Patents by Inventor François Clemence

François Clemence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8084428
    Abstract: A method of repairing a meniscal tear of a subject includes providing a sheet of collagen membrane material having on one side thereof a smooth barrier face which inhibits cell adhesion thereon and inhibits passage of cells therethrough. The sheet has a fibrous face opposite the smooth barrier face, the fibrous face allowing cell growth thereon. The collagen is predominantly collagen I. The sheet of collagen membrane material is fixed over a meniscal tear so that the fibrous face is oriented toward the meniscal tear.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: December 27, 2011
    Assignee: Ed. Geistlich Soehne AG fuer Chemische Industrie
    Inventors: Myron Spector, Peter Geistlich, Lothar Schloesser, Roland Jakob, Jean-Francois Clemence
  • Publication number: 20090186062
    Abstract: A method of repairing a meniscal tear of a subject includes providing a sheet of collagen membrane material having on one side thereof a smooth barrier face which inhibits cell adhesion thereon and inhibits passage of cells therethrough. The sheet has a fibrous face opposite the smooth barrier face, the fibrous face allowing cell growth thereon. The collagen is predominantly collagen I. The sheet of collagen membrane material is fixed over a meniscal tear so that the fibrous face is oriented toward the meniscal tear.
    Type: Application
    Filed: September 1, 2006
    Publication date: July 23, 2009
    Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIE
    Inventors: Myron Spector, Peter Geistlich, Lothar Schloesser, Roland Jakob, Jean-Francois Clemence
  • Patent number: 6534515
    Abstract: A compound selected from the group consisting of all possible isomers or racemates of a compound of the formula wherein the various substituents are as defined in the specification and its non-toxic, pharmaceutically acceptable salts with acids or bases having anti-anoxic, anti-ischemic and neuronal protective anti-depressant activities.
    Type: Grant
    Filed: April 15, 1994
    Date of Patent: March 18, 2003
    Assignee: Aventis Pharma S.A.
    Inventors: François Clemence, Jean-Luc Haesslein, Claude Oberlander
  • Publication number: 20020045637
    Abstract: A compound selected from the group consisting of all possible isomers or racemates of a compound of the formula 1
    Type: Application
    Filed: April 15, 1994
    Publication date: April 18, 2002
    Inventors: FRANCOIS CLEMENCE, JEAN-LUC HAESSLEIN, CLAUDE OBERLANDER
  • Patent number: 6271395
    Abstract: A compound selected from the group consisting of enantiomers and diastereoisomer forms and mixtures thereof of the formula wherein the substituents are defined as in the application having a strong affinity for optical receptors, central analgesic, diuretic, anti-arrythmic, hypotensive and cerebral anti-ischemic activity.
    Type: Grant
    Filed: December 15, 1994
    Date of Patent: August 7, 2001
    Assignee: Hoechst Marion Roussol
    Inventors: François Clemence, Odile Le Martret, Françoise Delevallee, Michel Fortin
  • Patent number: 6080412
    Abstract: A method of producing a microencapsulated pharmaceutical formulation is disclosed comprising causing a dye to be attached to the surface of pharmaceutical particles or particle clusters and applying a source of radiant energy to the dye in the presence of a liquid polymeric or polymerisable material so as to cause the material to cross-link, producing a conformal layer of cross-linked polymer on the particulate surfaces. Preferably, the polymer provides an immuno-protective layer around the particles, while allowing therapeutic components to exit the microcapsules. Microencapsulated pharmaceutical formulations and their medical use are also disclosed, especially for the treatment of diabetes by encapsulating insulin secreting cells.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: June 27, 2000
    Assignee: Ecole Polytechnic Federale de Lausanne et al.
    Inventors: Olivier Jordan, Patrick Aebischer, Jean-Francois Clemence
  • Patent number: 6004979
    Abstract: Compounds of the formula ##STR1## in all possible racemic, enantiomeric and diastereoisomeric forms and their non-toxic, pharmaceutically acceptable salts with acids and bases having antagonistic properties for angiotensin II receptors and a process and novel intermediates for their properties.
    Type: Grant
    Filed: May 1, 1998
    Date of Patent: December 21, 1999
    Assignee: Hoechst Marion Roussel
    Inventors: Francois Clemence, Michel Fortin, Jean-Luc Haesslein
  • Patent number: 5817674
    Abstract: Compounds of the formula ##STR1## in all possible racemic, enantiomeric and diastereoisomeric forms and their non-toxic, pharmaceutically acceptable salts with acids and bases having antagonistic properties for angiotensin II receptors and a process and novel intermediates for their properties.
    Type: Grant
    Filed: January 5, 1996
    Date of Patent: October 6, 1998
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Michel Fortin, Jean-Luc Haesslein
  • Patent number: 5478938
    Abstract: Novel bicyclic compounds in all possible racemic, enantiomeric and diasteroisomeric forms of the formula ##STR1## having antagonistic properties for angiotensin II receptors and novel intermediates and process for their preparation.
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: December 26, 1995
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Michel Fortin, Jean-Luc Haesslein
  • Patent number: 5436244
    Abstract: Novel indanes in all possible stereoisomer forms of the formula ##STR1## wherein the substituents are as defined in the specification and their non-toxic, pharmaceutically acceptable acid addition salts and their hydrates having central analgesic properties as well as antiarrhythmic and diuretic activities.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: July 25, 1995
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Michel Fortin, Gilles Hamon, Odile Le Martret, Anne M. Moura
  • Patent number: 5424314
    Abstract: A compound in all racemic or optionally active forms selected from the group consisting of a compound of the formula ##STR1## where the substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable acid addition salts having anti-anoxic activity and a novel process and intermediates for their preparation.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: June 13, 1995
    Assignee: Roussel-Uclaf
    Inventors: Francois Clemence, Jean-Luc Haesslein, Claude Oberlander
  • Patent number: 5395843
    Abstract: A compound selected from the group consisting of all possible racemic, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein E and G together form a group selected from the group: ##STR2## wherein A, R, R.sub.1, R.sub.2 and Y are as defined in the specification.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: March 7, 1995
    Assignee: Roussel-Uclaf
    Inventors: Francois Clemence, Michel Fortin, Odile Le Martret
  • Patent number: 5380722
    Abstract: Novel indole-carboxamides of the formula ##STR1## and their non-toxic pharmaceutically acceptable acid addition salts having remarkable anti-arrhytmic properties.
    Type: Grant
    Filed: May 25, 1993
    Date of Patent: January 10, 1995
    Assignee: Roussel-Uclaf
    Inventors: Francois Clemence, Jacques Guillaume, Gilles Hamon
  • Patent number: 5356907
    Abstract: A compound selected from the group consisting of all possible racemic, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein E and G together form a group selected from the group: ##STR2## consisting of a) ##STR3## wherein, A is a cycloalkyl of 3-6 carbon optionally substituted, R, R.sub.1, R.sub.2 and Y are defined in the specification.
    Type: Grant
    Filed: October 1, 1992
    Date of Patent: October 18, 1994
    Assignee: Roussel UCLAF
    Inventors: Francois Clemence, Michel Fortin, Odile Le Martret
  • Patent number: 5348971
    Abstract: Novel indanes in all possible stereoisomer forms of the formula ##STR1## wherein the substrates are as defined in the application and their non-toxic, pharmaceutically acceptable acid addition salts and their hydrates are disclosed as having central analgesic properties as well as antiarrhythmic and diuretic activities.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: September 20, 1994
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Michel Fortin, Gilles Hamon, Odile Le Martret, Anne-Marie Moura
  • Patent number: 5332748
    Abstract: A compound and all possible racemic or optically active isomer forms, selected from the group consisting of compound of the formula ##STR1## wherein the substituents are defined as set forth in the application as filed. Useful for treating cerebral insufficiencies of anoxic or ischemic origin.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: July 26, 1994
    Assignee: Roussel-Uclaf
    Inventors: Nurgun Aktogu, Francois Clemence, Claude Oberlander
  • Patent number: 5324839
    Abstract: Novel bicyclic compounds in all possible racemic, enantiomeric and diasteroisomeric forms of the formula ##STR1## having antagonistic properties for angiotensin II receptors and novel intermediates and process for their preparation.
    Type: Grant
    Filed: February 6, 1992
    Date of Patent: June 28, 1994
    Assignee: Roussel-Uclaf
    Inventors: Francois Clemence, Michel Fortin, Jean-Luc Haesslein
  • Patent number: 5278180
    Abstract: A novel process for the preparation of 4H-1,2,4-triazoles in their racemic or optically active forms of the formula ##STR1## wherein the compounds have analgesic activity.
    Type: Grant
    Filed: May 4, 1992
    Date of Patent: January 11, 1994
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Claudine Maushart, Philippe Mackiewicz, Francoise Delevallee
  • Patent number: 5254566
    Abstract: A compound selected from the group consisting of racemates, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms optionally substituted with at least one halogen, hydroxy, alkyl or alkoxy of 1 to 4 carbon atoms or taken together with the nitrogen to which they are attached form a heterocycle optionally containing a heteroatom selected from the group consisting of --O--, --S-- and nitrogen optionally substituted with alkyl or alkoxy of 1 to 5 carbon atoms, optionally substituted benzyl and phenyl, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, halogen, hydroxy and alkyl and alkoxy of 1 to 5 carbon atoms optionally substituted with at least one substituent selected from the group consisting of halogen, hydroxy, phenyl and alkyl and alkoxy of 1 to 4 carbon atoms, R.sub.
    Type: Grant
    Filed: September 22, 1992
    Date of Patent: October 19, 1993
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Gilles Hamon, Odile Le Martret
  • Patent number: 5234944
    Abstract: A compound selected from the group consisting of enantiomers and diastereoisomer forms and mixtures thereof of the formula ##STR1## wherein R.sub.6 is selected from the group consisting of hydrogen, halogen and alkyl and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually hydrogen or alkyl of 1 to 5 carbon atoms or taken together with the carbon atoms to which they are attached form a cycloalkyl of 3 to 6 carbon atoms optionally containing a heteroatom selected from the group consisting of --S--, --O-- and --N--, one of A and B has the formula ##STR2## and the other has the formula ##STR3## R is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, Z is selected from the group consisting of --(CH.sub.2).sub.n --, branched alkylene of 2 to 8 carbon atoms and --CH.sub.2 O--, n is an integer of 0 to 5, X, X' and X" are individually selected from the group consisting of hydrogen, alkyl and alkoxy of 1 to 4 carbon atoms, halogen, --OH, --CF.sub.3, --NO.sub.2, --NH.sub.
    Type: Grant
    Filed: November 3, 1992
    Date of Patent: August 10, 1993
    Assignee: Roussel UCLAF
    Inventors: Francois Clemence, Odile Le Martret, Francoise Delevallee, Michel Fortin