Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: An exterior ferrule of an intermediate housing for an aircraft turbine engine, the ferrule made of composite material comprising a downstream annular linking end forming a peripheral groove and intended to receive a complementary linking member provided on one or more nacelle cowls, the ferrule being made from: a first fibrous preform obtained by three-dimensional weaving of yarns and densified by a matrix, the preform defining a drum of the ferrule as well as a structural part of the downstream groove wall; and a second fibrous preform obtained by three-dimensional weaving of yarns and densified by a matrix, the preform defining a base abutting the exterior of the drum defined by the first preform, as well as a structural part of the upstream groove wall.

Abstract: A turbomachine blade is made of composite material formed of woven fibers and embedded in a polymerised resin. The blade includes a root connected by a stilt to a vane which comprises a pressure side and a suction side. At least one anti-wear strip of fabric is located on a surface of the root and/or the stilt. At least one anti-wear strip is secured to the root surface in a unitary manner by the resin.

Abstract: A system and method is provided for generating a tone mapping function to reduce dynamic range of a first image to produce a second image. A luma signal and a plurality of chroma components are determined and a gamut color correction is then performed. An adaptive function is generated by comparing the luma signal and at least one chroma component of the first and second image.

Abstract: Devices for distributing oil to a rolling bearing for an aircraft turbine engine include a rolling bearing including two rings, respectively an inner ring and an outer ring, an oil distribution ring configured to be mounted on a turbine engine shaft, said distribution ring including a first outer cylindrical surface for mounting the inner ring of the bearing, an oil recovery scoop supplying a lubricating circuit of the bearing, and an annular track of a dynamic seal. The distribution ring and the track are formed by a single-piece body, and the lubricating circuit is formed in said body and extends into the distribution ring and the track.

Abstract: A catalytic system based on at least one rare-earth metallocene and an organomagnesium reagent as co-catalyst of formula RB—(Mg—RA)m—Mg—RB is provided. According to the formula, RB comprises a benzene nucleus substituted with the magnesium atom. One of the carbon atoms of the benzene nucleus ortho to the magnesium is substituted with a methyl, an ethyl or an isopropyl or forms a ring with the carbon atom which is its closest neighbour and which is meta to the magnesium. The other carbon atom of the benzene nucleus ortho to the magnesium is substituted with a methyl, an ethyl or an isopropyl. RA is a divalent aliphatic hydrocarbon-based chain, optionally interrupted with one or more oxygen or sulfur atoms or with one or more arylene groups. The m is a number greater than or equal to 1, preferably 1. The catalytic system allows the synthesis of dienic and/or ethylenic telechelic polymers.

Abstract: A rubber composition contains: an elastomer matrix comprising at least one diene elastomer comprising epoxide functions, at least one reinforcing filler, and a system for crosslinking said polymer, comprising at least one organopolyphosphorus compound of general formula (I) in which A represents a covalent bond or a hydrocarbon group comprising at least 1 carbon atom, which is optionally substituted and which optionally comprises one or more heteroatoms, and the Rs represent, independently of one another, a hydrocarbon group comprising at least 1 carbon atom or a hydrogen atom.

Abstract: A triblock polymer of formula B-A-B is provided. According to the formula, the symbol A represents a “central” block which is a statistical copolymer comprising units of a 1,3-diene and more than 50 mol % of ethylene units. The symbols B each represent an “end” block which is a polyethylene with a melting point of greater than 90° C. and a number-average molar mass of greater than or equal to 2000 g/mol and less than or equal to 10 000 g/mol. The polymer has improved rheological properties relative to a statistical copolymer based on ethylene and 1,3-diene of the same microstructure without changing its mechanical and dynamic or thermal properties.

Abstract: A process for preparing a multiblock polymer by statistical copolymerization of a mixture containing ethylene and a 1,3-diene and subsequent polymerization of ethylene in the presence of a rare-earth metallocene and an organomagnesium reagent RB—(Mg—RA)m—Mg—RB or X—Mg—RA—Mg—X is provided. According to the formula, RA is a divalent aliphatic hydrocarbon-based chain optionally interrupted with one or more oxygen or sulfur atoms or arylene groups, RB comprises a benzene nucleus substituted with the Mg atom, one of the carbon atoms of the benzene nucleus ortho to the Mg is substituted with a methyl, an ethyl or an isopropyl or forms a ring with the carbon atom which is its closest neighbour and which is meta to the Mg. The other carbon atom of the benzene nucleus ortho to the Mg is substituted with a methyl, ethyl or isopropyl, X being a halogen atom, m being greater than or equal to 1.

Abstract: A turbofan engine has a primary duct, in which there flows a primary flow at a primary pressure and a secondary duct, which radially surrounds the primary duct and in which there flows a secondary flow at a secondary pressure. The primary duct includes at least one compressor configured to compress the primary flow, a turbine driving the compressor in rotation and a combustion chamber designed to receive, at an inlet, the primary air flow compressed by the compressor. The turbomachine further includes a cooling circuit extending between the compressor and the turbine. The cooling circuit has an air flow rate regulating device arranged upstream of the turbine and having at least one valve that is configured to move between an open position and a closed position, located between the compressor and the combustion chamber in the primary duct and the pressure (PS) in the secondary duct.

Abstract: A telechelic polymer of formula Z1-POLY-Z2 is provided. The term “POLY” denotes a polymer chain comprising units of a 1,3-diene, ethylene units and cyclic units, 1,2-cyclohexane units, Z1 and Z2 denoting a group containing a function, Z1 and Z2 being identical. The polymer has a macrostructure defined by a dispersity of less than 1.5 or by a number-average molar mass of greater than 10 000 g/mol.

Abstract: A catalytic system based on at least one rare-earth metallocene and as co-catalyst an organomagnesium reagent of formula X—Mg—RA—Mg—X is provided. In the formula, RA is a divalent aliphatic hydrocarbon-based chain, optionally interrupted with an oxygen atom, a sulfur atom or with an arylene group, and X is a halogen atom. The catalytic system allows the synthesis of dienic and/or ethylenic telechelic polymers.

Abstract: A method is provided that is performed by a smart network interface card (SmartNIC) that is in communication with a host device that serves as a forwarder in an Hybrid Information-Centric Network (hICN). The method includes storing in a memory of the SmartNIC, mapping information that maps a subset of names of content contained in a content store that is stored in a memory of the host device to corresponding addresses of the content. The method further includes receiving at the SmartNIC, from a requester, an interest that includes a name, and determining whether the name of the interest is included in the mapping information stored in the SmartNIC. The method includes processing the interest based on whether the name of the interest is contained in the mapping information stored in the memory of the SmartNIC.

Abstract: A turbomachine assembly includes a casing, first and second rotors, and a damper. The first rotor includes a disk and blades and is movable in rotation relative to the casing. The second rotor is movable relative to the casing around a longitudinal axis. The damper damps a movement of the first rotor relative to the second rotor. The damper includes first to third parts. The first part bears on the first rotor in a first area extending over a first angular sector around the longitudinal axis and applies a first centrifugal force on the first rotor. The second part bears on the first rotor in a second area that is smaller than the first angular sector and extends over a second angular sector around the longitudinal axis. The third part bears on the second rotor and applies a second centrifugal force on the second rotor.

Abstract: Presented herein are a combination of techniques that will ensure that the traffic is sent to the proxy right from the first packet without any delay using transient transport, and upgraded to Hybrid Information-Centric Networking (hICN) immediately upon completion of the stack initialization and we have full connectivity. More specifically, a mechanism is provided to dynamically establish hICN connections to transport latency-sensitive traffic, due to a transient User Datagram Protocol (UDP) fallback. This allows a reliable conversion between the push-based IP model, and the pull-based hICN model with no connectivity interruption. This is useful to implement proxy functionalities exposing regular IP applications to hICN to leverage its benefits in terms of performance or seamless mobility.

Abstract: A catalytic system based on at least one metallocene and on a diorganomagnesium compound of formula RB—Mg—RA is provided, RB being different from RA and comprising a benzene nucleus substituted with a magnesium atom, one of the carbon atoms of the benzene nucleus ortho to the magnesium being substituted with a methyl, an ethyl, an isopropyl or forming a ring with the carbon atom which is its closest neighbour and which is meta to the magnesium, the other carbon atom of the benzene nucleus ortho to the magnesium being substituted with a methyl, an ethyl or an isopropyl, RA being an alkyl, a cycloalkyl or a benzyl, which may be substituted or unsubstituted. The catalytic system makes it possible to increase the functional group content in the synthesis of a functional polymer.

Abstract: The present invention relates to a turbomachine assembly, comprising: a casing (10), a first rotor (12) which is movable in rotation with respect to the casing (10) about a longitudinal axis (X-X), and comprising: *a disk (120), and *a plurality of blades (122) capable of flapping with respect to the disk (120) during a rotation of the first rotor (12) with respect to the casing (10), a second rotor (140) which is movable in rotation with respect to the casing (10) about the longitudinal axis (X-X), and a damper (2) which is configured to damp a displacement of the first rotor (12) with respect to the second rotor (140) in a plane orthogonal to the longitudinal axis (X-X), the displacement being caused by a flapping of at least one blade (122) among the plurality of blades (122), the damper (2) comprising: o a first bearing part (21): *bearing against the first rotor (12), and *being configured to apply a first centrifugal force (C1) to the first rotor (12), o a second bearing part (22): *bearing against the

Abstract: The present invention relates to an assembly for a turbomachine, comprising: a first rotor; a second rotor, and a damper (2) configured to damp a displacement of the first rotor relative to the second rotor, the damper comprising: a first portion (21) bearing against the first rotor and having a first thickness, a second portion (22) bearing against the second rotor and having a second radial thickness, and a third portion (23) connecting the first portion (21) to the second portion (22) and having a third radial thickness, wherein the third radial thickness is greater than at least one of the first radial thickness and the second radial thickness.

Abstract: Method and System for providing a medical drug recommendation. Time and location data is read from received client data. Weather data is retrieved based on the time and location data and the weather data is stored in a user data set. A medical drug recommendation is computed from a user data set that comprises migraine event data by using a statistical model. Furthermore, a server is prepared to provide medical drug recommendations, wherein a statistical model for delivering a medical drug recommendation is adjusted by providing user data as input data to a statistical model, the user data sets comprising migraine events.

Abstract: Device for distributing oil from a rolling bearing (8) for an aircraft turbine engine, comprising: —a rolling bearing (8), —a body (5) for distributing oil, which body is configured to be mounted on a turbine engine shaft (4), said body comprising: i) a first outer cylindrical surface (5a) for mounting the inner ring (12) of the bearing, ii) a ring-shaped scoop (11) for recovering oil, iii) a ring-shaped track (26) of a dynamic seal (22), iv) a circuit (7) for lubricating the bearing and cooling the track, said circuit being formed in the body, characterised in that the ring-shaped scoop is the first scoop (11a) which supplies a first portion (7x) of the circuit with a view to cooling the track, and in that the body comprises a second ring-shaped scoop (11b) for recovering oil, which scoop supplies a second portion (7y) of the circuit with a view to lubricating the bearing.