Abstract: The present invention relates to a combination of compounds for a use in therapy and especially to a therapeutic combination for use in the treatment of tumours and/or cancer. In particular, the invention relates to a therapeutic combination that comprises a NKCC1 protein inhibitor and a microtubule inhibitor, optionally together with one or more additional chemotherapeutic agents or radiotherapy. The combined administration includes at least one NKCC1 protein inhibitor and at least one microtubule inhibitor.

Abstract: The invention relates to a lateral flow device (10) for taking at least one analyte of interest in a fluid, comprising: a fluid receiving zone (100) for receiving the fluid, comprising a first absorbent material (111) that is capable of collecting the fluid; at least one zone of migration (201) for migration of the fluid, extending between a first end and a second end, each zone of migration including a draining material (211) in fluid continuity with the first absorbent material; at least one fluid reservoir (storage) zone (301) comprising a second absorbent material (311) in contact with the draining material at the level of the second end of each fluid migration zone; the detection means between the receiving zone and the reservoir zone, that provide the ability to determine the presence or absence of the said one or more analyte(s) of interest in the sample; characterised in that at least the one of the said zones of migration further also comprises at least one capture zone (400) that is capable of re

Abstract: The invention relates to a device (100) for sampling a biological tissue comprising: a rod (1) extending along a longitudinal axis (X) between a proximal end (1a) and a distal end (1b), a capture surface (2) borne by the rod (1), intended to be applied against a biological tissue, wherein the capture surface is nanoporous or has protrusions adapted for sampling a biological tissue by micro abrasion, an observation window (3) transparent to visible light, laid out in the external surface of the rod (1), a housing (4) extending in the rod, parallel to the longitudinal axis, from the proximal end (1a) as far as the observation window (3) said housing being able to receive a bundle of optical fibers.

Abstract: The invention relates to a device for in vivo sampling of biological species, comprising:—a capture medium made from a nanoporous material, having a capture surface for said species, said capture medium being supported by a plate,—a gripping rod,—an articulation comprising a first limb coupled to the gripping rod and a second limb coupled removably to the plate supporting the capture medium, such that the capture surface can be selectively oriented relative to the gripping rod, so as to adjust the orientation of the capture medium relative to the gripping rod.

Abstract: The invention relates to a lateral flow device (10) for taking at least one analyte of interest in a fluid, comprising: a fluid receiving zone (100) for receiving the fluid, comprising a first absorbent material (111) that is capable of collecting the fluid; at least one zone of migration (201) for migration of the fluid, extending between a first end and a second end, each zone of migration including a draining material (211) in fluid continuity with the first absorbent material; at least one fluid reservoir (storage) zone (301) comprising a second absorbent material (311) in contact with the draining material at the level of the second end of each fluid migration zone; the detection means between the receiving zone and the reservoir zone, that provide the ability to determine the presence or absence of the said one or more analyte(s) of interest in the sample; characterised in that at least the one of the said zones of migration further also comprises at least one capture zone (400) that is capable of re

Abstract: The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells.

Abstract: The invention relates to a device for in vivo sampling of biological species, comprising:—a capture medium made from a nanoporous material, having a capture surface for said species, said capture medium being supported by a plate,—a gripping rod,—an articulation comprising a first limb coupled to the gripping rod and a second limb coupled removably to the plate supporting the capture medium, such that the capture surface can be selectively oriented relative to the gripping rod, so as to adjust the orientation of the capture medium relative to the gripping rod.

Abstract: The present disclosure relates to a surgical instrument for sampling molecules in an organ which can be accessed directly or via a surgical portal, including: a device for capturing the molecules, a stylet supporting the capture device, capable of entering the organ, a guide for inserting the stylet into the body as far as the organ, wherein the distal end of the guide is provided with a damping block intended to come to bear upon the organ.

Abstract: The invention relates to an implantable energy source comprising at least one energy storage sub-system (171) constructed in the form of a stack of thin layers (175) on a substrate (176), characterised in that said energy storage sub-system has a plurality of through-openings (174) for allowing the development and the passage of blood vessels. Preferably, the energy source thereof has a thickness of less than, or equal to, 1 mm, over at least 80% of its surface.

Abstract: The invention relates to a device (100) for sampling a biological tissue comprising: a rod (1) extending along a longitudinal axis (X) between a proximal end (1a) and a distal end (1b), a capture surface (2) borne by the rod (1), intended to be applied against a biological tissue, wherein the capture surface is nanoporous or has protrusions adapted for sampling a biological tissue by micro abrasion, an observation window (3) transparent to visible light, laid out in the external surface of the rod (1), a housing (4) extending in the rod, parallel to the longitudinal axis, from the proximal end (1a) as far as the observation window (3) said housing being able to receive a bundle of optical fibers.

Abstract: The present invention relates to a sampling instrument adapted for taking a sample in situ and in vivo or taking a sample ex vivo of a target tissue or body structure, in a maximum quantity of less than 10?6 g, the instrument comprising an elongated active member (10) with a distal operative end (11) having at least one retaining surface (12) arranged for contacting directly the target tissue or body structure, capturing and retaining molecules of the target tissue or body structure thereto.

Abstract: Semiconductor wafer inspection device comprising a wager transport arm provided with at least one wafer support element, a wafer gripper, the gripper having two distant branches designed to take hold of the opposed edges of the wafer, the gripper being mounted so as to rotate on a shaft in order to be able to rotate the wafer between an approximately horizontal position and an approximately vertical position, and at least two inspection systems placed on one side of the wafer and on the other, in an approximately vertical position symmetrically with respect to the plane passing through the wafer.

Abstract: A method of sampling biological or biochemical species, comprising the following steps: a) arranging a capture surface (SC) for said biological or biochemical species in contact with a biological tissue or fluid (TB); and b) rinsing said surface to remove biological or biochemical species that have not been adsorbed; the method being characterised in that said capture surface is the surface of a nanoporous material (MC). A method of analysing said biological or biochemical species, characterised by the use of said surface as an analysis support. The analysis may in particular be performed using a method selected from mass spectroscopy with laser desorption and fluorescence imaging.

Abstract: An in vitro diagnostic method for diagnosing a brain tumour belonging to the group formed by two types of tumours: ODGs and GBMs, and for identifying the type of tumour, the method includes the measurement of at least two ratios of the expression levels of miRNA pairs extracted from a biological sample originating from a patient suspected of presenting one of the above-mentioned brain tumours.

Abstract: The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells.

Abstract: The present application relates to the use of miRNAs as biomarkers in glioma diagnosis. It also relates to the use of miRNAs as biomarkers in glioblastoma and oligodendroglioma diagnosis.

Abstract: The invention relates to the identification of genes involved in resistance of cancer cells to therapy, to short nucleic acid molecules which inhibit the expression of these genes by RNA interference and to their use as adjuvant in cancer therapy, to sensitize cancer cells to conventional anticancer agents; the short nucleic acid molecules are double-stranded short interfering nucleic acid molecules including a sense and an antisense region, wherein the sense region includes a nucleotide sequence that is selected from the group consisting of: the sequences SEQ ID NO: 15, 11, 13, 14, 30, 31, 38, 46, 64 and 70 and the sequences having at least 70% identity, preferably at least 80% identity, more preferably at least 90% identity with the sequences, and the antisense region includes a nucleotide sequence that is complementary to the sense region.

Abstract: The present disclosure relates to a surgical instrument for sampling molecules in an organ which can be accessed directly or via a surgical portal, including: a device for capturing the molecules, a stylet supporting the capture device, capable of entering the organ, a guide for inserting the stylet into the body as far as the organ, wherein the distal end of the guide is provided with a damping block intended to come to bear upon the organ.

Abstract: Semiconductor wafer inspection device comprising a wager transport arm provided with at least one wafer support element, a wafer gripper, the gripper having two distant branches designed to take hold of the opposed edges of the wafer, the gripper being mounted so as to rotate on a shaft in order to be able to rotate the wafer between an approximately horizontal position and an approximately vertical position, and at least two inspection systems placed on one side of the wafer and on the other, in an approximately vertical position symmetrically with respect to the plane passing through the wafer.

Abstract: The invention relates to the identification of genes involved in resistance of cancer cells to therapy, to short nucleic acid molecules which inhibit the expression of these genes by RNA interference and to their use as adjuvant in cancer therapy, to sensitize cancer cells to conventional anticancer agents; the short nucleic acid molecules are double-stranded short interfering nucleic acid molecules including a sense and an antisense region, wherein the sense region includes a nucleotide sequence that is selected from the group consisting of: the sequences SEQ ID NO: 15, 11, 13, 14, 30, 31, 38, 46, 64 and 70 and the sequences having at least 70% identity, preferably at least 80% identity, more preferably at least 90% identity with the sequences, and the antisense region includes a nucleotide sequence that is complementary to the sense region.