Abstract: The invention relates to compounds capable of inducing autophagy and metabolic reprogramming and to the use thereof as cardioprotectors, in particular in the context of anticancer therapy.

Abstract: The present invention is drawn to the use of Minaprine dihydrochloride and analogs thereof, for reducing tumor growth when administered to a patient suffering from cancer.

Abstract: The present invention is drawn to the use of the compounds highlighted in Tables 1 & 2 and analogs thereof, for enhancing IR-mediated cellular cannibalism in cancer cells. Said compounds are herein called “enhancers of IR-mediated cellular cannibalism”. They can be used to enhance tumor immunogenicity and/or to induce a significant protective anticancer immune response in subjects that will receive or that have received a radiotherapy treatment. In other words, said compounds can be used to potentiate a radiotherapy treatment in a subject in need thereof. Said compounds are preferably chosen in the group consisting of: Mebhydroline 1,5-napthalene disulfonate salt, Flurbiprofen, Minaprine dihydrochloride, Myricetin, Digoxin, Digitoxin, Lanatoside, LOPA87, VP331, RN-1-026, SG6163F, VP450, and VP43.

Abstract: A composition comprising at least one creatine fatty ester or salt thereof, at least one omega 3 fatty acid or salt thereof and at least one glyceride for use in medicine, the composition being free of non ionic surfactants and in particular said composition for use in treating the brain creatine transporter deficiency disease.

Abstract: A composition in the form of a micro-emulsion composed of an oil phase comprising at least one omega 3 fatty acid or salt thereof and at least one glyceride, an aqueous phase and one or more non ionic surfactant(s), said composition containing at least one creatine fatty ester or salt thereof. Further, a method for preparing such a composition and its use in medicine in particular for treating the brain creatine transporter deficiency disease.

Abstract: The present invention is drawn to the use of Minaprine dihydrochloride and analogs thereof, for reducing tumor growth when administered to a patient suffering from cancer.

Abstract: The present invention is drawn to the use of the compounds highlighted in Tables 1 & 2 and analogs thereof, for enhancing IR-mediated cellular cannibalism in cancer cells. Said compounds are herein called “enhancers of IR-mediated cellular cannibalism”. They can be used to enhance tumor immunogenicity and/or to induce a significant protective anticancer immune response in subjects that will receive or that have received a radiotherapy treatment. In other words, said compounds can be used to potentiate a radiotherapy treatment in a subject in need thereof. Said compounds are preferably chosen in the group consisting of: Mebhydroline 1,5-napthalene disulfonate salt, Flurbiprofen, Minaprine dihydrochloride, Myricetin, Digoxin, Digitoxin, Lanatoside, LOPA87, VP331, RN-1-026, SG6163F, VP450, and VP43.

Abstract: The present invention relates to the use of iminosydnone compounds in processes for the preparation of conjugates of two compounds of interest. The invention further relates to the use of said iminosydnone compounds in a process for releasing a compound of interest. The invention finally relates to novel iminosydnone compounds.

Abstract: The present invention concerns a method for preparing a creatine fatty ester or derivative thereof comprising at least one step consisting in reacting a diprotected creatinine with a molecule bearing at least one alcohol functional group and of formula R?—OH in which R? represents a hydrocarbon radical containing at least 4 carbon atoms. The present invention also concerns particular creatine fatty esters or derivative thereof and medical uses thereof.

Abstract: A method for preparing a pyrazole of formula (I) in which R,R? and R? have different meanings, characterised in that it involves reacting a sydnone of formula (II) in which R and R? have the meanings already indicated, with an alkyne of formula (III) in which R? has the meaning already indicated, in the presence of copper, to obtain a pyrazole compound of formula (I) that is then isolated and salified if desired.

Abstract: The present invention relates to the use of iminosydnone compounds in processes for the preparation of conjugates of two compounds of interest. The invention further relates to the use of said iminosydnone compounds in a process for releasing a compound of interest. The invention finally relates to novel iminosydnone compounds.

Abstract: The present invention relates to a process for the preparation of a first compound of interest C1 functionalized with a sydnone compound and to the corresponding functionalized C1 compound of interest. The present invention also relates to a process for the preparation of a conjugate of two compounds of interest C1 and C2 implying a sydnone compound and to the obtained conjugate. The present invention also relates to a process for preparing a compound of interest C2 comprising a strained alkyne moiety functionalized with a sydnone and to the corresponding functionalized compound of interest C2. It also relates to novel sydnone compounds substituted in position 4, which may be used in the above processes.

Abstract: A method for preparing a pyrazole of formula (I) in which R,R? and R? have different meanings, characterised in that it involves reacting a sydnone of formula (II) in which R and R? have the meanings already indicated, with an alkyne of formula (III) in which R? has the meaning already indicated, in the presence of copper, to obtain a pyrazole compound of formula (I) that is then isolated and salified if desired.

Abstract: The present invention concerns a method for preparing a creatine fatty ester or derivative thereof comprising at least one step consisting in reacting a diprotected creatinine with a molecule bearing at least one alcohol functional group and of formula R?—OH in which R? represents a hydrocarbon radical containing at least 4 carbon atoms. The present invention also concerns particular creatine fatty esters or derivative thereof and medical uses thereof.

Abstract: Azides of formula (I) in which V and W represent, independent of each other, a heterocycle comprising a copper-complexing nitrogen or sulphur heteroatom, said heterocycle being saturated or unsaturated, X and Y represent, independent of each other, a spacer moiety; Z represents a spacer moiety, F and F2 represent, independent of each other, a hydrogen atom or a functional moiety allowing the coupling of the azide of formula I with a chemical molecule, a biomolecule, a nanoparticle or a polymer, it being understood that at least one of F1 and F2 represents a functional moiety, methods of production and uses of same.

Abstract: The present invention relates to a method of radiolabelling carbon nanotubes, to the radiolabelled carbon nanotubes that can be obtained by implementing this method, and to applications thereof.

Abstract: The subject of the present invention is specific lactone compounds which can be used as antioxidant agents in pharmaceutical or cosmetic compositions or in food products, the said compounds containing a naphthalene ring onto which two lactone units are grafte.

Abstract: The present invention relates to a method of radiolabelling carbon nanotubes, to the radiolabelled carbon nanotubes that can be obtained by implementing this method, and to applications thereof.

Abstract: The present invention relates to a method of screening the operating conditions of a coupling reaction of at least two functional groups, and in particular of catalysts that are useful in this coupling reaction, and also to kits suitable for allowing this method to be carried out. Applications: fundamental and applied research, in particular in the areas of chemistry, agrofoods, pharmacy and environmental protection, for the development or optimization of synthesis reaction yields.