Patents by Inventor François CLEMENT
François CLEMENT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230117652Abstract: The invention relates to a method for detecting a mutation in a microsatellite sequence locus of a target fragment from a DNA sample, comprising subjecting said DNA sample to a digital polymerase chain reaction (PCR) in the presence of a PCR solution comprising: a pair of primers for amplifying said target fragment of the DNA sample including said microsatellite sequence; a first MS oligonucleotide (MS) hydrolysis probe, labeled with a first fluorophore, wherein said first MS oligonucleotide probe is complementary to a wild-type sequence including the microsatellite sequence; and a second oligonucleotide reference (REF) hydrolysis probe, labeled with a second fluorophore, wherein said second oligonucleotide REF probe is complementary to a wild-type sequence of said target DNA fragment which does not include said microsatellite sequence. The invention also encompasses methods for the diagnosis and prognosis of cancer and a method for determining the efficacy of a cancer treatment.Type: ApplicationFiled: September 21, 2022Publication date: April 20, 2023Applicants: Institut Curie, Institut National de la Sante et de la Recherche Medicale, Universite de Versailles Saint-Quentin-en-YvelinesInventors: Charlotte Proudhon, Amélie Kasperek, Amanda Bortolini Silveira, François-Clément Bidard, Marc-Henri Stern
-
Publication number: 20220099292Abstract: Disclosed is a portable hot air generator apparatus which includes a handle and a body forming a Venturi and, furthermore, a damping system between the handle and the body.Type: ApplicationFiled: September 30, 2021Publication date: March 31, 2022Inventor: François CLEMENT
-
Publication number: 20210024984Abstract: The present invention relates to an in vitro method for identifying and/or characterizing one or more mutations in a hotspot mutation sequence of at least one ESR1 target fragment from a DNA sample, said method comprising subjecting the DNA sample to a drop-off digital polymerase chain reaction (PCR) in the presence of a PCR solution comprising: a pair of primers suitable for amplifying an ESR1 target fragment; an oligonucleotide reference (REF) hydrolysis probe, labeled with a fluorophore, wherein said REF oligonucleotide probe is complementary to a wild-type sequence of the target fragment located outside of the hotspot mutation sequence; an oligonucleotide hotspot (HOTSPOT) hydrolysis probe, labeled with another fluorophore, wherein said oligonucleotide HOTSPOT probe is complementary to a wild-type sequence of the hotspot mutation sequence of the target DNA fragment.Type: ApplicationFiled: March 14, 2019Publication date: January 28, 2021Applicants: Universite de Versailles Saint-Quentin-en-Yvelines, Universite de Paris, Institut National de la Santé et de la Recherche Médicale, Institut CurieInventors: Marc-Henri Stern, Emmanuelle Jeannot, Charlotte Proudhon, Jean-Yves Pierga, François-Clément Bidard
-
Publication number: 20200291466Abstract: The invention relates to a method for detecting a mutation in a microsatellite sequence locus of a target fragment from a DNA sample, comprising subjecting said DNA sample to a digital polymerase chain reaction (PCR) in the presence of a PCR solution comprising: a pair of primers for amplifying said target fragment of the DNA sample including said microsatellite sequence; a first MS oligonucleotide (MS) hydrolysis probe, labeled with a first fluorophore, wherein said first MS oligonucleotide probe is complementary to a wild-type sequence including the microsatellite sequence; a second oligonucleotide reference (REF) hydrolysis probe, labeled with a second fluorophore, wherein said second oligonucleotide REF probe is complementary to a wild-type sequence of said target DNA fragment which does not include said microsatellite sequence. The invention also encompasses methods for the diagnosis and prognosis of cancer and a method for determining the efficacy of a cancer treatment.Type: ApplicationFiled: July 11, 2018Publication date: September 17, 2020Applicants: Institut Curie, Institut National de la Santé et de la Recherche Médicale, Universite de Versailles Saint-Quentin-en-YvelinesInventors: Charlotte PROUDHON, Amélie KASPEREK, Amanda BORTOLINI SILVEIRA, François-Clément BIDARD, Marc-Henri STERN
-
Patent number: 9482430Abstract: A heat-shrink gun in which an ignition voltage of the gaseous mixture is generated by a piezoelectric lighter (12), under the action of a trigger (8) when it is moved from a waiting position (8A) to a lighting position, characterized in that the trigger can also assume a loading position (8B), in which it free access (DC) to a working housing for the lighter.Type: GrantFiled: March 21, 2012Date of Patent: November 1, 2016Assignee: SEFMATInventor: François Clement
-
Patent number: 8529248Abstract: The invention relates to an apparatus comprising an injection device (1) for producing a flow of a high-speed combustible gas mixture, and a burner head (2) in which said flow is injected through a tabular extender (70) connecting said injection device (1) to said head (2). The extender has a maximal length higher than 600 mm and includes at the gravity center of the device assembly, means for suspension to a portion of the operator's body.Type: GrantFiled: October 30, 2007Date of Patent: September 10, 2013Assignee: SefmatInventor: Francois Clement
-
Publication number: 20120288809Abstract: A hot air generating device of the type including an injection device (2) capable of producing a flow of a combustible gas mixture at a high speed and a burner head (3) in which the flow is ignited via a spark plug (6) positioned near the burner (3) and electrically connected to a lighter (12), preferably a piezoelectric lighter, including an autotransformer mounted in parallel between the lighter and the spark plug. Such a device is particularly advantageous to facilitate the lighting of the mixture, in particular when the device is provided with a riser between the lighter and the spark plug.Type: ApplicationFiled: March 21, 2012Publication date: November 15, 2012Applicant: SEFMATInventor: Francois CLEMENT
-
Publication number: 20120288808Abstract: A heat-shrink gun in which an ignition voltage of the gaseous mixture is generated by a piezoelectric lighter (12), under the action of a trigger (8) when it is moved from a waiting position (8A) to a lighting position, characterized in that the trigger can also assume a loading position (8B), in which it free access (DC) to a working housing for the lighter.Type: ApplicationFiled: March 21, 2012Publication date: November 15, 2012Applicant: SEFMATInventor: François CLEMENT
-
Patent number: 8306803Abstract: The invention concerns a method for verifying, prior to fabrication, the proper operation of integrated circuit electronic systems using analog signals. It comprises the following steps: identifying (22) the noise-sensitive circuits, setting an acceptable sensitivity template for these noise-sensitive circuits, identifying (34) the noise-generating circuits, modeling the noise, determining (50) the function for transferring noise to the sensitive circuits, and comparing (58) the level of noise reaching the sensitive circuits to an acceptable sensitivity threshold template for the sensitive circuits.Type: GrantFiled: July 28, 2006Date of Patent: November 6, 2012Assignee: Coupling Wave Solutions CWSInventor: Francois Clement
-
Publication number: 20110029298Abstract: Method for modelling the noise injected into an electronic system. The invention relates to a method of modelling the noise injected into a mixed system (1) of digital and analogue, and/or radio-frequency type. In the invention, the injection of noise in the system (1) is modelled by macro-models of digital cells (8, 8.1-8.N) which model, in particular, noise related to the switching of the digital cells (C1-CN), and by models of lines (L1-LN) modelling, in particular, the noise resulting from a change of state of the signals transported over the lines.Type: ApplicationFiled: June 26, 2007Publication date: February 3, 2011Inventors: Francois Clement, Amine Dhia, Benoit Emmanuel Fabin
-
Publication number: 20100075266Abstract: The invention relates to an apparatus comprising an injection device (1) for producing a flow of a high-speed combustible gas mixture, and a burner head (2) in which said flow is injected through a tabular extender (70) connecting said injection device (1) to said head (2). The extender has a maximal length higher than 600 mm and includes at the gravity centre of the device assembly, means for suspension to a portion of the operator's body.Type: ApplicationFiled: October 30, 2007Publication date: March 25, 2010Applicant: SEFMATInventor: Francois Clement
-
Publication number: 20100017173Abstract: The present invention is a method for modeling the switching activity of a digital circuit, this digital circuit comprising cells linked together by interconnections, these cells switching at an instant at which at least one of their inputs changes state, successive switchings of the cells of the circuits occurring during a clock period Tclk of this circuit, the clock period includes the following steps: calculating based on an adapted statistical model the number of cells liable to switch over each time interval [tk, tk+1] of the clock period, and allocating switching instants to the different cells of the digital circuit based on the knowledge of the number of cells liable to switch over the time intervals [tk; tk+1]. The present invention is further a production method.Type: ApplicationFiled: July 12, 2007Publication date: January 21, 2010Applicant: COUPLING WAVE SOLUTIONS CWSInventors: Benoit Emmanuel Fabin, Francois Clement
-
Publication number: 20090234630Abstract: The invention concerns a method for verifying, prior to fabrication, the proper operation of integrated circuit electronic systems using analog signals. It comprises the following steps: identifying (22) the noise-sensitive circuits, setting an acceptable sensitivity template for these noise-sensitive circuits, identifying (34) the noise-generating circuits, modeling the noise, determining (50) the function for transferring noise to the sensitive circuits, and comparing (58) the level of noise reaching the sensitive circuits to an acceptable sensitivity threshold template for the sensitive circuits.Type: ApplicationFiled: July 28, 2006Publication date: September 17, 2009Inventor: Francois Clement
-
Publication number: 20050100442Abstract: Titanium-based metal parts (1, 3) are soldered by using as a filler metal (7) an aluminium alloy containing magnesium and virtually no silicon. Application to the bonding of blades (3) to the inner shroud (1) of an aeronautical gas turbine engine compressor nozzle ring.Type: ApplicationFiled: September 29, 2004Publication date: May 12, 2005Applicant: SNECMA MOTEURSInventor: Jean-Francois Clement
-
Publication number: 20040241845Abstract: The present invention relates to mammalian Staufen, a double-stranded RNA-binding protein involved in mRNA transport and localization. The invention further relates to the demonstration of the association of a RNA-binding protein with the rough endoplasmic reticulum (RER), implicating Staufen and related proteins in the transport of RNA to its site of translation. Broadly, the invention therefore relates to transport and translation of RNA. More specifically, the present invention relates to human and mouse Staufen proteins and to the modulation of transport of RNA to the RER by these proteins. The present invention also relates to isolated nucleic acid molecules encoding mammalian Staufen, as well as vectors and host cells harboring same. In addition, the present invention relates to screening assays for identifying modulators of Staufen activity and to the identification of mutants thereof which abrogate their interaction with RER.Type: ApplicationFiled: April 8, 2004Publication date: December 2, 2004Inventors: Luc Desgroseillers, Andrew Mouland, Laurent Chatel-Chaix, Jean-Francois Clement
-
Patent number: 6291720Abstract: This application relates to a process for making glycol ethers, said process comprising reacting an olefin oxide with an alcohol over a catalyst comprising a crystalline metallosilicate which is basic in character, wherein the molar ratio of alcohol to olefin oxide employed is at least 2:1.Type: GrantFiled: April 26, 1999Date of Patent: September 18, 2001Assignee: BP Chemicals LimitedInventors: Warren John Smith, Francois Clement Malherbe
-
Patent number: D809237Type: GrantFiled: October 25, 2016Date of Patent: January 30, 2018Assignee: SEFMATInventor: Francois Clement
-
Patent number: D972384Type: GrantFiled: March 25, 2021Date of Patent: December 13, 2022Assignee: SEFMATInventor: François Clement
-
Patent number: D972385Type: GrantFiled: March 25, 2021Date of Patent: December 13, 2022Assignee: SEFMATInventor: François Clement