tyrosine kinase (BTK) inhibitor, a BTK antisense to a mammal in need of such treatment. The invention is more particularly suited for treating category II, III and IV mastocytosis.
    Type: Application
    Filed: May 3, 2004
    Publication date: August 26, 2010
    Inventors: Christian Auclair, Frédéric Subra
  • Publication number: 20090286720
    Abstract: A pharmaceutical composition for the treatment, prevention or diagnosis of a tumoral pathology comprising an active agent which stabilizes an actin network of a cellular cytoskeleton.
    Type: Application
    Filed: April 20, 2009
    Publication date: November 19, 2009
    Applicants: Bioalliance Pharma, Ecole Normale Superieure de Cachan, Institut Gustave Roussy - IGR, Centre National de la Recherche Scientifique - CNRS
    Inventors: Christian Auclair, Valerie Amsellem, Martial Hervy, Frederic Subra
  • Patent number: 7491505
    Abstract: The invention concerns a method for analyzing tumor agressivity of cancer cells comprising measurement of the amount of stationary polymerized actin in a lysate of said cells. Advantageously, the measurement of the amount of stationary actin is carried out by fluorescence static polarization.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: February 17, 2009
    Assignees: Bioalliance Pharma, Ens Cachan, Centre National de la Recherche Scientifique-CNRS
    Inventors: Christelle Pragnon, Valérie Polard, Frédéric Subra, Christian Auclair
  • Publication number: 20060166289
    Abstract: The invention concerns a method for analyzing tumor agressivity of cancer cells comprising measurement of the amount of stationary polymerized actin in a lysate of said cells. Advantageously, the measurement of the amount of stationary actin is carried out by fluorescence static polarization.
    Type: Application
    Filed: December 18, 2003
    Publication date: July 27, 2006
    Inventors: Christelle Pragnon, Valerie Polard, Frederic Subra, Christian Auclair
  • Publication number: 20060148849
    Abstract: The invention relates to derivatives corresponding to formula I: in which X is an alkyl-(CH2)n— chain with n=0, 1 or 2, or O or N, Z is an aromatic which may contain heteroatoms chosen from O, N or S, as substitutions for the carbon atoms constituting said aromatic ring, this ring being substituted or otherwise with Rb, Rb represents 1 to 3 substituents chosen from —OH, —OR, —COOH, —COOR, —COH, —COR, —NH2, —NH(R), —NH(R,R?), —SH, —SR and CN, Ra is H or —(CH2)n?—Y, with n?=0, 1, 2 or 3 and Y and —CH3, —COOH, —COOR, —CN, —OH, —OR, SR, or an aryl group optionally substituted with Rb, R and R? represent a linear or branched alkyl chain of 1 to 4 C, and their pharmaceutically acceptable salts. Application as active ingredient of medicaments inhibiting retrovirus integrases.
    Type: Application
    Filed: March 1, 2006
    Publication date: July 6, 2006
    Inventors: Jean D'Angelo, Christophe Benard, Michele Danet, Marc Le Bret, Jean-Francois Mouscadet, Fatima Zouhiri, Marie Bayle, Didier Desmaele, Laurence Jeanson, Herve Leh, Frederic Subra
  • Patent number: 7064133
    Abstract: The invention relates to derivatives corresponding to formula I: in which X is an alkyl-(CH2)n— chain with n=0, 1 or 2, or O or N, Z is an aromatic which may contain heteroatoms chosen from O, N or S, as substitutions for the carbon atoms constituting said aromatic ring, this ring being substituted or otherwise with Rb, Rb represents 1 to 3 substituents chosen from —OH, —OR, —COOH, —COOR, —COH, —COR, —NH2, —NH(R), —NH(R,R?), —SH, —SR and CN, Ra is H or —(CH2)n?—Y, with n?=0, 1, 2 or 3 and Y and —CH3, —COOH, —COOR, —CN, —OH, —OR, SR, or an aryl group optionally substituted with Rb, R and R? represent a linear or branched alkyl chain of 1 to 4 C, and their pharmaceutically acceptable salts. Application as active ingredient of medicaments inhibiting retrovirus integrases.
    Type: Grant
    Filed: October 14, 2002
    Date of Patent: June 20, 2006
    Assignees: Bioalliance Pharma, Universite Paris SUD (Paris XI), Institut National de la Sante et de la Recherche Medicale (INSERM), Institut Gustave Roussy
    Inventors: Jean D'Angelo, Christophe Benard, Michele Danet, Marc Le Bret, Jean-Francois Mouscadet, Fatima Zouhiri, Marie Bayle, Didier Desmaele, Laurence Jeanson, Herve Leh, Frederic Subra
  • Publication number: 20040259911
    Abstract: The invention relates to derivatives corresponding to formula I: 1
    Type: Application
    Filed: August 18, 2004
    Publication date: December 23, 2004
    Inventors: Jean D'Angelo, Christophe Benard, Michele Danet, Marc Le Bret, Jean-Francois Mouscadet, Fatima Zouhiri, Marie Bayle, Didier Desmaele, Laurence Jeanson, Herve Leh, Frederic Subra
  • Publication number: 20040191230
    Abstract: A pharmaceutical composition for the treatment, prevention or diagnosis of a tumoral pathology comprising an active agent which stabilizes an actin network of a cellular cytoskeleton.
    Type: Application
    Filed: December 18, 2003
    Publication date: September 30, 2004
    Applicants: Bioalliance Pharma, a corporation of France, Ecole Normale Superieure de Cachan, a corporation of France, Institut Gustave Roussy - IGR, a corporation of France, Centre National de la Recherche Scientifique - CNRS, a corporation of France
    Inventors: Christian Auclair, Valerie Amsellem, Martial Hervy, Frederic Subra
  • Patent number: 6670377
    Abstract: The invention concerns quinoline derivatives of formula (I) in which: Ra, Rb and Rc, identical or different represent one or several substituents, themselves identical or different, in any position on the cycles, this or these substituents being selected among a —(CH2)n—Y or —CH═CH—Y group, in which Y is halogen, —OH, —OR, —COH, —COR, —COOH, COOR, —COH, —COR, —CONH2, —CON(Rx, Ry)—CH═NOH, —CO— —CH═NOH, —NH2, —N(Rx, Ry), —NO2, —PO(OR)2—SH2, —SR, —SO2R, —SO2NHR, CN, or Z(Rc) in which R is a C1-C8 alkyl, or aryl or a heterocyclic compound, Rx and Ry, identical or different are C1-C5 alkyl, an aryl or heterocyclic compound and n is nil or a whole number between 1 and 5 Rb can further represent a hydrogen, and when Y is —COOH or —COOR in Rc, Z, if it represents an aryl, comprises at least 3 substituents or the quinoline ring is trisubstitute
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: December 30, 2003
    Assignee: Centre National de la Recherche
    Inventors: Khalid Mekouar, Jean D'Angelo, Didier Desmaele, Jean-Francois Mouscadet, Frèdèric Subra, Christian Auclair